Navigation Links
Champions Biotechnology Begins Preclinical Development of Its Lead Oncology Drug Candidate
Date:6/17/2008

ARLINGTON, Va., June 17 /PRNewswire-FirstCall/ -- Champions Biotechnology, Inc. (OTC Bulletin Board: CSBR), a company engaged in the development of advanced preclinical platforms and tumor specific data to enhance the value of oncology drugs, today announced that it has begun preclinical development of the lead Benzoylphenylurea (BPU) sulfur analog compound that the Company acquired last year. The compound has shown promising activity against in vitro and in vivo models of prostate and pancreatic cancer.

Preclinical supplies of the drug substance have been recently secured and the preclinical development process is being initiated. Champions Biotechnology intends to test the BPU Agent utilizing its Biomerk Tumorgraft(TM) Preclinical Platform. Studies utilizing Biomerk Tumorgrafts are conducted like Phase II clinical trials and leading pharmaceutical companies are utilizing the Platform because it is believed to be more predictive than traditional preclinical models.

"We believe that our Biomerk Tumorgrafts accurately predict the outcome of Phase II clinical trials at the early preclinical stage. This provides an enormous advantage versus traditional preclinical models. By testing the BPU Agent against panels of Biomerk Tumorgrafts from several different cancer types, we should be able to identify the compound's best application, predict the outcome of Phase II human trials and, if appropriate, discover biomarkers that may accelerate its clinical development," stated Champions Biotechnology's Chief Scientific Officer, Manual Hidalgo, M.D., Ph.D.

Champions Biotechnology's BPU Agent is an antimitotic inhibitor that targets MAPT (Microtubule-Associated Protein Tau) deficient tumors, a common feature of solid tumors (Molecular Cancer Therapeutics, 2007; 6(5): 1509- 1516). The Company, in exchange for 550,000 restricted shares of its common stock, was assigned all the rights in the U.S. and in foreign countries to the applications for these inhibitors developed at Johns Hopkins University by their inventors Drs. Saeed Khan, Gurulingappa Hallur, Manuel Hidalgo and Antonio Jimeno.

For more information regarding Champions Biotechnology's growing business and recent news, please visit http://www.championsbiotechnology.com.

About Champions Biotechnology, Inc.

Champions Biotechnology, Inc. is engaged in the development of advanced preclinical platforms and predictive tumor specific data to enhance and accelerate the value of oncology drugs. The Company's Preclinical Platform is a novel approach based upon the implantation of primary human tumors in immune deficient mice followed by propagation of the resulting xenografts (Biomerk Tumorgrafts(TM)) in a manner that preserves the biological characteristics of the original human tumor. The Company believes that these Tumorgrafts closely reflect human cancer biology and their response to drugs is more predictive of clinical outcomes in cancer patients.

Champions Biotechnology leverages its preclinical platform to evaluate drug candidates and to develop a portfolio of novel therapeutic candidates through pre-clinical trials. As drugs progress through this early stage of development, the Company plans to sell, partner or license them to pharmaceutical and/or biotechnology companies, as appropriate. The Company also offers its predictive preclinical platform and tumor specific data to physicians for personalized patient care and to companies for evaluation of oncology drugs and drug candidates in models that integrate prognostic testing with biomarker discovery.

Champions Biotechnology is dedicated to enhancing preclinical development tools, accelerating development and valuation of oncology drugs, and advancing personalized treatment with a goal to improve the lives of cancer patients globally.

This press release contains "forward-looking statements" (within the meaning of the Private Securities Litigation Act of 1995) that inherently involve risk and uncertainties. Champions Biotechnology generally uses words such as "believe," "may," "could," "will," "intend," "expect," "anticipate," "plan," and similar expressions to identify forward-looking statements. One should not place undue reliance on these forward-looking statements. The Company's actual results could differ materially from those anticipated in the forward-looking statements for many unforeseen factors. See Champions Biotechnology's Form 10-KSB for the fiscal year ended April 30, 2007 for a discussion of such risks, uncertainties and other factors. Although the Company believes the expectations reflected in the forward-looking statements are reasonable, they relate only to events as of the date on which the statements are made, and Champions Biotechnology's future results, levels of activity, performance or achievements may not meet these expectations. The Company does not intend to update any of the forward-looking statements after the date of this press release to conform these statements to actual results or to changes in Champions Biotechnology's expectations, except as required by law.

