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Celator(R) Pharmaceuticals Presents New Data on Two Nano-Scale Delivery Platforms at the American Association for Cancer Research
Date:4/22/2010

ed that the proprietary HDPN approach -- encapsulating hydrophobic docetaxel prodrugs in block co-polymer nanoparticles -- produces prolonged circulation kinetics and enhanced therapeutic activity.  HDPN is currently undergoing comprehensive pre-clinical evaluation at the National Cancer Institute's (NCI) Nanotechnology Characterization Laboratory to support an eventual investigational new drug (IND) filing with the U.S. Food and Drug Administration.

The second presentation described results of a biodistribution comparison of CPX-351 to empty liposomes in a human leukemia xenograft model.  The plasma clearance of both CPX-351 and the empty liposomes was similar in both leukemic and non-leukemic mice and both formulations had similar organ distribution profiles.  However, accumulation of CPX-351 in bone marrow was 20 to 50 percent higher than that of the empty liposomes in cancer-free mice and 75 percent higher in leukemic mice after the first injection.  CPX-351 accumulation increased an additional 20 percent with subsequent injections.  The researchers concluded that the presence of encapsulated cytarabine:daunorubicin in CPX-351 markedly augmented marrow uptake and/or retention of the liposomes, a benefit that along with the prolonged circulation made possible by liposomal encapsulation itself, helps increase the exposure of tumor cells to the two active drugs at the synergistic ratio.

About Celator Pharmaceuticals, Inc.

Celator Pharmaceuticals, Inc., with locations in Princeton, NJ, and Vancouver, BC, is a privately held pharmaceutical company developing new and more effective therapies to treat cancer. CombiPlex®, the company's proprietary drug ratio technology platform, represents a novel approach that identifies molar ratios of drugs that will deliver a
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