Navigation Links
Cequent to Present First Proof of Activity of an Oral RNAi Drug in Non-Human Primates at February Keystone Conference
Date:1/6/2009

CAMBRIDGE, Mass., Jan. 6 /PRNewswire/ -- Cequent Pharmaceuticals, a pioneer in the development of novel products to deliver RNAi-based treatments to prevent and treat human disease, announced that the company has recently completed a successful toxicology study of its candidate CEQ501, an orally administered tkRNAi therapeutic targeting the primary oncogene (beta-catenin, CTNNB1) in FAP (familial adenomatous polyposis). FAP is an inherited gastrointestinal disease that causes hundreds of polyps to form in the colon. Today, without prophylactic removal of the colon, people with FAP almost inevitably develop colon cancer, and there is no medical treatment available. Cequent will present its findings, the first-ever proof of activity of an oral RNAi drug in non-human primates, in a poster at the Keystone Symposia Conference, Therapeutic Modulation of RNA Using Oligonucleotides. The conference will be held February 8 - 13 in Lake Louise, Alberta Canada.

"Delivery of RNAi into the targeted cells and tissues remains one of the biggest challenges in the development of RNAi-based therapeutics - a new class of drugs designed to work by effectively deactivating the specific gene or genes implicated in the progression of a disease," said Cequent President and CEO, Peter Parker. "We have shown previously in cell-culture assays and in a mouse model for human colon cancer that our tkRNAi technology effectively suppresses beta-catenin, a key oncogene in FAP. These new results are very encouraging, and represent another significant milestone in our work to turn the promise of RNAi into safe and effective therapies to treat devastating diseases, like FAP, and improve the lives of those affected."

The study showed that tkRNAi targeting beta-catenin was well tolerated at high dosing levels, with no product-related adverse events, no increase in serum cytokines, and no gross or histopathologic abnormalities noted. Ora
'/>"/>

SOURCE Cequent Pharmaceuticals
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Cequent Pharmaceuticals Johannes Fruehauf, MD, Ph.D., to be Featured Speaker at RNAi World Congress in Boston - May 2, 2008
2. Vicus Therapeutics to Present at the 234th American Chemical Society National Meeting in Boston, MA
3. Lexicon to Present Research Results at American Chemical Society Meeting Regarding Target of LX1031 Drug Candidate
4. Genaera Corporation Presents Interim Phase 1 Data for Obesity Compound Trodusquemine (MSI-1436) at IBC Conference
5. Quark Pharmaceuticals, Inc. Presented Positive Preclinical Results of Systemic RNAi Compound for Acute Renal Failure (ARF)
6. Intellect Neurosciences, Inc. to Present Data on Alzheimers Vaccine at 13th International Congress of Immunology Conference
7. CV Therapeutics Announces Eight Abstracts Accepted for Presentation at the European Society of Cardiology Congress 2007
8. Pre-clinical Data on Recent Advances with HIV VLP Vaccine Presented at AIDS Vaccine 07 Conference
9. Iomai Announces Data from Phase 2 Field Study of Travelers Diarrhea Vaccine Accepted for Presentation at ICAAC
10. Poniard Pharmaceuticals to Present Updated Results of Picoplatin Phase 2 Small Cell Lung Cancer Trial at 12th World Conference on Lung Cancer
11. New Study Presented at WorldSleep 2007 Demonstrates Ramelteon Has Sustained Efficacy Over Six Months in Adults With Chronic Insomnia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... Aug. 27, 2014 TWi Pharmaceuticals, Inc. ... from the United States Food and Drug Administration ... for megestrol acetate 125mg/ml oral suspension, the generic ... the first-to-file and under Hatch Waxman rules, it ... exclusivity.  TWi has completed the pre-launch preparation of ...
(Date:8/27/2014)... , Aug. 27, 2014 ... report: Collaborative R&D Terms & ... https://www.reportbuyer.com/product/2276220/Collaborative-RD-Terms--Agreements-in-Pharma-Biotech-and-Diagnostics.html The Collaborative ... and Diagnostics report provides comprehensive understanding and ... and agreements entered into by the worlds ...
(Date:8/27/2014)... , Aug. 27, 2014 ... report: Co-development Terms & Agreements ... https://www.reportbuyer.com/product/2276221/Co-development-Terms--Agreements-in-Pharma-Biotech-and-Diagnostics.html The Co-development ... Diagnostics report provides comprehensive understanding and unprecedented ... entered into by the worlds leading life ...
Breaking Medicine Technology:TWi Pharmaceuticals Receives US FDA Final Approval on Generic Megestrol Acetate 125mg/ml Oral Suspension 2Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics 2Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics 3Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics 4Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics 5Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics 6Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics 7Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics 8Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics 9Co-development Terms & Agreements in Pharma, Biotech and Diagnostics 2Co-development Terms & Agreements in Pharma, Biotech and Diagnostics 3Co-development Terms & Agreements in Pharma, Biotech and Diagnostics 4Co-development Terms & Agreements in Pharma, Biotech and Diagnostics 5Co-development Terms & Agreements in Pharma, Biotech and Diagnostics 6Co-development Terms & Agreements in Pharma, Biotech and Diagnostics 7
... 24, 2011 Bacterin International Holdings, Inc. ... the development of revolutionary bone graft material and antimicrobial coatings ... Singular Research,s Sixth Annual ,Best of the Uncovereds, Conference. The ... in Los Angeles, California. Bacterin,s chairman and CEO ...
... Reportlinker.com announces that a new ... its catalogue: Ophthalmic ... and Cataract Surgery Devices, Minimally Invasive ... the Ophthalmic Surgery Market ...
Cached Medicine Technology:Bacterin to Present at Sixth Annual Singular Research 'Best of the Uncovereds' Conference on October 26, 2011 2Ophthalmic Devices Market to 2017 - Glaucoma and Cataract Surgery Devices, Minimally Invasive Procedures in Ophthalmic Surgery to Drive the Ophthalmic Surgery Market 2Ophthalmic Devices Market to 2017 - Glaucoma and Cataract Surgery Devices, Minimally Invasive Procedures in Ophthalmic Surgery to Drive the Ophthalmic Surgery Market 3Ophthalmic Devices Market to 2017 - Glaucoma and Cataract Surgery Devices, Minimally Invasive Procedures in Ophthalmic Surgery to Drive the Ophthalmic Surgery Market 4Ophthalmic Devices Market to 2017 - Glaucoma and Cataract Surgery Devices, Minimally Invasive Procedures in Ophthalmic Surgery to Drive the Ophthalmic Surgery Market 5Ophthalmic Devices Market to 2017 - Glaucoma and Cataract Surgery Devices, Minimally Invasive Procedures in Ophthalmic Surgery to Drive the Ophthalmic Surgery Market 6Ophthalmic Devices Market to 2017 - Glaucoma and Cataract Surgery Devices, Minimally Invasive Procedures in Ophthalmic Surgery to Drive the Ophthalmic Surgery Market 7Ophthalmic Devices Market to 2017 - Glaucoma and Cataract Surgery Devices, Minimally Invasive Procedures in Ophthalmic Surgery to Drive the Ophthalmic Surgery Market 8Ophthalmic Devices Market to 2017 - Glaucoma and Cataract Surgery Devices, Minimally Invasive Procedures in Ophthalmic Surgery to Drive the Ophthalmic Surgery Market 9Ophthalmic Devices Market to 2017 - Glaucoma and Cataract Surgery Devices, Minimally Invasive Procedures in Ophthalmic Surgery to Drive the Ophthalmic Surgery Market 10Ophthalmic Devices Market to 2017 - Glaucoma and Cataract Surgery Devices, Minimally Invasive Procedures in Ophthalmic Surgery to Drive the Ophthalmic Surgery Market 11Ophthalmic Devices Market to 2017 - Glaucoma and Cataract Surgery Devices, Minimally Invasive Procedures in Ophthalmic Surgery to Drive the Ophthalmic Surgery Market 12Ophthalmic Devices Market to 2017 - Glaucoma and Cataract Surgery Devices, Minimally Invasive Procedures in Ophthalmic Surgery to Drive the Ophthalmic Surgery Market 13Ophthalmic Devices Market to 2017 - Glaucoma and Cataract Surgery Devices, Minimally Invasive Procedures in Ophthalmic Surgery to Drive the Ophthalmic Surgery Market 14
(Date:8/27/2014)... (PRWEB) August 28, 2014 National ... participate in the Association for Medical Education in Europe ... in Milan, Italy August 30 – September 3, 2014. ... of the international medical education community, share the benefits ... to strengthen resident physician placement in countries throughout the ...
(Date:8/27/2014)... When it comes to the bedroom, most ... sleep without breaking the bank in the process. Regardless of ... mattress set for the master bedroom or simply looking for ... it all during their Labor Day mattress promotion. , This ... best mattresses for the home, while enjoying free delivery. Beyond ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 Millennium Treatment ... a sponsor for Florida Mental Health Counselors Association (FMHCA). ... the new sponsorship is sure to provide. , FMHCA ... needs of Florida’s licensed mental health counselors. The organization ... American Counseling Association (ACA) and since then, it has ...
(Date:8/27/2014)... City, UT (PRWEB) August 27, 2014 ... announces a webinar on compliance tips for administering a ... with health reform in full effect, compliance is top ... As employers transition to individual health insurance and premium ... comply with. , In the 35 minute webinar, Zane ...
(Date:8/27/2014)... Recently, iFitDress.com, a professional company of women’s dresses ... romantic bridal gowns . To top it all ... to 66 percent off) when buying the company’s new ... been updated with these new items. All its online ... all clients can gain an enjoyable shopping experience on ...
Breaking Medicine News(10 mins):Health News:National Resident Matching Program International (NRMPI) to Exhibit at the 2014 AMEE Conference 2Health News:Bedding Mart, Top Mattress Store in Broken Arrow Oklahoma, Announces a Huge Labor Day Sale 2Health News:Millennium Treatment Group Sponsors Florida Mental Health Counselors Association 2Health News:Zane Benefits Announces Upcoming Webinar on Compliance 2Health News:Promotion For Romantic Bridal Gowns Launched By Professional Company iFitDress.com 2
... a new strategy for quicker and more precise detection of ... the way for new tools to detect early stages of ... diseases have proteins specifically linked to them called biomarkers. Identifying ... powerful tool in identifying diseases in their early stages. This ...
... confectionary owes as much to art as it does ... handcraft with large scale industry. Confectionery and ... years of Professor Ferenc Mohos, inside experience to reveal ... applied to this unique industry. "Confectionery is usually ...
... BOSTONThe risk factors for indoor and outdoor falls for older ... Institute for Aging Research of Hebrew SeniorLife, an affiliate of ... the two are combined and may affect how falls prevention ... says senior author Marian T. Hannan, D.Sc., a senior scientist ...
... cancer researchers have identified a genetic signature that ... cell lung cancer,are at high risk for developing ... surgery ("adjuvant chemotherapy"). , "The findings give ... the,appropriate post-operative treatment route to follow. Not all ...
... HealthDay Reporter , TUESDAY, Sept. 7 (HealthDay News) ... have been limited by concerns over the possible development of ... to prevent their infection in the first place. But ... may be a way to administer one particularly cheap and ...
... of Rochester Medical Center researchers are beginning a large, ... prevention program in high schools across New York and ... Sources of Strength, led by Peter Wyman, Ph.D., associate ... by a five-year, $3-million grant awarded by the National ...
Cached Medicine News:Health News:Scientists make leap forward in early detection for Alzheimer's and cancer 2Health News:Confectionery and chocolate engineering: Principles and applications 2Health News:Institute for Aging Research study finds indoor and outdoor fall are different for the elderly 2Health News:Institute for Aging Research study finds indoor and outdoor fall are different for the elderly 3Health News:Researchers identify gene set that shows which patients benefit from chemo after surgery 2Health News:Many HIV-Infected Kids Could Use Cheaper Treatment Safely 2Health News:Many HIV-Infected Kids Could Use Cheaper Treatment Safely 3Health News:Many HIV-Infected Kids Could Use Cheaper Treatment Safely 4Health News:Researchers will test suicide prevention program in high schools 2Health News:Researchers will test suicide prevention program in high schools 3
... polyester, latex-free, thermal transfer wristband for ... Prints images that resist smears and ... mild cleaners, and blood. A time-tested ... and patron management applications. A tamper-evident ...
... thermal wristband that provides automated ID verification ... boost efficiency and accuracy. Meets healthcare patient ... the risk of data left on ribbons ... errors (FDA). Also available with UV varnish, ...
... Laser Sheeted Wristband / ... laser-printable sheets with an ... laser labels that adhere ... clear, fold-over protective window ...
... DataMate Laser Sheeted Wristband ... of laser-printable sheets with ... and laser labels that ... wristbands clear, fold-over protective ...
Medicine Products: