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Ceregene Completes Enrollment of Second Phase 2 Study of CERE-120 for the Treatment of Parkinson's Disease
Date:12/1/2011

rsity of Pennsylvania; Columbia University Medical Center; Rush University Medical Center; Beth Israel Medical Center, NY; and Mount Sinai Medical Center, NY.

About CERE-120 and its Application to Treating Parkinson's Disease
CERE-120 is composed of an adeno-associated virus (AAV) vector carrying the gene for neurturin, a naturally occurring protein known to repair damaged and dying dopamine-secreting neurons, keeping them alive and restoring normal function.  Neurturin is a member of the same protein family as glial cell-derived neurotrophic factor (GDNF).  The two molecules have similar pharmacological properties, and both have been shown to benefit the midbrain dopamine neurons that degenerate in Parkinson's disease.  Degeneration of these neurons is responsible for the major motor impairments of Parkinson's disease.  CERE-120 is delivered by stereotactic injection to the terminal fields (i.e., the ends of the degenerating neurons), located in an area of the brain called the putamen, as well as the cell bodies for these same neurons, located in a different area of the brain, called the substantia nigra.  Once CERE-120 is delivered to the brain, it provides stable, long-lasting expression of neurturin in a controlled and highly targeted fashion.

About Parkinson's Disease
Parkinson's disease is a progressive movement disorder that affects a million people in the United States.  Its main symptoms, stiffness, tremors and slowed movements and gait, are caused by a loss of dopamine-containing nerve cells in the substantia nigra, which project their axons to the putamen.  Dopamine is a neurotransmitter involved in controlling movement and coordination, so Parkinson's patients exhibit a progressive inability to initiate and control physical movements.  There is currently no treatment that can reverse the degeneration of these neurons, let alone cure Parkinson's disease.


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SOURCE Ceregene, Inc.
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