Navigation Links
Cellular Biomedicine Group Announces Positive Interim Results from Phase I/IIa Clinical Trial for Treatment of Knee Osteoarthritis (KOA)
Date:9/6/2013

PALO ALTO, Calif., Sept. 6, 2013 /PRNewswire/ -- Cellular Biomedicine Group, Inc. (OTCQB: CBMG) today announced the interim results of its Phase I/IIa clinical trial for human adipose-derived mesenchymal precursor cell (haMPC) therapy for Knee Osteoarthritis (KOA), which tests the safety and efficacy of intra-articular injections of autologous (patient's own) haMPCs in order to reduce inflammation and repair damaged joint cartilage. On schedule for completion in Q4 2013, the interim analysis of the trial has preliminarily demonstrated a significant improvement (P<0.05) from the baseline in clinical scores for SF-36, NRS-11, and WOMAC osteoarthritis indices, and no serious adverse events have been reported.

"We are very pleased with the results of the trial thus far and we look forward to the full data readout before the end of the year," said Wei (William) Cao, PhD, BM, President at Cellular Biomedicine Group. "Knee osteoarthritis severely impacts one's quality of life, and surgical treatment is very costly and invasive. This trial's preliminary results have encouraged us to continue with the study to further test the efficacy of this hopeful therapy to reduce pain, repair knee cartilage and improve quality of life of the patients in the next Phase II trial."

Knee Osteoarthritis in China
There are approximately 57 million people in China suffering from knee osteoarthritis. As drug-based methods of management are ineffective, many patients with this disease will degenerate to the point of requiring invasive artificial joint replacement surgery.

About the Clinical Trial
Cellular Biomedicine Group's Phase I/IIa clinical trial studies the safety and efficacy of CBMG's proprietary adipose-derived progenitor cell (haMPC) - based therapy for knee osteoarthritis. According to the interim analysis of Phase I/IIa for KOA, 24 patients were screened, and 18 of them were eligible for the inclusion criteria and enrolled in the trial with their informed consent. To date, half of the subjects have completed a total of 2 doses of intra-articular injections and the scheduled 6 follow-up observations, and no serious adverse events (SAEs) have been reported.

The trial is conducted by Shanghai's Renji Hospital, a tertiary hospital affiliated to Shanghai Jiao Tong University School of Medicine.

"Our adipose-derived MPC therapy for KOA utilizes our proprietary medical device, the A-Stromal™ Kit," commented Li (Helen) Zhang, BM, Vice President of Technology and Manufacturing at CBMG. "With this patented kit, approved as a medical device by China's SFDA, we use the patient's own haMPC, which negates the need for immunosuppression or donor matching. In addition, our proprietary technology allows us to produce a high yield of adipose-derived vascular stromal cells (haVSC) from only 30-50mL of adipose tissue, thus minimizing pain and recovery time following the lipoaspiration procedure. This is very significant for China, where patients typically do not have a lot of body fat. The haVSCs are further differentiated and expanded to haMPCs with our proprietary cell culture technology."

About the Therapy
Cellular Biomedicine Group's therapy for KOA is an interventional therapy that consists of 30-50mL of adipose tissue obtained via lipoaspiration from the patient, from which the patient's haMPCs are then expanded using CBMG's proprietary technology. After three weeks there is an initial injection into the knee joints and a second injection three weeks later.

About Cellular Biomedicine Group
Cellular Biomedicine Group, Inc. develops proprietary cell therapies for the treatment of certain degenerative diseases and cancers.  Our developmental stem cell, progenitor cell, and immune cell projects are the result of research and development by scientists and doctors from China and the United States. Our flagship GMP facility, consisting of eight independent cell production lines, is designed, certified and managed according to U.S. standards. To learn more about CBMG, please visit: www.cellbiomedgroup.com

Forward-Looking Statements
Statements in this press release relating to plans, strategies, trends, specific activities or investments, and other statements that are not descriptions of historical facts may be forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Forward-looking information is inherently subject to risks and uncertainties, and actual results could differ materially from those currently anticipated due to a number of factors, which include, but are not limited to, risk factors inherent in doing business. Forward-looking statements may be identified by terms such as "may," "will," "expects," "plans," "intends," "estimates," "potential," or "continue," or similar terms or the negative of these terms. Although CBMG believes the expectations reflected in the forward-looking statements are reasonable, they cannot guarantee that future results, levels of activity, performance or achievements will be obtained. CBMG does not have any obligation to update these forward-looking statements other than as required by law.

