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Cephalon Signs Option Agreement to Acquire Ception Therapeutics
Date:1/13/2009

ucts that address patient need, which are first-in-class and focus on specialty pharmaceutical markets."

"Today's option agreement is an outstanding corporate achievement for Ception that satisfies our fund raising requirements and provides an excellent partner to advance our novel development programs faster and with greater global reach," said Stephen Tullman, president and CEO, Ception Therapeutics. "Based on our shared experience, commitment, and management philosophies, I have very high expectations that this collaboration will be a win-win for both companies and the patients whom we will serve."

About Reslizumab and Eosinophilic Esophagitis

Reslizumab is a humanized monoclonal antibody (mAb) against interleukin-5 (IL-5). IL-5 plays a crucial role in the maturation, growth and chemotaxis of eosinophils, inflammatory cells implicated in a number of allergic diseases. Granted orphan drug status for pediatric eosinophilic esophagitis by the U.S. Food and Drug Administration, reslizumab currently is being evaluated in a large multi-center Phase IIb/III study.

Eosinophilic esophagitis (EE) is a disease that has become increasingly recognized in children and adults over the last decade. IL-5 is the major cytokine responsible for the eosinophilic inflammation of the esophagus seen in EE. The disease is characterized by an accumulation of eosinophils in the esophagus in association with symptoms that frequently mimic severe gastro-esophageal reflux disease (GERD). Specifically, patients typically report symptoms that include difficulty feeding and failure to thrive in younger children, as well as vomiting, epigastric or chest pain, dysphagia, and food impaction. There are no approved pharmacologic therapies specifically for EE, although corticosteroids sometimes are administered to patients.

About Cephalon, Inc.

Founded in 1987, Cephalon,
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SOURCE Cephalon, Inc.; Ception Therapeutics, Inc.
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