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Cempra Pharmaceuticals Presents New Data on its Fourth Generation Macrolide, Solithromycin (CEM-101) at the 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
Date:9/16/2011

CHICAGO, Sept. 16, 2011 /PRNewswire/ -- Cempra Pharmaceuticals today announced abstracts to be presented on its fourth generation macrolide and novel fluoroketolide antibiotic, solithromycin (CEM-101), at the 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), September 17 to 20, 2011, in Chicago.  The abstracts provide additional data that demonstrate the safety and routes of administration of CEM-101, a new generation macrolide.  

CEM-101 is a fluoroketolide belonging to the macrolide class and is the first macrolide since azithromycin with the potential for both intravenous (IV) and oral administration. The compound has potent in vitro activity against respiratory pathogens such as pneumococci, including macrolide- and quinolone-resistant strains.  Bacterial pneumonia caused by multi-drug resistant pneumococci has a significant impact on morbidity and mortality due to high treatment failure rates and subsequently increases hospitalization and healthcare costs. CEM-101 has completed Phase 2 trials in community-acquired bacterial pneumonia (CABP) for the oral dosage form and is in Phase 1 for the IV dosage form.

"Data presented at this year's ICAAC conference contributes additional data on the safety, tolerability and dosing profile of our fourth generation macrolide, CEM-101," said Prabhavathi Fernandes, Ph.D., president and chief executive officer of Cempra.  "Our efforts are centered around developing an injectable macrolide that -- causes less pain on injection than traditional macrolides and that provides physicians with the possibility of initiating patients on an antibiotic in the hospital then stepping down therapy to oral administration to send the patient home on the same antibiotic.  In addition, we have extended the structure-side effect relationships of our studies on telithro
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