Navigation Links
Cerulean Announces First Patient Dosed in Phase 2 Study of CRLX101 in Ovarian Cancer
Date:7/23/2012

CAMBRIDGE, Mass., July 23, 2012 /PRNewswire/ -- Cerulean Pharma Inc., a leader in developing dynamically tumor-targeted nanopharmaceuticals, today announced that the first patient has been dosed in a Phase 2 study of its lead candidate, CRLX101, in platinum-resistant ovarian cancer patients.

Having completed enrollment of a 150-patient randomized Phase 2 study in advanced non-small cell lung cancer, Cerulean is beginning to capitalize on the breadth of the CRLX101 opportunity by expanding its development into additional tumor types with several studies conducted by leading investigators.  This newly opened trial is designed to evaluate the activity of CRLX101, a nanopharmaceutical that inhibits both topoisomerase 1 and hypoxia-inducible factor-1 alpha, in ovarian cancer patients whose disease has progressed following standard first-line platinum-based therapy.  Current approved second-line therapy for ovarian cancer includes use of the topoisomerase 1 inhibitor, topotecan, which has limitations.  The study is being conducted at the Massachusetts General Hospital and led by principal investigator Carolyn Krasner, M.D., in cooperation with the Dana Farber Cancer Institute, Brigham and Women's Hospital, and Beth Israel Deaconess Medical Center.  

"Not only do women with advanced stage ovarian cancer have limited treatment options, but they also suffer from many disease-related symptoms and treatment-related side effects," said Dr. Krasner.  "This study will enable us to evaluate the potential use of CRLX101 as a treatment option for those patients." 

"This trial is intended to build on our current clinical data and determine if CRLX101 can offer ovarian cancer patients a new treatment option," said Edward Garmey, M.D., chief medical officer of Cerulean.  "We are excited to partner with Dr. Krasner and to expand the development strategy of CRLX101 in an indication with such high unmet needs."

About CRLX101

CRLX101 is an investigational anti-cancer agent that is a dual inhibitor of topoisomerase 1 and hypoxia-inducible factor-1 alpha.  CRLX101 is a dynamically tumor-targeted nanopharmaceutical designed to concentrate in tumors, prolonging drug exposure at the site of action.  Significant anti-tumor activity has been observed across a wide range of cancers in animal models.  CRLX101 is currently in Phase 2 clinical development.  More information on CRLX101 clinical studies can be found at www.clinicaltrials.gov.

About Cerulean Pharma Inc.

Cerulean Pharma Inc. is a clinical-stage company specializing in the development of dynamically tumor-targeted nanopharmaceuticals.  Cerulean is applying its proprietary nanopharmaceutical platform to advance a new class of therapeutic agents to address significant unmet medical needs.  With an initial focus in oncology, the Company's technology platform can be applied to a wide range of drug molecules, ranging from small molecules to peptides and RNAs.  Cerulean is privately financed and funded by experienced healthcare investors, including Polaris Venture Partners, Venrock, Lilly Ventures, Lux Capital, Bessemer Venture Partners, and CVF, LLC.  Cerulean is located in Cambridge, Massachusetts.  For more information, please visit the Company's website at http://www.ceruleanrx.com.

Media Contacts:
Schwartz MSL
Benjamin Navon/Kathy Vigneault
cerulean@schwartzmsl.com
+1 781-684-0770


'/>"/>
SOURCE Cerulean Pharma Inc.
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. K-V Pharmaceutical Company Announces Additional Notification from NYSE Regarding Listing Criteria
2. Kraton Performance Polymers, Inc. Announces Second Quarter 2012 Earnings Release Conference Call and Webcast and 2012 Investor Day and Webcast
3. Rochester Medical Announces Third Quarter 2012 Earnings Conference Call Friday, July 27, 2012
4. Hologic Announces Pricing Of Financing In Connection With Acquisition Of Gen-Probe
5. Anthera Pharmaceuticals Announces Pricing of Public Offering of Common Stock
6. China Health Resource Announces Go Global Initiative For New Product Introductions
7. Anthera Pharmaceuticals Announces Proposed Public Offering of Common Stock
8. PDI, Inc. Announces Client FDA Product Approval Related to Previously Disclosed Contract
9. Ampio Pharmaceuticals Announces Closing of Public Offering
10. Boston Scientific Announces Promising Clinical Data on New Products at the International Spine Intervention Society 20th Annual Scientific Meeting
11. Trovagene, Inc., Announces Issuance of U.S. Patent for NPM Mutants to Diagnose and Monitor Acute Myeloid Leukemia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2020)... ... February 10, 2020 , ... Aspire Regenerative, a ... to patients. , EMSculpt is an FDA-approved treatment designed to burn fat ... thighs, calves, biceps, and triceps. The EMSculpt machine utilizes HIFEM® (High-Intensity Focused Electromagnetic) ...
(Date:2/10/2020)... (PRWEB) , ... February 10, 2020 , ... ... A. James, MS, RDN, has been selected as the chief of Nutrition and ... for all food service operations and clinical nutrition programs for the health care ...
(Date:2/10/2020)... ... 2020 , ... SentryHealth announced today the expansion ... clinics. Focused on leading innovation in the treatment of chronic disease, Healthstat will ... employee health clinics. Healthward delivers greater insight into eligibility for chronic care management ...
Breaking Medicine Technology:
(Date:2/10/2020)... ... February 10, 2020 , ... Buxton is ... company’s healthcare division. In this role, Nikki will support Buxton’s current and prospective ... healthcare product development. , “The healthcare industry is increasingly understanding the importance ...
(Date:2/10/2020)... , ... February 10, 2020 , ... ... has received 510(k) clearance for use with the Legacy™ and InterActive™ systems and ... combine ideal esthetics for your patients and more freedom of choice for your ...
(Date:2/10/2020)... (PRWEB) , ... February 10, 2020 , ... ... management of chronic cardiometabolic conditions across populations, today announced its founder and chief ... HIMSS’ Most Influential Women in Health IT . Established in 2016, the ...
(Date:2/10/2020)... (PRWEB) , ... February 10, 2020 , ... Real ... and the company that started a real food revolution in the medical community, is ... an extraordinary member of the feeding tube community each year during Feeding Tube ...
(Date:2/9/2020)... (PRWEB) , ... February 08, 2020 , ... Dr. Ezzat ... Dr. Nina Minagawa sent out a message to her professional network calling for support ... call. Both Moghazy and now RYM Director Dr. Minagawa have both been instrumental in ...
Breaking Medicine News(10 mins):