Navigation Links
Cell Therapeutics Resubmits Pixantrone NDA to FDA for Consideration of Accelerated Approval
Date:10/24/2011

TI an FDA action date by April 2012.

Pixantrone is also under review for approval in Europe. The Company expects to receive its day 180 responses from the European Medicines Agency (the "EMA") in this quarter.

About Pixantrone

Pixantrone is a novel aza-anthracenedione that has distinct structural and physio-chemical properties that make its anti-tumor activity unique in this class of agents. Similar to anthracyclines, pixantrone inhibits Topo-isomerase II but unlike anthracyclines -- rather than intercalation with DNA -- pixantrone alkylates DNA -- forming stable DNA adducts with particular specificity for CpG-rich, hyper-methylated sites. These structural differences resulted in significantly enhanced anti-lymphoma activity compared to doxorubicin in preclinical models. In addition, the structural motifs on anthracycline-like agents that are responsible for the generation of oxygen free radicals and the formation of toxic drug-metal complexes have also been modified in pixantrone in an effort to prevent the binding of iron and perpetuation of superoxide production -- both of which are the putative mechanism for anthracycline induced acute cardiotoxicity. These novel pharmacologic differences may allow re-introduction of anthracycline-like potency in the treatment of relapsed/refractory diffuse large lymphoma without unacceptable rates of cardiotoxicity.

About Cell Therapeutics, Inc.

Headquartered in Seattle, CTI is a biopharmaceutical company committed to developing an integrated portfolio of oncology products aimed at making cancer more treatable. For additional information, please visit www.CellTherapeutics.com http://www.CellTherapeutics.com.

Sign up for email alerts and get RSS feeds at our Web site, http://www.CellTherapeutics.com/investors_alert

'/>"/>
SOURCE Cell Therapeutics, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Halozyme Therapeutics to Present Data on PEGPH20 at the Upcoming 2011 EORTC-NCI-ASCO Annual Meeting
2. Cell Therapeutics, Inc. (CTI) to Present at 10th Annual BIO Investor Forum
3. Nile Therapeutics Completes Dosing of Clinical Trial Evaluating the Subcutaneous Infusion of Cenderitide in Chronic Heart Failure Patients
4. Depression Therapeutics - Pipeline Assessment and Market Forecasts to 2018
5. Karyopharm Therapeutics Inc. and Katholieke Universiteit Leuven Sign Exclusive Collaboration for the Discovery of Novel CRM1/Exportin 1 Inhibitors
6. Echo Therapeutics Hires Product Development Management Executive
7. Prime Therapeutics Demonstrates Willingness to Show Actual Pharmacy Costs
8. Echo Therapeutics Announces Positive Results of Clinical Trial of Its Symphony® Continuous Glucose Monitoring System
9. Womens Health Therapeutics, Analysis and Market Forecasts to 2016 - High Unmet Need will Drive the Uptake of Novel Drugs in the Menopause and Osteoporosis Markets
10. Metabolic Disorders Therapeutics Market to 2017 - Patent Expiry of Lipitor in 2011 will Negatively Impact Dyslipidemia Market Value
11. Argos Therapeutics Late Scientific Co-founder Ralph Steinman, M.D., Awarded Nobel Prize in Medicine for Discovery of Dendritic Cells as Critical Sentinels of Immune System
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/26/2014)... DALLAS , November 25, 2014 ... Surgical Instruments Market by Power Source (Electric, Battery, ... Console, Cables, Blade, Burr, Cart), by Application (Orthopedic, ... 2019" published by MarketsandMarkets, the global Powered Surgical Instruments ... to $1.6 Billion in 2014 and is expected ...
(Date:11/26/2014)... SAN FRANCISCO , Nov. 25, 2014  goBalto, ... solutions, has been recognized as a winner of Red ... received a Global Top 100 North America award in ... the international technology landscape. Red Herring,s Top ... for identifying promising new companies and entrepreneurs. Red Herring ...
(Date:11/26/2014)... Nov. 25, 2014  Medtronic,s roughly $43 ... been widely discussed in the media for its ... a stronger leading player in one of the ... The healthcare market research firm said  the two ... a diverse set of solutions spanning inpatient to ...
Breaking Medicine Technology:Powered Surgical Instruments Market Worth $2.1 Billion by 2019 2Powered Surgical Instruments Market Worth $2.1 Billion by 2019 3Powered Surgical Instruments Market Worth $2.1 Billion by 2019 4goBalto Selected as a 2014 Red Herring Top 100 Global Company 2goBalto Selected as a 2014 Red Herring Top 100 Global Company 3Medtronic - Covidien: Beyond Taxes, Deal Will Create Patient Monitoring Power, according to Kalorama Information 2Medtronic - Covidien: Beyond Taxes, Deal Will Create Patient Monitoring Power, according to Kalorama Information 3
... Kinetics, Inc. (NKI) ( www.neuro-kinetics.com ), manufacturers of ... neuro-otologic, vestibular and neurological testing, said today that ... control and analysis software. Clinical specialists ... conduct vestibular, oculomotor and optokinetic tests to detect ...
... of Wolters Kluwer Health and ... for the medical, scientific, and academic markets, is pleased to announce ... the first clinical tool from Ovid designed especially for physicians ... on relevant full-text content from Ovid. It,s the only solution that ...
Cached Medicine Technology:Neuro Kinetics Releases Updated Version of Neuro-Otologic Control and Analysis Software 2Ovid Announces its First Clinical Tool, OvidMD, Designed for Physicians and Other Clinicians 2Ovid Announces its First Clinical Tool, OvidMD, Designed for Physicians and Other Clinicians 3Ovid Announces its First Clinical Tool, OvidMD, Designed for Physicians and Other Clinicians 4
(Date:11/28/2014)... Agein.com, the Internet’s premier anti-aging web site ... the foremost experts in the industry, is releasing its top ... winter. , “The official start of winter is still three ... hit with an icy blast. After one of the worst ... will usher in another brutal winter,” says Dr. Kevin J. ...
(Date:11/28/2014)... York, NY (PRWEB) November 28, 2014 ... Salvage ( http://www.rustysautosalvage.com ), one of the nation's leading ... junk and salvage vehicles to be more competitive and ... customer’s lives during this festive time of year. , ... many car owners across the US also deal with ...
(Date:11/28/2014)... (PRWEB) November 28, 2014 On Monday, ... and Sendik’s will present Feeding America Eastern Wisconsin with ... Food Market to donate a portion of proceeds to ... Sendik’s promotion, “7 Days, 7 Ways to Save” with ... Fyffes pineapples were two for $4 and Turbana bananas ...
(Date:11/28/2014)... Miami, FL (PRWEB) November 28, 2014 ... contemporary, responsive website. Practice founder Dr. Jeffrey ... site. Created using a groundbreaking WordPress platform, the ... devices. , Currently, up to 75% of ... More than ever, these people are logging on with ...
