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Celldex Therapeutics Announces Orphan Drug Designation for CDX-110, a Novel EGFRvIII Vaccine for Glioblastoma Multiforme
Date:12/7/2007

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About Orphan Drug Designation

Orphan drug designation grants special status to promising new therapies that treat rare diseases or conditions affecting fewer than 200,000 people in the United States and entitles seven years of market exclusivity. Additionally, the sponsor of the product is offered incentives which include eligibility for research grants, certain tax benefits, protocol assistance and possible exemptions or reductions of certain regulatory fees during development or at a time of market approval.

About Celldex Therapeutics, Inc.

Celldex Therapeutics, Inc. is a biotechnology company focused on developing therapeutic vaccines that target and stimulate the body's immune system for the treatment of cancer, infectious and autoimmune diseases. Celldex has three product candidates already in or about to enter clinical development targeting multiple cancers and Hepatitis B. Four additional product candidates are in preclinical development for cancer and autoimmune disease. Celldex's proprietary technology platform uses fully human monoclonal antibodies administered directly to patients to target and stimulate dendritic cells - key cells within the immune system. The Company is headquartered in Phillipsburg, New Jersey. On October 22, 2007, Celldex and AVANT Immunotherapeutics, Inc. announced that they had signed a definitive merger agreement. The all-stock transaction, approved by both companies' Boards of Directors, will combine Celldex and Avant. Closing of the merger is contingent upon a vote of approval by the current stockholders of AVANT at a special meeting expected to take place in the first quarter 2008. For more information, please visit the website: http://www.celldextherapeutics.com.

Additional Information about the Merger and Where to Find It

This communication contains "forward-looking" statements within the meaning of the Private Securiti
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SOURCE Celldex Therapeutics
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