CHAMPIONS BIOTECHNOLOGY, INC. WEB SITE: http://www.championsbiotechnology.com


'/>"/>
SOURCE Champions Biotechnology, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Related medicine technology :

1. Champions Biotechnology and Concordia Pharmaceuticals Complete Service Agreement and Begin Preclinical Evaluation of Oncology Drugs
2. TaiGen Biotechnology Successfully Completes Patient Recruitment for Phase II Trial of Nemonoxacin for Treatment of Adult Community Acquired Pneumonia (CAP)
3. Sangamo BioSciences and Sigma-Aldrich Announce Nature Biotechnology Study Demonstrating Zinc Finger Technology for Modification of Human Stem Cells
4. Lixte Biotechnology Holdings, Inc. Announces Completion of Private Placement
5. Lixte Biotechnology Holdings Announces That Anti-Cancer Activity Against Glioblastoma in an Animal Model Was Reported at the Annual Meeting of the American Association of Cancer Research
6. Genetic Engineering & Biotechnology News Reports on the Growing Role of Ion-Channel Studies in Global Biotech R&D
7. Par Pharmaceutical Begins Shipment of Additional Dosage Strength of Generic TOPROL-XL(R)
8. MacroGenics Begins Global Phase 2/3 Protege Study in Recent-onset Type 1 Diabetes Mellitus
9. Enrollment Begins on Human PK Study for Medidur(TM) FA
10. Vical Begins Phase 1 Trial of DNA Vaccine Against H5N1 Pandemic Influenza
11. Sucampo Pharmaceuticals, Inc. Begins Pivotal Phase III Studies of Oral Lubiprostone to Treat Opioid-Induced Bowel Dysfunction (OBD)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... , 11 de fevereiro de 2016  A ... sua fábrica de soroalbumina bovina (BSA -- ... fábrica fica na Ilha Norte da Nova Zelândia, ... e estabelecido na fábrica da Proliant nos EUA, ... O projeto e instalação dos equipamentos foram feitos ...
(Date:2/11/2016)... February 11, 2016 Breast Cancer Therapeutics ... Asia-Pacific (APAC) breast cancer market will ... billion by 2021, at a Compound Annual Growth Rate (CAGR) ... Markets to 2021 - states that the ... expansion from $1.9 billion in 2014 to $3.4 billion by ...
(Date:2/11/2016)... , February 11, 2016 ... at Worldwide Clinical Trials, will present at this year,s Summit ... the Hyatt Regency in Miami, FL. ... partnerships to optimize study execution, supporting SCOPE,s "Improving Site Study ... take place on Thursday, Feb. 25 at 11:05 a.m. ...
Breaking Medicine Technology:
(Date:2/11/2016)... ... February 11, 2016 , ... ... a master charity program created to assist the people of their local community. ... with nonprofit organizations and community leaders. Their hope is to bring awareness to ...
(Date:2/11/2016)... ... February 11, 2016 , ... Duterte Insurance Group, serving the ... a new charity campaign to raise funds for Ronald McDonald House Charities. On ... https://donate.rmhc.org/ . , Ronald McDonald House (RMH) is an internationally renowned nonprofit organization ...
(Date:2/11/2016)... VA (PRWEB) , ... February 11, 2016 , ... ... its new office in the heart of Old Town at 108 South Columbus St, ... and businesses the highest level of medical care in the convenience of their homes, ...
(Date:2/11/2016)... Denver, CO. (PRWEB) , ... February 11, 2016 ... ... American people have become more actively engaged in health and wellness best practices ... the importance of riding this trend. February is American Heart Month, which acts ...
(Date:2/10/2016)... ... 10, 2016 , ... President Obama’s budget proposal yesterday enables ... medical services via telehealth, estimated to generate more than $160 million in savings ... many years. Although there is more to be done, this represents an ...
Breaking Medicine News(10 mins):