Navigation Links
Cequent to Present First Proof of Activity of an Oral RNAi Drug in Non-Human Primates at February Keystone Conference
Date:1/6/2009

lly administered bacteria expressing short hairpin RNA (shRNA) against beta-catenin significantly reduced messenger RNA (mRNA) levels of beta-catenin in the mucosa of the small and large intestine, an effect that was reversible after termination of dosing. Samples obtained from the gastrointestinal mucosa indicate that oral tkRNAi treatment was effective in up to 84 percent of animals, and target gene levels were suppressed between 58 to 64 percent compared to control animals. Pharmacokinetic studies verified the presence of the engineered shRNA in the intestinal mucosa, proving successful delivery of the active hairpin RNA component by the bacterial system. Cequent developed the current tkRNAi candidate on the basis of an E. coli delivery platform obtained from the laboratory of Patrice Courvalin at the Institut Pasteur. Cequent is planning to start a Phase I clinical trial for the indication of FAP in 2009.

About Cequent Pharmaceuticals, Inc. (www.cequentpharma.com)

An early-stage biopharmaceutical company, Cequent is pioneering the development of novel therapeutics to prevent and treat a wide range of human disorders - from inflammatory disease to cancer - based on the company's proprietary technology, TransKingdom RNA interference (tkRNAi). Cequent's first products, now in pre-clinical development, are drug candidates targeting colon-cancer prevention and inflammatory bowel disease. The company designed its powerful tkRNAi technology to deactivate specific disease-causing genes safely and effectively, using non-pathogenic bacteria as an engine to produce and deliver RNAi directly into cells. It is based on ground-breaking scientific research originating at the Institut Pasteur (Paris, France) and at the Beth Israel Deaconess Medical Center/Harvard Medical School. A privately held company based in Cambridge, Massachusetts
'/>"/>

SOURCE Cequent Pharmaceuticals
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Cequent Pharmaceuticals Johannes Fruehauf, MD, Ph.D., to be Featured Speaker at RNAi World Congress in Boston - May 2, 2008
2. Vicus Therapeutics to Present at the 234th American Chemical Society National Meeting in Boston, MA
3. Lexicon to Present Research Results at American Chemical Society Meeting Regarding Target of LX1031 Drug Candidate
4. Genaera Corporation Presents Interim Phase 1 Data for Obesity Compound Trodusquemine (MSI-1436) at IBC Conference
5. Quark Pharmaceuticals, Inc. Presented Positive Preclinical Results of Systemic RNAi Compound for Acute Renal Failure (ARF)
6. Intellect Neurosciences, Inc. to Present Data on Alzheimers Vaccine at 13th International Congress of Immunology Conference
7. CV Therapeutics Announces Eight Abstracts Accepted for Presentation at the European Society of Cardiology Congress 2007
8. Pre-clinical Data on Recent Advances with HIV VLP Vaccine Presented at AIDS Vaccine 07 Conference
9. Iomai Announces Data from Phase 2 Field Study of Travelers Diarrhea Vaccine Accepted for Presentation at ICAAC
10. Poniard Pharmaceuticals to Present Updated Results of Picoplatin Phase 2 Small Cell Lung Cancer Trial at 12th World Conference on Lung Cancer
11. New Study Presented at WorldSleep 2007 Demonstrates Ramelteon Has Sustained Efficacy Over Six Months in Adults With Chronic Insomnia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... Sept. 2, 2014 Reportbuyer.com has added ... Markets and Technologies for Molecular Imaging Devices ... AND OBJECTIVES The objectives of this study ... imaging devices used for diagnostic purposes, present global ... all possible market segments as well as forecast ...
(Date:9/2/2014)... 2, 2014  On July 31, the Food and ... it is moving forward to regulate laboratory-developed tests (LDTs). ... laboratories throughout the U.S. will need to comply with ... medical laboratories may subscribe to the strategy to simply ... guidelines in place, it,s widely acknowledged that failure to ...
(Date:9/2/2014)... , Sept. 2, 2014 Reportlinker.com ... available in its catalogue: BRIC ... http://www.reportlinker.com/p02343483/BRIC-Bariatric-Surgery-Devices-Market-Outlook-to-2020.html BRIC ... Summary GlobalData,s new report, ... provides key market data on the BRIC Bariatric ...
