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CellCept(R) and a Reduced Level of CNI Shows Trend Towards Preservation of Kidney Function Versus a Standard-Dose CNI
Date:6/4/2008

e monitored for

neutropenia. If neutropenia develops (ANC < 1.3 x 10cubed/microL),

dosing with CellCept should be interrupted or the dose reduced,

appropriate diagnostic tests performed, and the patient managed

appropriately (see DOSAGE AND ADMINISTRATION).

-- Gastrointestinal bleeding (requiring hospitalization) has been observed

in approximately 3% of renal, in 1.7% of cardiac, and in 5.4% of

hepatic transplant patients treated with CellCept 3 g daily.

-- Common adverse events that were reported in greater than or equal to

20% of patients in CellCept group in controlled studies in prevention

of renal, cardiac or hepatic allograft rejection are listed in Table 8

of the ADVERSE REACTIONS section of the complete Prescribing

Information.

About Roche

Hoffmann-La Roche Inc. (Roche), based in Nutley, N.J., is the U.S. pharmaceuticals headquarters of the Roche Group, one of the world's leading research-oriented healthcare groups with core businesses in pharmaceuticals and diagnostics. For more than 100 years in the U.S., Roche has been committed to developing innovative products and services that address prevention, diagnosis and treatment of diseases, thus enhancing people's health and quality of life. An employer of choice, in 2007 Roche was named Top Company of the Year by Med Ad News, one of the Top 20 Employers (Science) and ranked the No. 1 Company to Sell For (Selling Power). In previous years, Roche has been named as a Top Company for Older Workers (AARP) and one of the Best Companies to Work For in America (Fortune). For additional information about the U.S. pharmaceuticals business, visit our website http://www.rocheusa.com. Product and treatment information for U.S. healthcare professionals is available at http://www.RocheExchange.com.

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