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Cempra to Present Data on Solithromycin's (CEM-101) Potential Against Urogenital Infections and Multidrug-Resistant Pathogens at ECCMID
Date:4/26/2013

(from an enrollment of 28) including from cervical, urethral, rectal and pharyngeal infection sites
  • Solithromycin was well tolerated and was accompanied by only mild gastrointestinal effects
  • Abstract P 1640, 1:30-2:30 p.m. CEST: In vitro and intracellular activity of solithromycin (CEM-101) against clinical isolates of Legionella pneumophila

    J. Mallegol, P. Fernandes, R. Melano, C. Guyard

    • Legionella pneumophila is an important respiratory pathogen
    • Azithromycin and fluoroquinolones are the currently-recommended treatments but resistance to both antibiotics is increasing; cephalosporins are ineffective
    • Solithromycin demonstrated higher in vitro potency against all L. pneumophila isolates than azithromycin

    Abstract P 1593, 1:30-2:30 p.m. CEST: Analysis of solithromycin bactericidal activity against vancomycin-susceptible and vancomycin-resistant enterococci

    J Deane, C. Opiela, D Sahm, K. Keedy, A. Sheets, P. Fernandes

    • Linezolid was the last antibiotic approved to treat enterococcal infections
    • MICs for solithromycin were relatively low compared to linezolid suggesting that a macrolide could be an option to treat these infections
    • Although neither solithromycin nor linezolid demonstrated bactericidal activity, solithromycin almost eradicated one strain, suggesting that solithromycin's spectrum of activity may differ from those of older macrolides and ketolides.

    Abstract P 1638, 1:30-2:30 p.m. CEST: In vitro activity of solithromycin (CEM-101) among azithromycin resistant and susceptible Mycoplasma genitalium strains

    J.S. Jensen , P. Fernandes and M. Unemo

    • Mycoplasma genitalium is a well-known and important cause of sexu
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    SOURCE Cempra, Inc.
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