Navigation Links
CellCept(R) and a Reduced Level of CNI Shows Trend Towards Preservation of Kidney Function Versus a Standard-Dose CNI
Date:6/4/2008

(BPAR, graft loss, and death) and mean percent change in calculated glomerular filtration rate (GFR; Nankivell equation) at 12 months. Safety endpoints were incidences of adverse events and serious adverse events. Non-inferiority for treatment failure was tested. Baseline characteristics did not differ among treatment groups with living donors accounting for approximately 50 percent of grafts. Eighty-two percent received tacrolimus (Tac) and 18 percent cyclosporine (CyA). CNI doses and levels were significantly lower in the reduced level of CNI. CellCept doses were greater in CyA-treated subjects in all groups.

Study Results

After 12 months, treatment failure resulted in 20.6 percent (50/243) in the concentration-controlled CellCept and a reduced level of CNI group, compared to 28.7 percent (68/237) in the concentration-controlled CellCept and the standard level of CNI group, and 26.7 percent (64/240) in the fixed-dose of CellCept and the standard level CNI group.

Five patients (2.1 percent) in the concentration-controlled CellCept and a reduced level of CNI group died; two patients (0.8 percent) died in the concentration-controlled CellCept and the standard level of CNI group; and five patients (2.1 percent) died in the fixed-dose of CellCept and the standard level CNI group.

Groups Patients Graft Loss BPAR Lost to f/u

MMFcc/CNIrl 243 5 (2.1%) 15 (6.2%) 25 (10.3%)

MMFcc/CNIsl 237 4 (1.7%) 23 (9.7%) 23 (9.6%)

MMFfd/CNIrl 240 4 (1.7%) 23 (9.6%) 32 (13.3%)

Note: events are mutually exclusive because only first event counted/patient

Serum creatinine tended to lower at 12 months in the Tac versus CyA treated patients and in the concentration-controlled CellCept and reduced level of CNI group (p=0.08). The stability of renal function over time was greatest in this group as well. Despite higher CellCept doses in the conc
'/>"/>

SOURCE Roche
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Final Results of the CellCept(R) Spare the Nephron (STN) Study Show Maintenance Therapy is Associated with Improved Renal Function
2. Data Show Rufinamide, an Investigational Adjunctive Treatment for Lennox- Gastaut Syndrome, Reduced Drop Attacks by More Than 40%
3. Pivotal Study Shows Physician/Nurse Teams Using SEDASYS(TM) System Reduced Risk of Over Sedation With Propofol
4. Data Presented at AAN Show That Lacosamide Significantly Reduced Pain and was Generally Well Tolerated in Patients With Diabetic Neuropathic Pain
5. Medivations Dimebon(TM) Significantly Improved Daily Function in Alzheimers Disease Patients, Resulting in Reduced Need for Caregiver Assistance
6. Lotrel, a Single-Pill Combination for Treating High Blood Pressure, Reduced Cardiovascular Events by 20% in High-Risk Patients
7. Reduced Lung Capacity Accelerates With Diabetes
8. Perioperative Eloxatin(R)-Based Regimen Significantly Reduced the Risk of Relapse Versus Surgery Alone in Eligible Colorectal Cancer Patients with Initially Resectable Liver Metastases
9. Medivations Dimebon(TM) Stabilizes Behavioral Symptoms in Alzheimers Disease Patients, Resulting in Reduced Caregiver Distress
10. Breast Cancer Treatment Is Reduced to One Week
11. Study Shows That Low-Molecular Weight Heparin (LMWH) was Associated with Reduced Hospital Costs of Venous Thromboembolism (VTE) Treatment Compared with Unfractionated Heparin (UFH)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)...  Neuraltus Pharmaceuticals, Inc. announced today that promising efficacy ... NP001 for the treatment of amyotrophic lateral sclerosis (ALS, ... today in an oral presentation at the inaugural ... in Bloomington, Minnesota , September 17-19, ... a high dose of NP001 (2mg/kg) was associated with ...
(Date:9/17/2014)... , Sept. 17 2014 IBM (NYSE: ... is using IBM technical computing and storage technology ... cancer patients. These services deliver critically important information ... each patient,s unique cancer, which could lead to ... healthcare system in general. Today, optimal ...
(Date:9/17/2014)... Switzerland , September 17, 2014 /PRNewswire/ ... , is proud to congratulate Biocartis commitment in ... Diagnostics is a long-time investor in Biocartis as ... ™ Biocartis, fully automated, real-time PCR based ... fast and easy access to clinical molecular diagnostic ...
Breaking Medicine Technology:Neuraltus Pharmaceuticals' ALS Treatment Candidate, NP001, Highlighted at ALS Research Group Summit 2Neuraltus Pharmaceuticals' ALS Treatment Candidate, NP001, Highlighted at ALS Research Group Summit 3Caris Life Sciences Selects IBM to Accelerate Use of Molecular Profiling in Cancer Treatment Selection 2Caris Life Sciences Selects IBM to Accelerate Use of Molecular Profiling in Cancer Treatment Selection 3Caris Life Sciences Selects IBM to Accelerate Use of Molecular Profiling in Cancer Treatment Selection 4Debiopharm Diagnostics Portfolio Company Biocartis Ships its First Idylla Instrument 2
... N.J. , March 11 Bayer HealthCare ... been granted by the U.S. Food and Drug Administration ... of pulmonary infection due to Pseudomonas aeruginosa in cystic ... granted by the European Medicines Agency. Ciprofloxacin DPI is ...
... DETROIT , March 11 Caraco Pharmaceutical ... oxaliplatin injections. These 50mg and 100mg oxaliplatin injections, which ... from the US Food and Drug Administration (FDA) for ... an anticancer used in the treatment of colon and ...
Cached Medicine Technology:FDA Grants Bayer HealthCare Pharmaceuticals Orphan Drug Designation for Investigational Ciprofloxacin Dry Powder Inhaler for the Treatment of Cystic Fibrosis 2FDA Grants Bayer HealthCare Pharmaceuticals Orphan Drug Designation for Investigational Ciprofloxacin Dry Powder Inhaler for the Treatment of Cystic Fibrosis 3FDA Grants Bayer HealthCare Pharmaceuticals Orphan Drug Designation for Investigational Ciprofloxacin Dry Powder Inhaler for the Treatment of Cystic Fibrosis 4FDA Grants Bayer HealthCare Pharmaceuticals Orphan Drug Designation for Investigational Ciprofloxacin Dry Powder Inhaler for the Treatment of Cystic Fibrosis 5FDA Grants Bayer HealthCare Pharmaceuticals Orphan Drug Designation for Investigational Ciprofloxacin Dry Powder Inhaler for the Treatment of Cystic Fibrosis 6FDA Grants Bayer HealthCare Pharmaceuticals Orphan Drug Designation for Investigational Ciprofloxacin Dry Powder Inhaler for the Treatment of Cystic Fibrosis 7FDA Grants Bayer HealthCare Pharmaceuticals Orphan Drug Designation for Investigational Ciprofloxacin Dry Powder Inhaler for the Treatment of Cystic Fibrosis 8Caraco Pharmaceutical Laboratories, Ltd. Markets Generic Eloxatin(R) 2Caraco Pharmaceutical Laboratories, Ltd. Markets Generic Eloxatin(R) 3
