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Cellular Dynamics Announces Presentations at the Society of Toxicology's 52nd Annual Meeting Demonstrating the Expanding Impact of iPSC-Derived Human Cells on Toxicology Assay Development
Date:3/8/2013

; University of Glasgow and Clyde Biosciences) present data on the utility and suitability of a novel optical platform that when used in conjunction with iCell Cardiomyocytes can assess new chemical entity (NCE)-mediated proarrhythmia with an order of magnitude greater throughput than manual patch clamp methods without loss of sensitivity.

Sirenko, O et al. (Abstract 86, poster 120; Molecular Devices and University of North Carolina - Chapel Hill) describe methods for measuring the impact of drug compounds on iCell Cardiomyocytes' beat rate using fast kinetic fluorescence imaging, thus incorporating high throughput screening in proarrhythmia testing.

Qin, S et al. (Abstract 89, poster 123; Cyprotex and Axion Biosystems) demonstrate the use of multi-well multi-electrode arrays (MEAs) as an effective tool to screen for cardiotoxic liabilities in iCell Cardiomyocytes.

Yego, EK et al. (Abstract 363, poster 628; US Army Medical Research Institute of Chemical Defense) describe the feasibility of using miRNA microarray analysis to assess the effects of chemical warfare nerve agents on iCell Neurons.

Bradley, J et al. (Abstract 901, poster 203; Cyprotex and Axion Biosystems) demonstrate the use of multi-well MEAs to screen seizurogenic compounds on iCell Neurons to predict neural toxicity.

Wolfe, ML et al. (Abstract 1063, poster 508; MPI Research) discuss hepatotoxicity prediction using a high content imaging system to assess drug induced liver injury after treating human hepatocellular carcinoma Hep G2 cells, iCell Hepatocytes, and primary human hepatocytes with a variety of drug compounds.

Wilga, PC et al. (Abstract 1465, poster 522; CeeTox) describe a dual cell model (iCell Cardiomyocytes and HepaRG cells) that utilizes changes in cell health and function following exposure to a drug compound to differentiate heart toxicity from liver toxicity, demonstrating that the combined data predicted cardiac toxicity with greater conf
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