Navigation Links
Cerulean Pharma to Present Data on CRLX101's HIF-1a Inhibition at the American Association for Cancer Research Annual Meeting
Date:4/4/2013

CAMBRIDGE, Mass., April 4, 2013 /PRNewswire/ -- Cerulean Pharma Inc., a leader in dynamically tumor-targeted nanopharmaceuticals, today announced that researchers will present both pre-clinical and clinical data on Cerulean's Phase 2 candidate, CRLX101, in sessions at the American Association for Cancer Research (AACR) Annual Meeting. Among the findings, Cerulean will share clinical data from a study evaluating synergy between CRLX101 and Avastin® (bevacizumab).

(Logo:  http://photos.prnewswire.com/prnh/20130107/NE37515LOGO )

In multiple animal models, CRLX101 inhibits hypoxia-inducible factor 1a (HIF-1a), which is involved in cancer survival mechanisms, and which is up-regulated in the hypoxic conditions created by anti-angiogenic drugs. Animal models suggest that CRLX101 is synergistic with multiple anti-angiogenic drugs, and this hypothesis is being tested in a clinical trial combining CRLX101 with Avastin, the leading anti-angiogenic medicine.

Dr. Stephen M. Keefe , the Ann B. Young Assistant Professor in Cancer Research at the Perelman School of Medicine at the University of Pennsylvania, will present a poster entitled A Phase Ib-2a Study Evaluating the Nanopharmaceutical CRLX101 in Combination with Bevacizumab (April 9, 8:00 am – 12:00 pm) on a clinical trial studying synergy between CRLX101 and Avastin when combined to treat patients with advanced renal cell carcinoma. Dr. Keefe, who practices at the Abramson Cancer Center of the University of Pennsylvania, will present data showing that the CRLX101-Avastin combination has been well tolerated in six patients treated to date with no dose limiting toxicities observed. Additional patients are being enrolled in the study to confirm combinability and to assess efficacy.

"The pre-clinical data for CRL
'/>"/>

SOURCE Cerulean Pharma Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Cerulean Pharmas Lead Candidate Selected as a "Top 10 Oncology Project to Watch"
2. Cerulean Announces First Patient Dosed in Phase 2 Study of CRLX101 in Ovarian Cancer
3. Merrimack Pharmaceuticals Announces Top-Line Results From A Single Arm Phase 2 Advanced Lung Cancer Study In Patients With Resistance To An Anti-EGFR Tyrosine Kinase Inhibitor
4. Valeant Pharmaceuticals Provides Update to Recent Event
5. X-BODY Announces Multi-Million Dollar Development Alliance With Jiangsu Hengrui Medicine Co., Ltd., A Leading Pharmaceutical Company In China, To Develop Novel Therapeutic Antibodies For AMD
6. Oramed Pharmaceuticals Granted Japanese Patent for its Core Technology in Oral Delivery of Proteins
7. Valeant Pharmaceuticals And Obagi Medical Products Agree On An Increased Offer Price Of $24.00 Per Share In Cash
8. DFH Pharma, USA Partners with Hetero Group, INDIA to Develop 2nd Generation HIV Maturation Inhibitor Drugs
9. Collegium Pharmaceutical Names Douglas Carlson to Vice President of Business Development
10. Kentucky Health Cooperative To Partner With ProCare Rx For Pharmacy Benefit Management
11. Simcere Pharmaceutical Group Announces its Special Committees Engagement of Financial Advisor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/22/2014)... , Nov. 21, 2014 MEDITE Group acquired by ... months and the 3 rd quarter sales ended September ... was $448,000 for the nine months ended September 2014 and ... though our 3 rd quarter is usually a seasonable ... from July into September for many countries worldwide, we are ...
(Date:11/22/2014)... 2014 Research and Markets  has announced the ... Report, 2014-2017" report to their offering. ... recombinant protein drug market has been expanding rapidly owing ... the like. During 2005-2013, sales of recombinant protein drugs ... of 19.1%, and it is projected that ...
(Date:11/21/2014)... Nov. 21, 2014  Alere Inc. (NYSE: ... has appointed Juliet Cunningham as Vice President, ... be responsible for driving communications with the investment community. ... series of changes to increase shareholder value, it is ... said Namal Nawana, Chief Executive Officer. "We are delighted ...
Breaking Medicine Technology:CytoCore Inc. / MEDITE Cancer Diagnostics, Inc. Reports Record YTD and 3rd Quarter Sales 2CytoCore Inc. / MEDITE Cancer Diagnostics, Inc. Reports Record YTD and 3rd Quarter Sales 3China Recombinant Protein Drug Industry Report, 2014-2017 2China Recombinant Protein Drug Industry Report, 2014-2017 3Alere Appoints Juliet Cunningham to Lead Investor Relations 2
... annual meeting recombinant factor, VIIa-albumin fusion protein seen ... treatment option for hemophilia patients with inhibitors, ... of a pre-clinical study that show for the first time ... albumin, prolonging the,half- life of this therapeutic protein while retaining ...
... Vanderbilt Medical Center is,seeking local residents with ... a national clinical study evaluating an investigational,device, the ... Tennessee., The TANTALUS System is an implantable ... a person eats. The primary objective of the,randomized, ...
Cached Medicine Technology:CSL Behring Study in Animal Models Shows Feasibility of Developing a Half-Life Extended Recombinant FVIIa that Retains Biologic Activity 2CSL Behring Study in Animal Models Shows Feasibility of Developing a Half-Life Extended Recombinant FVIIa that Retains Biologic Activity 3Vanderbilt Medical Center Seeks Middle Tennesseans with Type 2 Diabetes Who are Overweight for National Clinical Trial 2
(Date:11/23/2014)... November 23, 2014 To show thanks to ... new collection of white evening dresses for weddings. ... workers 24/7. , iFitDress.com is a distinguished dress manufacturer, and ... supported by worldwide customers for a very long time. The ... where a customer will be able to buy not only ...
(Date:11/23/2014)... (PRWEB) November 23, 2014 “BlackVue” was ... Tech Report , which features the latest and coolest ... expert and reporter for NewsWatch, conducted the product review ... unique and powerful options in the car camera industry. ... and it can be hard to find the one ...
(Date:11/23/2014)... (PRWEB) November 23, 2014 Today ... reimbursement for small businesses, announced their new on ... End of Employer-Provided Health Insurance. , ... the greatest financial risk facing most American families. ... employers, small and large, when it comes to ...
(Date:11/22/2014)... 2014 Recently, UWDress.com, a successful wedding dress ... guest attire in order to prepare for the wedding ... to 70% off. , UWDress.com is a reliable company ... beautiful, especially the new items -- formal wedding guest attire. ... current market, including superstar and princess. As one of the ...
(Date:11/22/2014)... (PRWEB) November 22, 2014 Setria® ... Administration (TGA) approved it for use “as a ... and listed within the Therapeutic Goods (Listing) Notice ... , Kyowa Hakko’s Setria® Glutathione will be exclusivity ... specialist that sources and imports fine chemicals to ...
Breaking Medicine News(10 mins):Health News:iFitDress.com: Wonderful White Evening Dresses Now Available 2Health News:A Leader in Front and Rear Facing In-Car Cameras was Featured on NewsWatch Television on October 30, 2014 2Health News:Zane Benefits, Inc. Announces New Webinar on The End of Employer-Provided Health Insurance Now Available On-Demand! 2Health News:Formal Wedding Guest Attire Added to UWDress.com 2Health News:Setria® Glutathione Now Available in Australia 2Health News:Setria® Glutathione Now Available in Australia 3
... Dec. 2 TeamHealth ( www.teamhealth.com ) expands its presence ... of Naples, LLC (EPN). Since January 2002, EPN has ... the emergency facilities at the Downtown Naples Hospital, North Naples ... staffing for two stand-alone urgent care clinics in Naples and ...
... official congress of the European Association of Echocardiography (EAE), ... where techniques of non-invasive diagnostic imaging will be presented. ... this year,s Congress, with the latest evidence highlighting the ... such rapid development in imaging techniques, it is likely ...
... ... available in early 2010 from Aerius International Ltd. , ... (PRWEB) December 2, 2009 -- Revolutionary new ... early 2010 from Aerius International Ltd. The technology was recently honored with a Green ...
... The American Health Information Management Association,s Board of ... the next chief executive of the 55,000-member health information ... experience includes academia, systems management, strategic expertise, governance and ... to take office January 13, 2010. , "Dr. Dowling ...
... , , Ad in Today,s ... 2 If the Catholic bishops have their way, ... under threat. The pressure that the US bishops have brought to ... ad in this morning,s Washington Post warns of the likely ...
... Proving true the old adage that "The sum is ... (THHMHS) is partnering with the U.S. Marine Corps Reserves Toys ... brighter for many area families. The organizations are combining ... other non-perishable food items, culminating in a final event on ...
Cached Medicine News:Health News:TeamHealth Acquires Emergency Physicians of Naples, LLC 2Health News:Media alert: EUROECHO 2009 2Health News:New AERIUS Cell Phones Direct Microwave Signals Away from Users 2Health News:Dr. Alan F. Dowling Named AHIMA's Next Chief Executive Officer 2Health News:Everybody's Healthcare Is Threatened by Catholic Bishops' Interference 2Health News:Texas Health Harris Methodist Hospital Southlake Joins With U.S. Marine Corps Reserves Toys for Tots to Spread Holiday Cheer 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: