Navigation Links
CellCentric Licenses Novel Epigenetic Discovery Programme to Takeda
Date:2/23/2010

CAMBRIDGE, England, February 23, 2010 /PRNewswire/ -- From its broad portfolio of novel targets in epigenetics, CellCentric has out-licensed exclusively the development and commercialisation of an important programme focused on cancer.

Under the terms of the new agreement, CellCentric will receive from Takeda Pharmaceutical Company Limited an upfront payment and pre-clinical and clinical milestones, in addition to royalties. Based on the royalties and milestones defined, the overall deal could be worth in excess of $200m to CellCentric over the course of the agreement.

This is a pioneering deal for the emerging area of epigenetics, demonstrating the commercial interest in novel epigenetic targets beyond HDACs (histone deacetylases) and DNMTs (DNA methyltransferases ). Therapeutic research will be initiated by Takeda's Research Group. Development of molecules stemming from this agreement will be completed by Millennium: The Takeda Oncology Company, which is responsible for Takeda's global oncology development strategy.

Many diseases including cancer involve a loss of cell fate control. In many cases this is associated with aberrant epigenetic changes to chromatin: dynamic modifications of DNA and its associated proteins, including histones. These epigenetic alterations are caused by a range of enzymes. Initial therapeutic interest has been focused on inhibiting HDAC and DNMTs. It has become increasingly clear that there are many other key epigenetic related enzymes that can be targeted and which may offer greater specificity of action. These include histone methyltransferases, demethylases and ubiquitin-related enzymes.

CellCentric has an innovation platform built upon relationships with over 30 world leading research labs in epigenetics. The company has identified and prioritised multiple next generation targets and runs a series of active drug discovery programmes from its centre in Cambridge, UK. As programmes move forward, CellCentric is able to gain continued benefit and support from multiple Principal Investigators within its network.

With an extensive portfolio and rich pipeline, CellCentric's strategy is to develop some target programmes through licences and collaborations with Pharmaceutical companies while retaining other programmes for development itself.

Dr Hiroyuki Odaka, General Manager of the Pharmaceutical Research Division of Takeda said "Epigenetics is an important area for novel oncology therapeutics. This new agreement demonstrates our commitment to researching and pioneering the best ways to treat cancer."

Dr Will West, CEO of CellCentric added "This licence is a strong endorsement of the way we are approaching innovation in epigenetics. This is an area that is no longer seen as just interesting, but as a necessity for pharmaceutical companies growing their armoury for tackling intractable diseases such as cancer".

Notes:

CellCentric is a biotechnology company focused on epigenetics. Formed in 2004, it works with over 30 academic labs worldwide to identify, patent and commercialise product opportunities. CellCentric currently has 7 novel target discovery programmes ongoing, focused on cancer, as well as multiple projects related to reprogramming and epigenetic tools. For further details on the company, see: http://www.cellcentric.com.

Located in Osaka, Japan, Takeda is a research-based global company with its main focus on pharmaceuticals. As the largest pharmaceutical company in Japan and one of the global leaders of the industry, Takeda is committed to striving toward better health for individuals and progress in medicine by developing superior pharmaceutical products. Additional information about Takeda is available through its corporate website http://www.takeda.com.

SOURCE CellCentric Ltd

Back to top
'/>"/>
SOURCE CellCentric Ltd
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. PSKW & Associates LLC Acquires Triax Media, Licenses Triax to Subsidiary, Centricity Group
2. TenX Biopharma Licenses Zanolimumab From Genmab
3. Omnicare Clinical Research Licenses LiquentConnect to Create Added Value for Clients
4. Raytheon BBN Technologies Licenses Stereo Digital Mammography Technology to FUJIFILM Corporation
5. SCOLR Pharma, Inc. Licenses Dietary Supplements
6. StemCyte Licenses Promising IP for Stem Cell Therapy to Treat Stroke
7. The Quigley Corporation Licenses Naturally Derived Compound For Scar Improvement; License Requires Payments Totaling $1.1 Million To The Quigley Corporation Over A Five Year Period For Exclusive Ownership
8. Access Licenses ProLindac(TM) and MuGard(TM) to JCOM Ltd, an Affiliate of DONG-A Pharmaceuticals in Korea
9. Cerenis Therapeutics In-Licenses Intellectual Property for New Treatment of Aortic Valve Stenosis
10. Neuralstem Licenses Cleveland Clinic Spinal Cord Injection Technology
11. Diakron Licenses Anticoagulant Drug Candidate from Merck & Co., Inc.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2016)... , June 23, 2016 Research and ... Global Market - Forecast to 2022" report to their ... treatment method for the patients with kidney failure, it replaces ... fluid from the patient,s blood and thus the treatment helps ... and chloride in balance. Increasing number of ...
(Date:6/23/2016)... Research and Markets has announced the addition ... Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), Functionality (Filler, Binder, ... Forecast to 2021" report to their offering. ... excipients market is projected to reach USD 8.1 Billion ... forecast period 2016 to 2021. The ...
(Date:6/23/2016)... Roche (SIX: RO, ROG; OTCQX: RHHBY) announced ... BRAHMS PCT (procalcitonin) assay as a dedicated testing solution ... this clearance, Roche is the first IVD company in ... sepsis risk assessment and management. PCT is ... levels in blood can aid clinicians in assessing the ...
Breaking Medicine Technology:
(Date:6/26/2016)... ... ... legally blind and certified personal trainer is helping to develop a weight loss fitness plan ... fix the two major problems leading the fitness industry today:, , ... They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... TX (PRWEB) , ... June 25, 2016 , ... Austin ... of the American College of Mohs Surgery and to Dr. Russell Peckham for medical ... and highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery ...
(Date:6/25/2016)... ... 25, 2016 , ... First Choice Emergency Room , the largest network ... the Medical Director of its new Mesquite-Samuell Farm facility. , “We are pleased ... location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van ... Wellness at Work award to iHire in recognition of their exemplary accomplishments in worksite ... 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Those who ... with these feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, ... Marne, Michigan, has released tools for healthy coping following a traumatic event. , Trauma ...
Breaking Medicine News(10 mins):