(Date:11/28/2014)... (PRWEB) November 28, 2014 Written and narrated ... Brook Forest Voices releases the “The Happiest Man In ... a compelling account of how and why Project C.U.R.E. came ... by his mother Josie and the Reverend Richard W. Jackson, ... the age of 30, but realized that he wasn’t happy. ...
Breaking Medicine News(10 mins):Health News:Agein Corporation, a Leading Anti-Aging Company, Releases Top Diet and Personal Care Tips for Preventing Dry Skin this Season 2Health News:Rusty's Auto Salvage Increasing Their Cash Offers to Help Drivers Save Throughout the Busy Holiday Season 2Health News:Turbana Partners With Sendik's Food Market to Donate $11,500 to Local Hunger-Relief Non-Profit 2Health News:Turbana Partners With Sendik's Food Market to Donate $11,500 to Local Hunger-Relief Non-Profit 3Health News:Top Rhinoplasty Surgeon Launches Innovative Website 2Health News:Thanksgiving Weekend Audiobook Treat! “The Happiest Man In the World: Life Lessons From a Cultural Economist” by Dr. James W. Jackson 2
... LINDA, Calif., Nov. 5 For any woman ... woman trapped in an abusive relationship,without the confidence ... Spanish-language novel, "Yo Mujer" (published by AuthorHouse --, ... the inspirational story of one woman,s journey to,freedom ...
... and Redwood Shores, CA November 4, 2008 ... Navigenics, Inc. today announced a medical education program ... factors for disease, the current evidence about the ... risk, and promising practices for utilizing those tools ...
... Through the ... ... York Times best-selling author Ellie Krieger, of Food Network,fame, joins Yoplait(R) ... contains live and active probiotic cultures,specifically designed for digestive health and ...
... earnings projection --, LAKE FOREST, Ill., Nov. 5 Hospira, ... company, today reported results for the third quarter of 2008., ... the third quarter of 2008, compared to ... 2007. -- Adjusted* diluted earnings per share increased 28.6 percent ...
... BRANFORD, Conn., Nov. 5 CuraGen Corporation,(Nasdaq: CRGN ... that Dr. Timothy M. Shannon, President and Chief,Executive Officer, ... Renshaw,Annual Global Investment Conference on Wednesday, November 12, 2008, ... at the New York Palace,Hotel in New York, NY., ...
... Californians for SAFE Food, the,statewide coalition endorsing ... to the California family farmers, food safety and ... community,groups who lent their energy, expertise and support ... Yes on 2 campaign, backed by one of ...
Cached Medicine News:Health News:'Yo Mujer': Woman Escapes from Abusive Marriage in New Spanish-Language Novel 2Health News:New program to help physicians understand role of DNA-based preventive medicine 2Health News:Healthy Eating Expert Ellie Krieger Joins Yoplait(R) Yo-Plus(TM) to Raise Awareness of Digestive Health 2Health News:Healthy Eating Expert Ellie Krieger Joins Yoplait(R) Yo-Plus(TM) to Raise Awareness of Digestive Health 3Health News:Hospira Reports Third-Quarter 2008 Results 2Health News:Hospira Reports Third-Quarter 2008 Results 3Health News:Hospira Reports Third-Quarter 2008 Results 4Health News:Hospira Reports Third-Quarter 2008 Results 5Health News:Hospira Reports Third-Quarter 2008 Results 6Health News:Hospira Reports Third-Quarter 2008 Results 7Health News:Hospira Reports Third-Quarter 2008 Results 8Health News:Hospira Reports Third-Quarter 2008 Results 9Health News:Hospira Reports Third-Quarter 2008 Results 10Health News:Hospira Reports Third-Quarter 2008 Results 11Health News:Hospira Reports Third-Quarter 2008 Results 12Health News:Hospira Reports Third-Quarter 2008 Results 13Health News:Hospira Reports Third-Quarter 2008 Results 14Health News:Hospira Reports Third-Quarter 2008 Results 15Health News:Hospira Reports Third-Quarter 2008 Results 16Health News:Hospira Reports Third-Quarter 2008 Results 17Health News:Hospira Reports Third-Quarter 2008 Results 18Health News:Hospira Reports Third-Quarter 2008 Results 19Health News:Hospira Reports Third-Quarter 2008 Results 20Health News:Hospira Reports Third-Quarter 2008 Results 21Health News:Hospira Reports Third-Quarter 2008 Results 22Health News:Hospira Reports Third-Quarter 2008 Results 23Health News:Hospira Reports Third-Quarter 2008 Results 24Health News:Hospira Reports Third-Quarter 2008 Results 25Health News:Hospira Reports Third-Quarter 2008 Results 26Health News:Hospira Reports Third-Quarter 2008 Results 27Health News:Hospira Reports Third-Quarter 2008 Results 28
Bivona® Uncuffed Neonatal and Pediatric Silicone Tracheostomy Tubes....
Fome-Cuf® tubes can breathe with the patient to provide a safe, effective, and low pressure seal throughout the ventilatory cycle....
... flange tracheostomy tubes are intended ... proper length fixed neck flange ... ,Adjustable neck flange Hyperflex™ ... for both horizontal and vertical ...
... Neonatal and Pediatric TRACH ... a multi access catheter ... lavage/irrigation port and locking ... sizes and packaging configurations. ...
Medicine Products: