Navigation Links
Cerecor Announces Option to Johns Hopkins Brain Science Institute DAAO Inhibitor Platform

BALTIMORE, Dec. 5, 2012 /PRNewswire/ -- Cerecor Inc today announced that it has signed an option with Johns Hopkins University (JHU) for an exclusive license to develop and commercialize small molecule D-Amino Acid Oxidase inhibitors ("DAAO inhibitors") that were developed at the Johns Hopkins Brain Science Institute ("BSi").

(Logo: )

DAAO inhibitors inhibit the degradation of D-serine, an amino acid which has a central role in the normal function of the glutamate / NMDA system in the human brain.  Growing evidence suggests that deficits in glutamate transmission are central to the neurobiology of schizophrenia.  D-serine, when administered in multi-gram quantities per day, has been shown in multiple studies to improve cognition (executive function) and reduce positive symptoms in schizophrenics. DAAO inhibition in the brain, as a means of increasing D-serine levels, has been a target for treating schizophrenia by major pharmaceutical companies for many years. 

"This approach to improving glutamate transmission is to administer DAAO inhibitors systemically along with small, supplemental doses of D-serine, in a simple and elegant fashion analogous to the use of Sinemet® for the treatment of Parkinson's Disease, as originally conceptualized by Drs. Solomon Snyder and Barbara Slusher," said Dr. Blake Paterson, co-founder and CEO of Cerecor. "The licensing of the DAAO inhibitor platform will be an important milestone in the development of a novel therapeutic for schizophrenic patients, for whom persistent cognition dysfunction is widely recognized as an important gap in current therapeutic approaches."

Under the terms of the agreement with JHU, Cerecor will fund final lead selection efforts already underway at the BSi via a sponsored research agreement. Under the terms of the agreement, once BSi attains pre-specified lead candidate selection criteria, Cerecor plans to sign an exclusive, world-wide license agreement and assume development of the lead DAAO inhibitor candidate(s). JHU will receive an initial license fee and additional payments based upon achievement of specified development and commercialization milestones as well as royalties on net sales.

In 2013, Cerecor intends to complete the technology transfer activities and further examine the development and clinical profile of the lead candidate(s). This strategic evaluation will further inform potential implications for an early development clinical program.

About Cerecor:  Cerecor Inc is a biopharmaceutical company focused on the discovery, development and commercialization of prescription pharmaceuticals whose primary activity is in the human nervous system. We are a Delaware corporation, based in Baltimore and co-founded in April 2011 by Drs. Solomon Snyder, Barbara Slusher, Blake Paterson and Mr. Isaac Blech. Cerecor is focused on translational medicine – the accelerated transfer of technology from the academic laboratory to early human trials, with the mission of commercializing therapeutics that make a difference.

CONTACT: Karen Krumeich, +1-410-522-8707

SOURCE Cerecor Inc
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Dr. Magnus Persson Joins Cerecors Board of Directors
2. Cerecor Announces Initiation of CLIN01-002-A
3. Savient Announces the Election of Robert G. Savage to its Board of Directors
4. Harrington Discovery Institute at University Hospitals Case Medical Center Announces Grant Funding to Physician-Scientists at Major Academic Medical Centers to Support New Drug Development
5. Braincells, Inc. Announces the Successful Completion of a Multiple Ascending Dose Study of BCI-838, a Group II mGluR2/3 Antagonist, and the Companys Plans for a Proof-of-Concept Study in Patients with Treatment-Resistant Depression
6. Tria Beauty, Inc. Announces Partnership with Jenny McCarthy
7. AcelRx Pharmaceuticals Announces Proposed Public Offering Of Common Stock
8. UBM Canon Announces its New Medical Technology Seminar Series
9. Astellas Announces Acceptance of U.S. New Drug Application for Tacrolimus Extended Release Capsules
10. Perrigo Company Announces The Appointment Of Industry Veteran To Executive Vice President And General Manager, Rx
11. Ultra Clean Announces Participation in the Midtown CAP Summit Investor Conference
Post Your Comments:
(Date:11/26/2015)... Research and Markets ( ) has announced ... Outlook to 2019 - Rise in Cardiac Disorders and Growing ... to their offering. Boston ... scientific and others. --> The market ... Boston scientific and others. ...
(Date:11/26/2015)... Nov. 26, 2015 Research and Markets ... the "2016 Future Horizons and Growth Strategies ... Supplier Shares, Country Segment Forecasts, Competitive Intelligence, Emerging ... --> --> This ... the Japanese therapeutic drug monitoring market, including emerging ...
(Date:11/26/2015)... 2015 ... the  "2016 Future Horizons and Growth ... Testing Market: Supplier Shares, Competitive Intelligence, ... --> ) has ... Future Horizons and Growth Strategies in ...
Breaking Medicine Technology:
(Date:11/27/2015)... ... November 27, 2015 , ... The print component of “Supporting ... Atlanta, Dallas, New York, Minneapolis, South Florida, with a circulation of approximately 250,000 ... through a vast social media strategy and across a network of top news ...
(Date:11/27/2015)... ... ... MPWH, the No.1 Herpes-only dating community in the world, revealed that over 50% of its ... 3.7 billion people under the age of 50 – or 67% of the population - ... estimates of HSV-1 infection . , "The data shocks us highly!" said Michelle Li, ...
(Date:11/27/2015)... Wilmington, DE (PRWEB) , ... November 27, 2015 ... ... a member of the well-respected Microsoft Dynamics SL User Group (MSDSLUG). Recognized as ... is an independent group of Microsoft Dynamics SL software users, partners, industry experts ...
(Date:11/27/2015)... MINNEAPOLIS, Minn. (PRWEB) , ... November 27, 2015 ... ... you start failing. Secura Consultants has prided itself for not only fulfilling the ... best income protection solutions at an affordable price and providing top-tier customer service. ...
(Date:11/27/2015)... Los Angeles, CA (PRWEB) , ... November 27, 2015 , ... ... the Commission on Accreditation of Allied Health Education Programs (CAAHEP) awarded accreditation to its ... exclusive list of CAAHEP accredited colleges, as only one of twelve colleges and universities ...
Breaking Medicine News(10 mins):