(Date:9/17/2014)... September 17, 2014 Kristen Yarker, MSc, RD ... parents of children 9 months to 2 years old who ... furthermore, prevent picky eaters from developing by encouraging healthy eating ... (9 months to 2 years): How to Transition From Baby ... Is Getting the Nutrition They Need)” is a new online ...
(Date:9/17/2014)... Diego, Calif. (PRWEB) September 17, 2014 ... Nature’s monthly interruptions, giving girls of all ages ... a wellness company founded by women, for women, ... Girl Uninterrupted® (http://GirlU.com) to relieve the ... cramps, bloating and irritability. , As a ...
(Date:9/17/2014)... A raucous childhood in an Italian-Polish ... form author Nancy Chovancek’s laughter-filled new book, “Angry Birds ... of short stories that prove the best way to ... positive message of empowerment and resilience, everyone can identify ... author with two books under her belt on the ...
(Date:9/17/2014)... Seattle, Wa (PRWEB) September 17, 2014 ... published by the Telegraph in August 2014, scientists made ... cure for diabetes, but still failed. The article indicates ... , Despite this existing fact, there are many forward-thinking ... for diabetes treatment in a natural way. Dr. Kenneth ...
(Date:9/17/2014)... In honor of National Health IT Week Sept. ... professionals for gaining a competitive edge in the healthcare ... demand for qualified health IT professionals are at an ... differentiating factor when filling a position. The skill most ... clinical workflow and terminology experience. American Sentinel offers ...
Breaking Medicine News(10 mins):Health News:Nutritionist Kristen Yarker Offers Parents a Fresh Approach to Prevent Picky Eaters in New Online Seminar 2Health News:Nutritionist Kristen Yarker Offers Parents a Fresh Approach to Prevent Picky Eaters in New Online Seminar 3Health News:Girl Uninterrupted® Debuts New Look for All-Natural, PMS-Relief Supplement, Launching Today 2Health News:Girl Uninterrupted® Debuts New Look for All-Natural, PMS-Relief Supplement, Launching Today 3Health News:Girl Uninterrupted® Debuts New Look for All-Natural, PMS-Relief Supplement, Launching Today 4Health News:Discover a Safe and Effective Treatment for Diabetes with The Diabetes Protocol – Vinamy 2Health News:American Sentinel University Offers Tips to Health IT Professionals for Gaining Competitive Edge in the Job Market 2Health News:American Sentinel University Offers Tips to Health IT Professionals for Gaining Competitive Edge in the Job Market 3Health News:American Sentinel University Offers Tips to Health IT Professionals for Gaining Competitive Edge in the Job Market 4
... A protein abundantly found in treatment-resistant cancers holds an ... would normally detect DNA damage and force defective cells ... the current Cancer Cell . "Overexpression ... resistance to DNA-damaging chemotherapy, but we haven,t known how ...
... , SUNDAY, Feb. 26 (HealthDay News) -- Researchers report that ... mature into eggs that may be capable of fertilization. ... potentially lead to new reproductive technologies and possibly extend the ... that women were born with a lifetime supply of eggs, ...
... (HealthDay News) -- A potentially dangerous heart rhythm problem called ... decline in older people at risk for heart disease, new ... the Canadian Medical Association Journal , researchers analyzed data ... countries, aged 55 and older. All of the participants had ...
... lives and may save money. There are two very commonly ... it is unclear which is the most effective and provides ... BY-BAND study led by the University of Bristol and funded ... (NIHR HTA) programme will compare the outcomes of stomach bypass ...
... a new treatment for type 2 diabetes, improves blood sugar ... significantly lower risk of creating a dangerous drop in blood ... results of the phase 2 randomized trial were published Online ... diabetes is the most common form of diabetes accounting for ...
... An experimental drug improves patients, blood sugar control without ... with type 2 diabetes, according to the results of a ... more prevalent form of the disease, accounting for about 90 ... diabetes involves a gradual decline in how insulin responds to ...
Cached Medicine News:Health News:Aurora-A hinders tumor-suppressor to allow chemotherapy resistance 2Health News:Aurora-A hinders tumor-suppressor to allow chemotherapy resistance 3Health News:Stem Cell Finding Could Expand Women's Lifetime Supply of Eggs 2Health News:Stem Cell Finding Could Expand Women's Lifetime Supply of Eggs 3Health News:Irregular Heartbeat May Predict Mental Decline in Some 2Health News:Which type of obesity surgery is best? 2Health News:Diabetes drug gets patients with Type 2 diabetes on target 2Health News:Experimental Drug Shows Promise Against Type 2 Diabetes 2Health News:Experimental Drug Shows Promise Against Type 2 Diabetes 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: