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Ception Therapeutics Initiates Phase II/III Clinical Trial for Its Lead Product Reslizumab in Eosinophilic Esophagitis (EE) in Children
Date:3/5/2008

rs and will enroll approximately 172 patients. For more information on this clinical trial, please visit http://www.clinicaltrials.gov [Identifier: NCT00538434].

About Reslizumab

Reslizumab is a humanized mAb against IL-5. IL-5 plays a crucial role in the maturation, growth and chemotaxis of eosinophils, inflammatory cells implicated in a number of allergic diseases.

About Eosinophilic Esophagitis

Eosinophilic esophagitis (EE) is a disease that has become increasingly recognized in children and adults over the last decade.(1) It is characterized by an accumulation of eosinophils in the esophagus in association with symptoms that frequently mimic gastro-esophageal reflux disease (GERD).(2) Specifically, patients typically report symptoms that include difficulty feeding and failure to thrive in younger children, as well as vomiting, epigastric or chest pain, dysphagia, and food impaction.(2) The diagnosis must be made on the basis of an esophageal biopsy demonstrating the presence of significant numbers of eosinophils, clinical symptoms, and the absence of acid reflux or failure to respond to acid reduction therapy.(1)

Allergic responses have been strongly implicated in the etiology of EE.(1) The overexpression of the cytokine IL-5 by T helper type 2 cells is thought to play a major role in the pathogenesis of the disease.(1) Therapies currently utilized for EE include severely restricted diets, including an elemental formula diet typically administered by nasogastric or gastrostomy tube.(2) There are no approved pharmacologic therapies for EE, although corticosteroids are sometimes administered to patients.

About Ception Therapeutics, Inc.

Ception Therapeutics is a biopharmaceutical company focused on the discovery and development of novel products to address areas of unmet medical need. The Company's pipeline includes reslizumab in clinical development for eosi
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SOURCE Ception Therapeutics, Inc.
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