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Cempra to Present Data on Solithromycin's (CEM-101) Potential Against Urogenital Infections and Multidrug-Resistant Pathogens at ECCMID
Date:4/26/2013

ally transmitted infections
  • Treatment with a 1 gram single dose azithromycin induces high-level macrolide resistance in many cases where eradication fails; drug-resistant strains of M. genitalium are emerging
  • Solithromycin, a new fluoroketolide that is active against other urogenital pathogens, demonstrated antimicrobial activity, in vitro, that was superior to azithromycin and other macrolides
  • Solithromycin may be a promising alternative to current treatments for M. genitalium and its strong activity suggests that the drug could lead to less selection of macrolide-resistant strains of M. genitalium
  • Abstract P 1603, 1:30-2:30 p.m. CEST: Evaluation of disc diffusion testing of solithromycin using Mueller Hinton fastidious medium

    J. Deane, C. Opiela, E. Matuschek, G. Kahlmeter, D. Sahm, K. Keedy, A. Sheets, P. Fernandes

    • Disk diffusion testing is used in the determination of clinical breakpoints to measure pathogen susceptibility to antibiotics
    • This study determined that solithromycin disk diffusion results obtained with the control and clinical strains were comparable with two different disk sources on agar from two different manufacturers indicating that results are likely to be very similar for the target pathogens, regardless of which agar medium (CLSI or EUCAST) is used for testing

    About Cempra, Inc.
    Founded in 2006, Cempra, Inc. is a clinical-stage pharmaceutical company focused on developing antibiotics to meet critical medical needs in the treatment of bacterial infectious diseases. Cempra's two lead product candidates are in advanced clinical development; solithromycin in Phase 3 for CABP and TAKSTA™ (CEM-102) in Phase 2 for prosthetic joint infections.  Both seek to address the need for new treatments targeting drug-resistant bacterial infections in the hospit
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    SOURCE Cempra, Inc.
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