Navigation Links
Celator(R) Pharmaceuticals Successfully Uses Nanoparticles to Administer Hydrophobic Drug Combinations
Date:4/16/2008

Results presented at American Association for Cancer Research meeting

indicate that technology could improve control in administration of

non-water-soluble drugs to treat cancer and possibly other diseases

PRINCETON, N.J., April 16 /PRNewswire/ -- Celator Pharmaceuticals today reported results on a novel approach designed to deliver drugs that are incapable of dissolving in water (hydrophobic drugs) in nanoparticles to enhance and control drug circulation. These findings allow the company to combine hydrophobic drugs such as paclitaxel with other anti-cancer drugs, based on the company's proprietary CombiPlex technology(TM). The results were presented today in a poster presentation at the American Association for Cancer Research meeting in San Diego.

CombiPlex(TM) is a drug ratio technology platform that represents a new approach which identifies a ratio of drugs that will deliver a synergistic benefit, locks the desired ratio in a drug delivery vehicle, and maintains the ratio in patients with the goal of improving clinical outcomes.

To date, Celator has utilized liposomes to deliver synergistic drug combinations to treat cancer. Hydrophobic drugs such as paclitaxel are not amenable to this form of delivery because they detach from liposomes almost immediately after injection. Celator scientists reported that they were able to generate a library of hydrophobic paclitaxel conjugates incorporated into nanoparticles. In preclinical testing, these nanoparticles were shown to circulate in the blood for more than 24 hours, allowing the drug to accumulate selectively in solid tumors where it can then be released and exposed to the tumor cells.

According to the research findings, the ability to optimize paclitaxel conjugates could make it possible for higher drug levels to be maintained in plasma for extended periods, which is associated with superior preclinical antitumor efficacy when compared to drug delivery involving pacli
'/>"/>

SOURCE Celator Pharmaceuticals
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Celator(R) Pharmaceuticals Reports CPX-351 Shows Anti-Cancer Activity in Leukemia Patients
2. Auxilium Pharmaceuticals, Inc. Receives Clearance to Resume Clinical Trials for XIAFLEX(TM)
3. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
4. Solvay Pharmaceuticals, Inc. and Wyeth Pharmaceuticals Announce Receipt of an FDA Action Letter for Bifeprunox, an Investigational Treatment for Schizophrenia
5. Callisto Pharmaceuticals Opens Additional Sites for Phase II Clinical Trial of Atiprimod in Advanced Carcinoid Cancer Patients
6. WallSt.net (www.wallst.net) Updates the Investment Community Through an All-New Interview With RegeneRx Biopharmaceuticals CEO
7. Quark Pharmaceuticals, Inc. Presented Positive Preclinical Results of Systemic RNAi Compound for Acute Renal Failure (ARF)
8. Peregrine Pharmaceuticals Doses First Patient in Cotara(R) Phase II Brain Cancer Trial In India
9. Nabi Biopharmaceuticals Announces Second Quarter 2007 Financial Results
10. Access Pharmaceuticals Provides Update on Clinical Development Plan of ProLindac
11. Quark Pharmaceuticals Extends Research Agreement with State University of New York for Proprietary siRNA Compounds for Acute Hearing Loss
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)...  Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) will webcast management ... and Regeneron will host an IR Thematic Conference Call on Alirocumab ... 2014 , Baird 2014 Healthcare Conference at 4:05 ... , Citi,s 9 th Annual Biotech Conference at ... , Morgan Stanley Global Healthcare Conference at 8:45 ...
(Date:8/19/2014)... Luoxis Diagnostics, Inc. , a ... MKT: AMPE), today announced an upcoming presentation at ... American Academy of Surgical Trauma (AAST) and Clinical ... Philadelphia, Pennsylvania that will be held ... from a recently completed five-year prospective clinical trial ...
(Date:8/19/2014)... ALBANY, New York , August 19, 2014 /PRNewswire/ ... " Surgical Navigation Systems Market (Neurosurgical Navigation Systems, ... Industry Analysis, Size, Share, Growth, Trends and Forecast, 2014 ... valued at USD 218.5 million in 2013 and is ... 2014 to 2020, to reach an estimated value of ...
Breaking Medicine Technology:Luoxis Announces Presentation of Positive Clinical Findings from Five-Year Clinical Study of Traumatic Brain Injury and Oxidation-Reduction Potential at 2014 American Academy of Surgical Trauma Meeting 2Luoxis Announces Presentation of Positive Clinical Findings from Five-Year Clinical Study of Traumatic Brain Injury and Oxidation-Reduction Potential at 2014 American Academy of Surgical Trauma Meeting 3Global Surgical Navigation Systems Market to Reach USD 295.5 Million in 2020 - Report by MarketResearchReports.biz 2Global Surgical Navigation Systems Market to Reach USD 295.5 Million in 2020 - Report by MarketResearchReports.biz 3Global Surgical Navigation Systems Market to Reach USD 295.5 Million in 2020 - Report by MarketResearchReports.biz 4Global Surgical Navigation Systems Market to Reach USD 295.5 Million in 2020 - Report by MarketResearchReports.biz 5Global Surgical Navigation Systems Market to Reach USD 295.5 Million in 2020 - Report by MarketResearchReports.biz 6Global Surgical Navigation Systems Market to Reach USD 295.5 Million in 2020 - Report by MarketResearchReports.biz 7Global Surgical Navigation Systems Market to Reach USD 295.5 Million in 2020 - Report by MarketResearchReports.biz 8Global Surgical Navigation Systems Market to Reach USD 295.5 Million in 2020 - Report by MarketResearchReports.biz 9
... to Differentiate Squamous From, Non-Squamous Non-Small Cell Lung Cancer (NSCLC), Classifying Squamous Cell, ... ... Percent., Accurate Diagnosis is Important for Guiding ... Rates of Severe or Fatal Hemorrhage in Patients With Squamous NSCLC ...
... California, April 3 ,Results of an independent ... the first clinically proven non-invasive solution,for fat ... focused,ultrasound will be presented at the American ... on April 4, 2008 in Kissimmee, Florida. ...
Cached Medicine Technology:Columbia University Medical Center and Rosetta Genomics Announce Columbia University's Submission of the First Cancer Diagnostic Test Based on Rosetta Genomics Proprietary MicroRNA Technology for Approval to the New York State Department of Health Clinica 2Columbia University Medical Center and Rosetta Genomics Announce Columbia University's Submission of the First Cancer Diagnostic Test Based on Rosetta Genomics Proprietary MicroRNA Technology for Approval to the New York State Department of Health Clinica 3Columbia University Medical Center and Rosetta Genomics Announce Columbia University's Submission of the First Cancer Diagnostic Test Based on Rosetta Genomics Proprietary MicroRNA Technology for Approval to the New York State Department of Health Clinica 4Columbia University Medical Center and Rosetta Genomics Announce Columbia University's Submission of the First Cancer Diagnostic Test Based on Rosetta Genomics Proprietary MicroRNA Technology for Approval to the New York State Department of Health Clinica 5Columbia University Medical Center and Rosetta Genomics Announce Columbia University's Submission of the First Cancer Diagnostic Test Based on Rosetta Genomics Proprietary MicroRNA Technology for Approval to the New York State Department of Health Clinica 6Columbia University Medical Center and Rosetta Genomics Announce Columbia University's Submission of the First Cancer Diagnostic Test Based on Rosetta Genomics Proprietary MicroRNA Technology for Approval to the New York State Department of Health Clinica 7UltraShape(R) Non-Invasive Fat Reduction and Body Contouring Clinical Study Results Featured at American Society for Laser Medicine and Surgery Meeting 2UltraShape(R) Non-Invasive Fat Reduction and Body Contouring Clinical Study Results Featured at American Society for Laser Medicine and Surgery Meeting 3
(Date:8/20/2014)... (PRWEB) August 20, 2014 Mixberry Media ... speech-enable their websites and create a new source of ... consume content by listening to a narration of their ... reader genders and languages. Users can now multitask: ... social networks, while consuming content. , Mixberry ...
(Date:8/20/2014)... Tappahannock, Va. (PRWEB) August 20, 2014 ... Dr. William Dameron , who joined its Warsaw Medical ... additional physician specialized in Family Medicine, is accepting new ... University School of Medicine, completed his residency at the ... relocating back to Virginia. , “I really like the ...
(Date:8/19/2014)... As moms and dads prepare their children to go ... normal routine of dropping their little ones off at daycare ... encourages them to use the opportunity to implement a ... Yarker explains, “Kids have small tummies, short attention spans, and ... food handouts, use snack time as another daily opportunity to ...
(Date:8/19/2014)... 2014 Crosley Law Firm, PC has reached ... against Lone Star Bakery for an undisclosed amount. The two ... and May of 2011, respectively. The injuries were caused by ... severe injury to the left hand of each man. , ... Bakery was short-staffed, having lost 200 of its, 500 workers ...
(Date:8/19/2014)... An editorial published in this week,s JAMA ... assessment tools when considering how to treat patients. Written ... Medical Center and chair of pediatrics at Boston University ... JAMA , the editorial examines results of a ... as an example of how doctors can often over-emphasize ...
Breaking Medicine News(10 mins):Health News:Mixberry Media, First To Offer Article Voice Narration with Integrated Audio Advertising 2Health News:Riverside Warsaw Medical Arts’ Dr. William Dameron Accepting New Patients 2Health News:Child Nutritionist Kristen Yarker Wants Parents to Rethink Kids’ Snacks This Fall 2Health News:Child Nutritionist Kristen Yarker Wants Parents to Rethink Kids’ Snacks This Fall 3Health News:Crosley Law Firm Reaches Settlement for Hand Amputation Victims at Commercial Bakery 2Health News:Review of clinical treatment of bronchiolitis in infants reveals over-reliance on one test 2
... Rating ... , ... (PRWEB) March 23, 2010 -- The Hartville Group Inc., which provides pet health insurance ... Insurance, Hartville Pet Insurance, and the Petshealth Care Plan, has received an A+ rating ...
... ... ... Sir Richard Bowlby keynotes ,Linking Forces, educational event with 16-year history in community , ... , ...
... , March 23 InterMune, Inc. (Nasdaq: ... (MAA), submitted on March 2 seeking approval of ... adults, was validated by the European Medicines Agency (EMA). Validation ... is complete and that the review process will begin on ...
... ... for Haiti survivors. , ... (PRWEB) March 23, 2010 -- Just like any other business, non-profit organizations must ... VoiceNation,s call center agents and auto attendants assist to fill the ...
... ... sustainable solution to the crisis in Haiti. The flexibility of these products can easily make ... ... -- Bosoley Solar Energy’s line of solar lights brings vital illumination to residents and aid ...
... ... than first thought. , ... -- Long known for being an excellent source of fiber, two recent studies suggest that apples ... antioxidants, previous research has suggested that apples may prevent or reduce the risks of certain types ...
Cached Medicine News:Health News:Pet Insurance Provider Hartville Group Gets A+ Rating From Better Business Bureau 2Health News:Pet Insurance Provider Hartville Group Gets A+ Rating From Better Business Bureau 3Health News:Children's Mental Health Conference Brings Together Top Research, Professionals, Parents and Community Agencies, April 8-9 in Miami 2Health News:Children's Mental Health Conference Brings Together Top Research, Professionals, Parents and Community Agencies, April 8-9 in Miami 3Health News:Children's Mental Health Conference Brings Together Top Research, Professionals, Parents and Community Agencies, April 8-9 in Miami 4Health News:Children's Mental Health Conference Brings Together Top Research, Professionals, Parents and Community Agencies, April 8-9 in Miami 5Health News:The European Medicines Agency Completes Validation Stage for InterMune's Marketing Authorization Application for pirfenidone 2Health News:The European Medicines Agency Completes Validation Stage for InterMune's Marketing Authorization Application for pirfenidone 3Health News:The European Medicines Agency Completes Validation Stage for InterMune's Marketing Authorization Application for pirfenidone 4Health News:The European Medicines Agency Completes Validation Stage for InterMune's Marketing Authorization Application for pirfenidone 5Health News:The European Medicines Agency Completes Validation Stage for InterMune's Marketing Authorization Application for pirfenidone 6Health News:The European Medicines Agency Completes Validation Stage for InterMune's Marketing Authorization Application for pirfenidone 7Health News:VoiceNation Helps Non-Profits Gather Funding for Those in Need 2Health News:VoiceNation Helps Non-Profits Gather Funding for Those in Need 3Health News:Bosoley Solar Light Set to Bring Haiti Out of the Post-Earthquake Darkness 2Health News:Go with Your Gut and Boost your Immune System with America's Favorite Fruit 2Health News:Go with Your Gut and Boost your Immune System with America's Favorite Fruit 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: