Navigation Links
Ceregene Completes Enrollment of Second Phase 2 Study of CERE-120 for the Treatment of Parkinson's Disease
Date:12/1/2011

to recognize the need to inject CERE-120 directly into the substantia nigra, thus reducing dependency on retrograde transport."  Additionally, because of the safety record thus far established with CERE-120, the current Phase 2b study injected a 4-fold higher CERE-120 dose into the putamen, compared to prior studies.  "These dosing changes are intended to help assure that the entire degenerating neuron is exposed to sufficient neurotrophic factor, stimulating a more robust neurotrophic response, which in turn, should further enhance and accelerate neuronal repair and clinical benefit," continued Dr. Bartus. 

Ceregene's previous Phase 2a clinical study of CERE-120 demonstrated "proof of concept", showing efficacy on a number of secondary clinical motor and quality of endpoints, with no measurement similarly favoring the sham control treatment.  While that study missed the primary endpoint at 12 months post treatment, a statistically significant improvement from CERE-120 was seen on this measure at 15 and 18 months, post treatment (p=0.023).  Moreover, even more secondary endpoints showed benefit at these longer, post-treatment time points.  The current Phase 2b study will analyze patient outcomes following 15 to 24 months post treatment.  The primary endpoint in both Phase 2 trials is the "UPDRS off" score which is a measure of motor function commonly used in clinical trials of Parkinson's disease.  Ceregene expects to report data from the new Phase 2b study near the end of the first quarter of 2013.

This and prior CERE-120 clinical studies were partially supported by a series of generous grants from the Michael J. Fox Foundation for Parkinson's Disease Research.  Participating Medical Centers included The University of California, San Francisco; Emory University; Baylor College of Medicine; Duke University Medical Center; University of Alabama, Birmingham; Stanford University School of Medicine; The Unive
'/>"/>

SOURCE Ceregene, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Ceregene Advances Phase 2b CERE-120 (AAV2-neurturin) Trial in Parkinsons Disease
2. Ceregene Initiates a New Controlled Phase 2b Trial of CERE-120 for Parkinsons Disease
3. Ceregene Presents Long-term Follow-up From Phase 1 Trial of CERE-120 in Parkinsons Disease
4. ETCs Aircrew Training Systems Completes Factory Acceptance Tests for Highly Advanced Suite of Training Equipment for the Republic of Korea Air Force Aeromedical Center
5. Radient Pharmaceuticals Corporation Completes Restructurings with Institutional Investors to Limit Conversions and Stock Sales and Provide for Potential Additional Capital
6. Par Pharmaceutical Completes Acquisition of Anchen
7. Mylan Successfully Upsizes and Completes Refinancing of Credit Facility
8. New Spot Vision Screener Completes School Screening in Less Than Two Hours
9. MAQUET Cardiovascular Completes Acquisition of Atrium Medical Corporation
10. Global Pharm Holdings Group, Inc. Completes Acquisition of Qingdao Likang Pharmaceutical Co., Ltd.
11. Neuralstem Completes Phase Ia in Neuroregenerative Small Molecule Drug, NSI-189, Major Depressive Disorder Trial
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... NEW YORK and LONDON ... in global orthopedic industry are expected to grow at ... consumption in terms of value and volume. Hip, knee ... the developed world while in emerging economies they have ... failure rates are challenging the use of composites. Non-metallic ...
(Date:12/24/2014)... , Dec. 23, 2014 Echo ... medical device company focused on skin permeation, continuous ... Scott W. Hollander has been appointed ... Hollander has more than 20 years of experience ... industries, and most recently served as Vice President, ...
(Date:12/24/2014)... Dec. 23, 2014 ResMed (NYSE: RMD ... action against Chinese medical device manufacturer BMC Medical Co., Ltd. ... that BMC,s masks listed below infringe ResMed,s patents, and entered ... masks in the United States : ... mask , Willow nasal pillows mask , iVolve ...
Breaking Medicine Technology:Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 2Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 3Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 2Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 3ResMed Wins Patent Infringement Lawsuit Against Chinese Manufacturer BMC Medical 2
... , July 29 As of late, the ... been the Lap-Band procedure, a minimally invasive operation in which ... patient,s stomach in order to restrict food capacity and promote ... of Lap Band surgery without the use of ...
... July 29 Asahi Kasei Medical Co., Ltd. is pleased ... BioOptimal™ MF-SL, its new range of microfilters for bioprocessing applications. Designed ... enable biopharmaceutical manufacturers to improve the efficiency and effectiveness of their ... , , ...
Cached Medicine Technology:Sleeve Gastrectomy Procedure With Dr. Michael Feiz Serves as a Highly Effective Alternative to Lap Band Surgery 2Sleeve Gastrectomy Procedure With Dr. Michael Feiz Serves as a Highly Effective Alternative to Lap Band Surgery 3Launch of BioOptimalâ„¢ MF-SL Microfilters for Bioprocessing 2
(Date:12/26/2014)... Yisrayl Hawkins, Pastor at The House of Yahweh in Abilene, ... Ferguson, Missouri unrest. Yisrayl starts his letter by showing the ... has only increased. , He continues in his letter ... is a very specific reason for mankind and covers those ... of rules, or Laws that if followed would ensure that ...
(Date:12/26/2014)... PA (PRWEB) December 26, 2014 Pentec ... Work in the state of Pennsylvania for 2014. The ... first statewide programs of its kind in the country. ... Foundation, the Pennsylvania Department of Community and Economic Development, ... Resource Management and the Central Penn Business Journal. ...
(Date:12/25/2014)... December 26, 2014 The ... combines beauty, strength and durability. Today, the business ... which is valid until Jan. 30, 2015. , ... of traditional hardwood. BambooFlooringChina.com is a well-known brand ... consumers worldwide to find a reliable bamboo flooring ...
(Date:12/25/2014)... the popular online supplier of wedding dresses and special occasion ... black one-shoulder cocktail dresses . In addition, all these elegant ... prices, up to 70% off. , The development ... You know, we have thousands of frequent callers in the ... can visit our website for more details. The current special ...
(Date:12/25/2014)... Hills, California (PRWEB) December 25, 2014 ... her home in Woodland Hills, California after an 8 ... passed away on Christmas Eve evening in her home ... with aggressive metastatic breast cancer. , ... for over forty years, she pioneered and championed many ...
Breaking Medicine News(10 mins):Health News:Yisrayl Hawkins Pleads for Peace in Ferguson and Beyond in New Open Letter 2Health News:Pentec Health Ranks Fourteenth on The Best Places to Work in PA for 2014 2Health News:Pentec Health Ranks Fourteenth on The Best Places to Work in PA for 2014 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:iFitDress.com: Black One-Shoulder Cocktail Dresses for 2015 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 4
... Surface Logix Inc. today announced the initiation of a ... secondary Raynaud's disease. SLx-2101 is a novel , long-acting ... associated with vascular dysfunction such as Raynaud's, a vasospastic ... reduction of blood flow to areas such as the ...
... believe that it is easier to get the child admitted to ... ,People depending on private health care find it inadequate. Often they ... their homes. , ,A new survey suggests that many of ... child. This saves thousands of pounds for the family. The research ...
... its first manned mission to Mars, it has taken its first ... you get rid of the body of a dead astronaut on ... be pulled on a critically ill astronaut who is using up ... employ DNA testing to weed out astronauts who might get a ...
... are used to shock the heart back to normal are found ... out of five fails to work after just ten years. On ... default. , The wire or the lead sometimes shocked ... beating abnormally or completely stopped. ,Many a times it ...
... soup before a meal can help cut back on how much ... State study shows . Results show that when participants in the ... they reduced their total calorie intake at lunch by 20 percent, ... ,"This study expands on previous studies about consuming lower-calorie soup as ...
... Indian origin optician who was part of a British charity, made ... in India. ,Premal Patel, who was part of a ... record 850 eye examinations in a day in the Indian city ... sight difficulties in developing countries. ,'The best moment was ...
Cached Medicine News:Health News:Surface Logix Commences Phase 2a Clinical Trial of SLx-2101 in Raynaud's Disease 2Health News:Inadequate Childcare Hits Wales 2Health News:NASA Gets Ready To Address Tough Questions 2Health News:NASA Gets Ready To Address Tough Questions 3Health News:Taking Low-calorie Soup Before Meal Will Help Cut Calories at Meals 2
circuitGuard™ Products are available in filter or filter/HME styles., ,High quality air cushion anesthesia masks may be packaged with any circuitGuard™ product....
... Since 1991 Intersurgical ... breathing filters, heat and ... oxygen therapy products, hand-held ... range of accessories and ...
... Since 1991 Intersurgical ... breathing filters, heat and ... oxygen therapy products, hand-held ... range of accessories and ...
... has the right product for any patient ... intubated patients to patients with tracheotomies. These ... and critical care applications., ,The Unti-Mist ... patients and staff members. This entire product ...
Medicine Products: