Navigation Links
Cellular Dynamics Announces Commercial Launch of iCell® Endothelial Cells for Vascular-Targeted Drug Discovery
Date:9/20/2011

MADISON, Wis., Sept. 20, 2011 /PRNewswire/ -- Cellular Dynamics International (CDI) today announced the commercial launch of human iCell® Endothelial Cells for use in vascular-targeted drug discovery, tissue regeneration and other life science research.

Endothelial cells make up the lining of blood vessels and thus are an important factor of vascular research across a multitude of disease states.  Endothelial dysfunction is a common promoter of cardiovascular disease, atherosclerosis, inflammation, thrombosis, high blood pressure and more. In addition, endothelial cells separate circulating blood from the brain, an interface known as the blood-brain barrier (BBB). While vital for protecting the brain from bacterial infections, the BBB also presents a major challenge in the delivery of diagnostic and therapeutic agents to the brain.

Unfortunately, current cell models isolated from surgical by-products, cadaveric tissue and immortalized cell lines are not truly reflective of human biology. Additional growth factors are commonly added to cultures to overcome poor growth or attachment issues at the expense of altering endothelial cell function. In addition, these cell models are limited in quantity and exhibit batch-to-batch variability.

iCell Endothelial Cells are derived from human induced pluripotent stem (iPS) cells, actively proliferate, are capable of arranging themselves into tubular formations and exhibit biochemical properties of normal human endothelial cells. Because they are human cells, they better recapitulate human biology and therefore are better predictors of drug candidate responses than current cell models.  CDI manufactures iCell Endothelial Cells in industrial quantities with more than 95% purity, which is ideal for vascular biology research, including revascularization of an organ for tissue regeneration.  

"CDI was able to provide us with the necessary endothelial cells to endothelialize our decellularized organ scaffolds.  The preliminary data look excellent," said Dr. Michael Abecassis, Founding Director of the Comprehensive Transplant Center at Northwestern University's Feinberg School of Medicine.  "We look forward to the continued use of these cells as we strive to develop tissue-engineered solutions to the severe organ shortage currently facing transplantation."

CDI has successfully engaged in pre-launch validation testing with pharmaceutical customers. The cells are useful in a variety of applications that are commonly used in vascular biology research: cell proliferation, cell invasion, and migration, cell adhesion, cell permeability, impedance/resistance and tubular formation.

"If one is interested in developing new therapeutics to treat diseases caused by human endothelial dysfunction, then the best cell model to use is human endothelial cells that recapitulate true biology," said Chris Parker, chief commercial officer of CDI.  "The problem our customers face today is that such cells have not been reproducible or available, and both academic and pharmaceutical researchers have had to make do with inferior models.  Since iCell Endothelial Cells are human and can be manufactured in high quantity, quality, and purity, we anticipate that our customers can make better decisions because their data will be based on better experimental models."

Endothelial cells are the second product CDI has now commercially launched, with neurons to follow later this year. CDI launched the first product ever developed from iPS cells, iCell Cardiomyocytes, in December 2009, just two years after human iPS cell technology was discovered in the University of Wisconsin-Madison laboratory of James Thomson, V.M.D., Ph.D. and Shinya Yamanaka (Tokyo University). Based on strong intellectual property and exclusively licensed patents from several universities, CDI has developed a proprietary process to industrialize the manufacture of virtually any cell in the human body. This capability is designed to aid drug discovery and improve the predictability of drug compound efficacy and toxicity screens early in the pharmaceutical pipeline process before significant time and resources have been invested.  

Robert Palay, chief executive officer of CDI, said, "Launching iCell Cardiomyocytes to the pharmaceutical industry in 2009 was an important step for Cellular Dynamics.  However, the launch of iCell Endothelial Cells shows we have built the infrastructure, expertise, and manufacturing pipeline to create virtually any cell type in the human body.  We look forward to launching many other iPS cell-derived iCell products."

About Cellular Dynamics International, Inc.

Cellular Dynamics International, Inc. (CDI) is a leading developer of next-generation stem cell technologies for drug development and personalized medicine applications.  CDI harnesses the power of pluripotent stem cells and their ability to differentiate into any cell type for world-class drug development tools.  In addition, it is the leader in iPSC technology, the production of pluripotent stem cell lines from adult tissue.  CDI was founded in 2004 by Dr. James Thomson, a pioneer in human pluripotent stem cell research at the University of Wisconsin-Madison.  CDI's facilities are located in Madison, Wisconsin. See www.cellulardynamics.com.


'/>"/>
SOURCE Cellular Dynamics International
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Paper in International Journal of Oncology Reports Alfacells ONCONASE(R) Suppresses Intracellular Oxidative Stress
2. Intra-Cellular Therapies Presents Preclinical Data From Schizophrenia and Sleep Maintenance Programs
3. Intra-Cellular Therapies Initiates Phase 2 Clinical Trial for Sleep Maintenance Insomnia
4. Intra-Cellular Therapies Presents Data on Its Schizophrenia and Cognition in Schizophrenia Programs at the 14th Biennial Winter Workshop on Schizophrenia and Bipolar Disorders
5. Pre-Clinical Data Show Intracellular Pathways Affected by ONCONASE(R)
6. Intra-Cellular Therapies Announces the Discovery of Potent Antidepressant Activity in ITI-007/ITI-722
7. Intra-Cellular Therapies Announces the Discovery of Potent Antidepressant Activity in ITI-007
8. Molecular Discoveries Shed Light on Liver Cancer -- Hepatocellular Carcinoma (HCC)
9. Novel Photoconductive Life Science Research Innovation Enables Rapid, Reproducible, and Non-Invasive Cellular Excitation
10. Seahorse Bioscience Announces the XF96 Extracellular Flux Analyzer for Cellular Bioenergetics
11. Light Sciences Oncology Completes Patient Enrollment in Phase 3 Clinical Trial of Litx as a Treatment for Hepatocellular Carcinoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2016)... Revolutionary technology includes multi-speaker listening ... industry leaders in advanced audiology and hearing aid technology, ... ™, the world,s first internet connected hearing aid that ...      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ) , ... ,world firsts,: , TwinLink™ - the first ...
(Date:6/23/2016)... 23, 2016 The vast majority of dialysis ... facility.  Treatments are usually 3 times a week, with ... including travel time, equipment preparation and wait time.  This ... grueling for patients who are elderly and frail.  Many ... and rehabilitation centers for some duration of time. ...
(Date:6/23/2016)... FRANKLIN, Tenn. , June 23, 2016 ... for automating, integrating and transforming the patient ... launch of several innovative new products and ... depth of its revenue cycle offerings. These ... establish more efficient workflows, remain compliant in ...
Breaking Medicine Technology:
(Date:6/24/2016)... ... ... A recent article published June 14 on E Online details ... to state that individuals are now more comfortable seeking to undergo not only the ... and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians (BHP) notes ...
(Date:6/24/2016)... ... 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. In ... benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued ... Sickle Cell Disease (SCD) is a disorder of the red blood cells, which can ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... Conference and Scientific Sessions in Dallas that it will receive two significant new ... the grants came as PHA marked its 25th anniversary by recognizing patients, medical ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. ... accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, ... and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief ... a minimum wage raise to $12 an hour by 2020 and then adjusting it yearly ... lost value of the minimum wage, assure the wage floor does not erode again, and ...
Breaking Medicine News(10 mins):