Breaking Medicine Technology:Global Markets and Technologies for Molecular Imaging Devices 2Global Markets and Technologies for Molecular Imaging Devices 3Global Markets and Technologies for Molecular Imaging Devices 4Global Markets and Technologies for Molecular Imaging Devices 5Global Markets and Technologies for Molecular Imaging Devices 6Global Markets and Technologies for Molecular Imaging Devices 7Global Markets and Technologies for Molecular Imaging Devices 8Global Markets and Technologies for Molecular Imaging Devices 9Global Markets and Technologies for Molecular Imaging Devices 10Global Markets and Technologies for Molecular Imaging Devices 11Global Markets and Technologies for Molecular Imaging Devices 12Global Markets and Technologies for Molecular Imaging Devices 13Global Markets and Technologies for Molecular Imaging Devices 14Global Markets and Technologies for Molecular Imaging Devices 15Global Markets and Technologies for Molecular Imaging Devices 16Global Markets and Technologies for Molecular Imaging Devices 17Global Markets and Technologies for Molecular Imaging Devices 18Global Markets and Technologies for Molecular Imaging Devices 19Global Markets and Technologies for Molecular Imaging Devices 20Global Markets and Technologies for Molecular Imaging Devices 21Global Markets and Technologies for Molecular Imaging Devices 22Global Markets and Technologies for Molecular Imaging Devices 23Global Markets and Technologies for Molecular Imaging Devices 24Global Markets and Technologies for Molecular Imaging Devices 25FDA Tells Congress It Intends to Regulate LDTs! Web Conference to Provide Straight Talk on Essential Steps Clinical Laboratories and Pathology Groups Will Need to Take to Comply 2FDA Tells Congress It Intends to Regulate LDTs! Web Conference to Provide Straight Talk on Essential Steps Clinical Laboratories and Pathology Groups Will Need to Take to Comply 3BRIC Bariatric Surgery Devices Market Outlook to 2020 2BRIC Bariatric Surgery Devices Market Outlook to 2020 3BRIC Bariatric Surgery Devices Market Outlook to 2020 4BRIC Bariatric Surgery Devices Market Outlook to 2020 5BRIC Bariatric Surgery Devices Market Outlook to 2020 6BRIC Bariatric Surgery Devices Market Outlook to 2020 7BRIC Bariatric Surgery Devices Market Outlook to 2020 8BRIC Bariatric Surgery Devices Market Outlook to 2020 9BRIC Bariatric Surgery Devices Market Outlook to 2020 10
... widely used to treat,inflammatory conditions but can increase the risk of ... of patients on long-term therapy at risk(1,2), - Study of ... with Reclast than with risedronate, a current established therapy(3) ... prevention of ...
... listeners in nine,cities across the United States, ... Show and nine Radio One gospel radio stations ... on Thursday, April 3,2008, benefiting St. Jude Children,s ... States, the national fundraiser helped raise,awareness for St. ...
Cached Medicine Technology:Study Shows Once-Yearly Reclast Better than Risedronate at Increasing Bone Mass in Patients With Osteoporosis Caused by Glucocorticoids 2Study Shows Once-Yearly Reclast Better than Risedronate at Increasing Bone Mass in Patients With Osteoporosis Caused by Glucocorticoids 3Study Shows Once-Yearly Reclast Better than Risedronate at Increasing Bone Mass in Patients With Osteoporosis Caused by Glucocorticoids 4Study Shows Once-Yearly Reclast Better than Risedronate at Increasing Bone Mass in Patients With Osteoporosis Caused by Glucocorticoids 5Study Shows Once-Yearly Reclast Better than Risedronate at Increasing Bone Mass in Patients With Osteoporosis Caused by Glucocorticoids 6The Yolanda Adams Morning Show and Radio One Gospel Stations Raise More Than $1 Million During National Radiothon Benefiting St. Jude 2The Yolanda Adams Morning Show and Radio One Gospel Stations Raise More Than $1 Million During National Radiothon Benefiting St. Jude 3
(Date:9/2/2014)... TUESDAY, Sept. 2, 2014 (HealthDay News) -- Complications ... mastectomy and reconstruction, a new study indicates. ... mastectomy was associated with a slightly higher risk ... The study included more than 18,000 breast cancer ... a double mastectomy with breast reconstruction and were ...
(Date:9/2/2014)... women diagnosed with early-stage breast cancer in California, the ... and 2011, although this procedure was not associated with ... radiation, according to a study in the September 3 ... that surgery for the removal of one breast was ... other options examined in the study. , Randomized trials ...
