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Ceregene Initiates a New Controlled Phase 2b Trial of CERE-120 for Parkinson's Disease
Date:10/19/2010

further disease progression, and may therefore represent a significant advancement in the treatment of patients for whom existing treatments inevitably fail as their disease progresses."

"This new, improved dosing approach we have developed to account for functional changes in Parkinson's disease neurons should assure that adequate neurturin protein is expressed throughout the degenerating nigrostriatal system. Our nonclinical studies suggest this may significantly enhance the biological effects and therefore the clinical benefit of CERE-120," stated Raymond T. Bartus, Ph.D., Ceregene's executive vice president and chief scientific officer.

"The revised CERE-120 dosing procedure appears safe, to date, and our investigators have been able to implement the dosing protocol with no surgical complications," added Joao Siffert, M.D., vice president and chief medical officer at Ceregene.

About CERE-120 and its Potential for Treating Parkinson's Disease

CERE-120 is composed of an adeno-associated virus (AAV) vector carrying the gene for neurturin, a naturally occurring protein known to repair damaged and dying dopamine-secreting neurons, keeping them alive and restoring normal function. Neurturin is a member of the same protein family as glial cell-derived neurotrophic factor (GDNF). The two molecules have similar pharmacological properties, and both have been shown to benefit the dopamine neurons in the substantia nigra that degenerate in Parkinson's disease. Degeneration of these neurons is responsible for the major motor impairments of Parkinson's disease. CERE-120 has been delivered by stereotactic injection to the terminal fields, i.e., the ends of the degenerating neurons, located in an area of the brain called the putamen. The cell bodies for these same neurons are located in a different area of the brain, called the substantia nigra, and the amended dosing regimen being employed in the ongoing Phase 2b trial calls for admi
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SOURCE Ceregene, Inc.
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