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Cellular Dynamics Announces Commercial Launch of iCell® Endothelial Cells for Vascular-Targeted Drug Discovery
Date:9/20/2011

MADISON, Wis., Sept. 20, 2011 /PRNewswire/ -- Cellular Dynamics International (CDI) today announced the commercial launch of human iCell® Endothelial Cells for use in vascular-targeted drug discovery, tissue regeneration and other life science research.

Endothelial cells make up the lining of blood vessels and thus are an important factor of vascular research across a multitude of disease states.  Endothelial dysfunction is a common promoter of cardiovascular disease, atherosclerosis, inflammation, thrombosis, high blood pressure and more. In addition, endothelial cells separate circulating blood from the brain, an interface known as the blood-brain barrier (BBB). While vital for protecting the brain from bacterial infections, the BBB also presents a major challenge in the delivery of diagnostic and therapeutic agents to the brain.

Unfortunately, current cell models isolated from surgical by-products, cadaveric tissue and immortalized cell lines are not truly reflective of human biology. Additional growth factors are commonly added to cultures to overcome poor growth or attachment issues at the expense of altering endothelial cell function. In addition, these cell models are limited in quantity and exhibit batch-to-batch variability.

iCell Endothelial Cells are derived from human induced pluripotent stem (iPS) cells, actively proliferate, are capable of arranging themselves into tubular formations and exhibit biochemical properties of normal human endothelial cells. Because they are human cells, they better recapitulate human biology and therefore are better predictors of drug candidate responses than current cell models.  CDI manufactures iCell Endothelial Cells in industrial quantities with more than 95% purity, which is ideal for vascular biology research, including revascularization of
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SOURCE Cellular Dynamics International
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