Navigation Links
Celladon Corporation Announces MYDICAR® Enzyme Replacement Therapy for Advanced Heart Failure Provides Sustained Reduction in Clinical Events in Patients for 18 Months Compared with Placebo

SEATTLE, Wash., May 23, 2011 /PRNewswire/ -- Celladon Corp., a biopharmaceutical company focused on the discovery and development of innovative treatments for cardiovascular diseases, today announced that 18-month data from its Phase 2 CUPID clinical trial of MYDICAR® demonstrated continued improvements in clinical outcomes in advanced heart failure patients treated with the genetically-targeted enzyme replacement therapy.

"We are pleased to present data from the long-term follow-up portion of the CUPID trial with MYDICAR demonstrating reduced hospitalizations and other cardiovascular events at 18 months after treatment," said Krisztina Zsebo, Ph.D., CEO and President of Celladon, who presented the study's long-term follow-up results during the American Society of Cell and Gene Therapy 2011.

The study of 39 patients met its primary safety and efficacy endpoints at 6 months for high dose MYDICAR versus placebo.  Additionally, after 12 months of receiving a single infusion of MYDICAR, patients treated with the highest dose versus placebo had an 88 percent risk reduction (Hazard Ratio = 0.12, P=0.003), of major cardiovascular events such as:

  • Death
  • Need for left ventricular assist device (LVAD) or cardiac transplant
  • Episodes of worsening of heart failure

Additionally, the 18-month CUPID data from long-term follow-up demonstrate a durable benefit in preventing major cardiovascular events.

The 12 month data presented in 2010 showed that heart failure, which is a progressive disease, became stabilized in high dose MYDICAR-treated patients: heart failure symptoms, exercise tolerance, serum biomarkers and cardiac function essentially improved or remained stable while these parameters deteriorated substantially in patients treated with placebo and concurrent optimal drug and device therapy.

We believe the efficacy sustained in patients over a 18-month period strongly support the continued development of MYDICAR for a Phase 3 study and commercialization," said Roger Hajjar, M.D., Director, Cardiovascular Research Center, Mount Sinai School of Medicine, NY, and  co-founder of Celladon. "The clinical deterioration seen in the placebo patients receiving ongoing optimal standard therapy emphasizes the tremendous unmet medical need in people with advanced heart failure. Based on these results we are encouraged that MYDICAR can fill this need."  

The CUPID Trial

The CUPID trial (Calcium Up-regulation by Percutaneous administration of gene therapy In cardiac Disease) is a randomized, double-blind, placebo-controlled study to assess the efficacy and safety of MYDICAR®, a genetically targeted enzyme replacement therapy for advanced heart failure. Enrolled patients had severe forms of the disease defined by New York Heart Association Class III or IV heart failure, significantly impaired pumping function of their hearts (ejection fraction ≤ 35 percent), and less than half the normal ability to transport and utilize oxygen during exercise testing (VO2max ≤20 mL/kg/min). The CUPID trial Identifier is NCT00454818.

Primary outcome measures included safety, worsening of heart failure leading to hospitalization, frequency of and time to cardiac transplantation or LVAD implantation, changes in patients' ability to exercise, echocardiographic assessments, a blood test for NT-proBNP, and symptoms of heart failure.


MYDICAR® is a genetically targeted enzyme replacement therapy intended to restore levels of SERCA2a, a regulator of calcium cycling and contractility. SERCA2a levels decline in all forms of late-stage heart failure resulting in deficient heart function. With MYDICAR®, the SERCA2a gene is delivered using a recombinant adeno-associated virus (AAV) as the vector. AAV is a naturally occurring virus not associated with any disease in humans. MYDICAR® is delivered in a single dose directly to the heart muscle during a routine outpatient cardiac catheterization procedure, similar to an angiogram. MYDICAR® is synergistic and additive across current heart failure treatments such as ACE inhibitors, beta-blockers, sprinolactone/diuretics, and biventricular pacing devices. No treatment substitution decision is required by the treating physician.

About Heart Failure

Chronic heart failure is a leading cause of hospitalization and is expected to result in direct and indirect costs of $39.2 billion to the U.S. healthcare system in 2010. Nearly 6 million people in the U.S. have heart failure, and at least 670,000 new cases will be diagnosed this year. Heart failure leads to about 280,000 deaths annually. The most common symptoms of heart failure are shortness of breath, feeling tired and swelling in the ankles, feet, legs and sometimes the abdomen. There is no cure.

About Celladon

Celladon Corp., based in La Jolla, Calif., was launched in October 2004 as a privately held biotechnology company with the goal of becoming the leader in developing molecular therapies for the treatment of heart failure. The company's products target calcium cycling and contractility deficit in heart muscle cells. In addition to MYDICAR®, Celladon is developing traditional small molecule activators of SERCA2a for the treatment of heart failure. To learn more about Celladon, visit Celladon's Web site at

SOURCE Celladon Corporation
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Celladon Provides MYDICAR(R) Program Update of First-In-Human Trial for Advanced Heart Failure at American Society of Gene Therapy Annual Meeting
2. Celladon Corporation Announces Presentation of First-in-Human Gene Transfer to Treat Heart Failure at the 12th Annual Meeting of the American Society of Gene Therapy
3. Celladon Announces Presentation of Clinical Data From First-in-Human MYDICAR(R) Trial for Advanced Heart Failure at American Heart Association Scientific Sessions
4. Gumz to Retire as President and CEO of Olympus Corporation of the Americas
5. Medication Delivery Innovator Baxa Corporation Offers Best Practices for Administering Over-the-Counter Liquid Medicine to Babies and Toddlers
6. Families of Spinal Muscular Atrophy Announces Repligen Corporation Receives FDA Approval to Begin Phase I Clinical Trial in SMA
7. TechPrecision Corporation Receives $1.6 Million in New Orders from Existing Customers
8. SenSage Named Cerner Corporations Accelerate Partner of the Year
9. Boston Scientific Announces Favorable Jury Verdict Against Cordis Corporation in Stent Patent Litigation
10. Henry Schein Ranks #317 in 2011 Fortune 500 Ranking of Americas Largest Corporations
11. Omeros Corporation Reports First Quarter 2011 Financial Results
Post Your Comments:
(Date:10/12/2015)... Paul, Minn. , Oct. 12, 2015 ... it, a need to help integrate these devices into ... leader of ergonomic healthcare mounting and mobility solutions, has ... its lightest cart yet, for a wide array of ... S-Tablet Cart SV10 was developed exclusively for Microsoft Surface ...
(Date:10/12/2015)... , Oct. 12, 2015  Today, Divurgent is honored ... Advisory Services. As a former CIO, Paul brings 15 years ... just understand or sympathize with today,s CIOs, he is one. ... same challenges Paul has faced, and his new role with ... ensuring technology efficiencies across an organization. ...
(Date:10/12/2015)... , Oct. 12, 2015   Royal Philips ... digitization of pathology, today announced a collaboration with ... world leading provider of genomic-based diagnostic tests, to leverage ... up of its molecular diagnostic testing processes.    ... the examination of patient tissue samples and plays a ...
Breaking Medicine Technology:
(Date:10/13/2015)... ... October 13, 2015 , ... ActivePDF, a leading provider of ... to batch conversions of CAD drawings, plans, and diagrams to PDF that ... eliminates the complexity requirement of specialized applications to view CAD designs. Converting to ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... world’s first commercially-available next-generation sequencing laboratory test for bacterial vaginosis- a significant ... Obstetrics in Vancouver, BC, Canada. , In a presentation entitled: "The ...
(Date:10/12/2015)... , ... October 13, 2015 , ... ... its biannual Heroes in Recovery Awards at Foundations Recovery Network’s Moments of Change ... presented the one-of-a-kind awards to Noah Levine and Dean Dauphinais who exemplify the ...
(Date:10/12/2015)... ... ... article published October 6th by the Herald Tribune, a recent study that compared ... 1988 has shown that it really is more difficult to lose weight these days. Specifically, ... 1971 would be on average 10 pounds heavier than their past counterpart. In terms of ...
(Date:10/12/2015)... ... ... Amerec , a leader in the steam and sauna industry, and ... displaying custom sauna and steam room solutions at the ISPA Conference & Expo in ... SpaEquip is recognized for their ability to assist in the design and implementation of ...
Breaking Medicine News(10 mins):