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Cephalon Signs Option Agreement to Acquire Assets from Alba Therapeutics
Date:2/9/2011

Alba Therapeutics.

About Larazotide Acetate and Celiac DiseaseCeliac disease is an autoimmune disorder that is triggered by the ingestion of gluten, which is primarily found in bread, pasta, cookies, pizza crust and other foods containing wheat, barley or rye. People with celiac disease who are exposed to gluten experience an immune reaction in their small intestines, causing damage to the inner surface (villi) of the small intestine, and an inability to absorb certain nutrients.  Signs and symptoms of celiac disease include intestinal pain, bloating, diarrhea and failure to thrive (infants and small children).  These symptoms can be reduced, and sometimes eliminated, by avoiding food that contains gluten.  However, many patients remain symptomatic despite a gluten-free diet, and these patients may benefit from the addition of pharmacotherapy.  

Larazotide acetate is a tight junction modulator.  Tight junctions in a normal bowel are closed except to shed dead cells.  In the presence of gluten in patients with celiac disease, these tight junctions remain open, thus starting an inflammatory cascade within the bowel that eventually destroys the intestinal villa.  Early research suggests larazotide acetate may help keep the tight junctions closed when ingested prior to a meal, thus reducing the inflammatory process in response to gluten.  

About Cephalon, Inc.Cephalon is a global biopharmaceutical company dedicated to discovering, developing and bringing to market medications to improve the quality of life of individuals around the world. Since its inception in 1987, Cephalon has brought first-in-class and best-in-class medicines to patients in several therapeutic areas. Cephalon has the distinction of being one of the world's fastest-growing biopharmaceutical companies, now among the Fortune 1000 and a member of the S&P 500 Index, employing approximately 4,000 people worldwide. The company sells n
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