Contact:

Jeff Ramson 
Investor Relations
ProActive Capital Group
+1 646 863 6341
Jramson@proactivecapital.com

Sarah Kelly 
Director of Corporate Communications, CBMG
+1 650 566 5064
sarah.kelly@CellBioMedGroup.com


'/>"/>
SOURCE Cellular Biomedicine Group
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Cellular Dynamics Launches MyCell™ Services
2. Life Technologies and Cellular Dynamics International Partner for Global Commercialization of Novel Stem Cell Technologies
3. CeeTox and Cellular Dynamics Collaborate to Offer Predictive In Vitro Test for Cardiotoxicity Using Human iPSC-derived Cells
4. EastBridge Investment Group Announces Merger with Cellular Biomedicine Group
5. The Treatment Landscape for Hepatocellular Carcinoma Will Change Dramatically Over the Next Ten Years Due to the Launch of New Therapies in the United States and EU5
6. Arteriocyte Receives FDA Approval to Initiate Cellular Therapy Trial for Treatment of Thermal Burn Wounds in Wounded Warriors
7. Intra-Cellular Therapies Announces Completion of Phase I Single Rising Dose Trial of First-in-Class Selective Phosphodiesterase 1 (PDE1) Inhibitor and Reports Top-line Safety and Pharmacokinetic Findings
8. Cellular Dynamics Announces Presentations at the Society of Toxicologys 52nd Annual Meeting Demonstrating the Expanding Impact of iPSC-Derived Human Cells on Toxicology Assay Development
9. Cellular Biomedicine Group Marks the Launch of China Clinical Trial for TC-DC Therapy for Hepatocellular Carcinoma
10. Cellular Dynamics International Opens Facility in California, Leasing Space from the Buck Institute to Derive and Bank Human Induced Pluripotent Stem Cells
11. Exosome Diagnostics Presents Data Demonstrating Clinical Applications of Exosome Technology in Brain Cancer, Prostate Cancer, and Alzheimers Disease at the International Society for Extracellular Vesicles 2013 Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... , Feb. 8, 2016  Avista Pharma Solutions ... Eric Setzer as Chief Financial Officer (CFO). Mr. Setzer ... years of experience in various roles within growing technology ... he served as the Executive Director of Finance at ... Raleigh, NC . Previously, Mr. Setzer ...
(Date:2/8/2016)... , Feb. 8, 2016 Vestagen Technical ... high performance apparel for healthcare and other demanding applications, ... Chief Executive Officer. He replaces Dale Pfost , ... Chairman. Mr. Bold is also joining Vestagen,s Board of ... new class of active barrier technologies that combines fluid ...
(Date:2/8/2016)... -- Astellas Pharma Inc. President and Chief Executive Officer Yoshihiko ... as president, Americas Operations, for Astellas US LLC, with ... South America , effective April 1, 2016.  Robinson previously ... in the United States -- a ... , who is retiring in June 2016.  --> ...
Breaking Medicine Technology:
(Date:2/8/2016)... ... February 08, 2016 , ... Remember the old saying “rub some dirt ... Perry A~, author of “Calcium Bentonite Clay” the health benefits of integrating clay into ... detoxifying the body. , A former motivational speaker, Perry A~ has since dedicated her ...
(Date:2/8/2016)... ... 2016 , ... The Association of Home Care Coding & ... Health and Hospice ICD-10 Transition Workgroup are working closely with the American Hospital ... to address concerns over the use of 'A' as the seventh character indicating ...
(Date:2/8/2016)... ... February 08, 2016 , ... ... four states in the U.S. require dental technicians to be certified or obtain ... dental industry, NADL created the “What’s In Your Mouth?” campaign to inform dentists ...
(Date:2/6/2016)... ... February 06, 2016 , ... ... NURSES EXPECTED AT AORN SURGICAL CONFERENCE & EXPO , WHAT:     , This ... an estimated 5000 perioperative nurses in attendance to study the latest evidence-based ...
(Date:2/5/2016)... ... ... Steven Tonkinson, 36, of Coconut Grove, Florida, ran the Miami Marathon on January ... year, he ran all 26.2 miles with a green 25-pound ShelterBox strapped to his ... This Sunday, while many are watching the Superbowl, Steven Tonkinson will strap on the ...
Breaking Medicine News(10 mins):