(Date:9/2/2014)... for their own spread throughout the body by coaxing ... according to a new report by Johns Hopkins scientists. ... Nature Communications , the researchers describe animal and cell-culture ... released by breast cancer cells. These molecules cause lymphatic ... to produce proteins called CCL5 and VEGF. CCL5 attracts ...
(Date:9/2/2014)... Medex Analytic Services is delighted to ... Coral Springs, Fla. due to their greater than forecasted ... for the 2014 year by distinguishing Medex in the ... a higher level of service and professionalism in the ... the industry has responded.” , The location of the ...
(Date:9/2/2014)... Operators in the Community Services industry ... care and counsel for those in need. In 2014-15, ... derive $39.4 billion in revenue, which includes a combination ... five years through 2014-15, the subdivision is forecast to ... of 4.1% in 2014-15. , As the population ages ...
Breaking Medicine News(10 mins):Health News:Complication Rates Low With Mastectomy, Breast Reconstruction: Study 2Health News:Increase seen in use of double mastectomy 2Health News:Increase seen in use of double mastectomy 3Health News:‘Prepped’ by tumor cells, lymphatic cells encourage breast cancer cells to spread 2Health News:Medex Analytic Services Announces New Location for Corporate Headquarters 2Health News:Community Services in Australia Industry Market Research Report Now Updated by IBISWorld 2Health News:Community Services in Australia Industry Market Research Report Now Updated by IBISWorld 3
... NEW YORK, Nov. 10 The United Spinal Association, ... help,center, Ask VetsFirst (http://www.VetsFirst.org ) an interactive gateway ... veterans and their,families., Paul Tobin, President of United ... Veterans Day it is only fitting,that as we honor ...
... According to the American,Diabetes Association there are 23.6 ... have diabetes and approximately one million people are,diagnosed ... million diagnosed,diabetics in the U.S. resulted in $116 ... this growing epidemic, Health Management Corporation,(HMC), a nationally ...
... re-opens in centrally located Family First Health Center; Members now have ... access by public ... Pharmacy celebrated its grand re-opening at 116 South George,Street in York, ... thousands of local York residents who are part of the,Healthy York ...
... combat the problem , , MONDAY, Nov. 10 (HealthDay News) -- ... peanuts, milk and fish is rising rapidly. , At the ... these allergies, according to two reports to be presented Monday ... meeting, in Seattle. , An estimated 3 million children under ...
... N.Y., Nov. 10 In a listing of ... 2008," announced in the,publication,s November 17 edition, Preferred ... nationally, with an overall quality and customer,service score ... 22nd,nationally and its parent company, MVP Health Care,s ...
... CINCINNATI Researchers have generated the first comprehensive ... light on the genetic and molecular dynamics of ... sponsored by the National Institute of Diabetes and ... led by Cincinnati Children,s Hospital Medical Center reports ...
Cached Medicine News:Health News:United Spinal Association Launches VetsFirst.org Help Center: The Next Generation Veterans Service Organization 2Health News:Health Management Corporation Incorporates Clinically Proven Care Diabetes Management Program With Programming From dLife 2Health News:Health Management Corporation Incorporates Clinically Proven Care Diabetes Management Program With Programming From dLife 3Health News:Capital BlueCross Sponsors Healthy Community Pharmacy's Move to New Community-Focused Location in York 2Health News:Capital BlueCross Sponsors Healthy Community Pharmacy's Move to New Community-Focused Location in York 3Health News:Childhood Food Allergies on the Rise 2Health News:Childhood Food Allergies on the Rise 3Health News:Preferred Care Gold Ranked Number One Medicare Advantage Health Plan Nationally In U.S. News & World Report/NCQA 'America's Best Health Plans 2008' Listing 2Health News:Genetic blueprint revealed for kidney design and formation 2Health News:Genetic blueprint revealed for kidney design and formation 3
Developed to meet the infusion needs in NICU, Anesthesia and Critical Care, the AUTO SYRINGE AS50 Infusion Pump delivers precise, controlled infusions....
... MULTI-THERAPY Infusion Pump delivers ... profiles that provide accurate, ... Designed for clinician and ... MULTI-THERAPY Pump enhances safety, ...
... pumps can be customized with selectable performance ... sites and therapies. The COLLEAGUE pumps ... be used for both gravity and pump ... From simple infusions to medication therapies requiring ...
... to the Division of Pathology and Laboratory ... the nation's largest and most comprehensive academic ... nearly 700 employees and more than 40 ... 7 million laboratory test results, interpretations and ...
Medicine Products: