Navigation Links
Celator(R) Pharmaceuticals Presents New Data on Two Nano-Scale Delivery Platforms at the American Association for Cancer Research
Date:4/22/2010

PRINCETON, N.J., April 22 /PRNewswire/ -- Celator Pharmaceuticals today announced data from animal studies demonstrating the superior bone marrow uptake of CPX-351 (Cytarabine:Daunorubicin) Liposome Injection, its lead clinical-stage program, as well as the enhanced circulation kinetics and efficacy of its preclinical hydrophobic docetaxel prodrug nanoparticle (HDPN) formulation were presented at the 101st Annual Meeting of the American Association for Cancer Research in Washington, DC (Abstracts 3698 and 5534).

"This research continues to expand our understanding of the activity and potential clinical benefits of improved cancer therapeutics based on our proprietary technologies; the CombiPlex® platform and the nanoparticle prodrug delivery platform," said Scott Jackson, chief executive officer of Celator Pharmaceuticals.  "The work done with CPX-351 helps explain the encouraging anti-leukemic activity we are seeing in Phase 2 clinical studies and the results seen with HDPN contributed to this product being selected for study by the NCI's Nanotechnology Characterization Laboratory."

In the first presentation, researchers reported on the circulation characteristics and anti-tumor activity of HDPN in mice bearing HT-29 human colorectal tumor xenografts.  Two nanoparticle preparations of the docetaxel pro-drug demonstrated significantly greater plasma half-lives than docetaxel formulated in polysorbate 80, the detergent drug solubilizer used in the marketed product Taxotere®. Furthermore, when administered at either their respective maximum tolerated doses or at equimolar doses to free docetaxel, the two HDPN preparations produced greater antitumor activity, as measured by tumor growth delay, than the free docetaxel.  These results confirm
'/>"/>

SOURCE Celator Pharmaceuticals
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Celator(R) Pharmaceuticals Announces Enrollment of First Patient in Phase 2 Study with CPX-351
2. Celator(R) Pharmaceuticals Announces Positive Phase 2 Results for CPX-1 in Treatment of Colorectal Cancer
3. Celator(R) Pharmaceuticals Successfully Uses Nanoparticles to Administer Hydrophobic Drug Combinations
4. Celator(R) Pharmaceuticals Reports CPX-351 Shows Anti-Cancer Activity in Leukemia Patients
5. Portola Pharmaceuticals Announces Initiation of Phase 1 Clinical Trial of PRT062607, an Oral, Syk-Specific Inhibitor for Chronic Inflammatory Disease Indications
6. Isis Pharmaceuticals to Present at the Barclays Capital 2010 Global Healthcare Conference
7. Amylin Pharmaceuticals to Present at The Barclays Capital 2010 Global Healthcare Conference
8. Astellas Announces Full Slate of Independent Director Nominees for Election at OSI Pharmaceuticals 2010 Annual Stockholders Meeting
9. ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2009 Financial Results
10. Poniard Pharmaceuticals Announces $6.3 Million Financing
11. MicuRx Pharmaceuticals Files Investigational New Drug Application for MRX-I
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... HARRISBURG, Pa. , Dec. 24, 2014  Commonwealth Cornerstone ... New Markets Tax Credits transaction on Tuesday to help fund ... Health Network (PHN) in Sharon . ... operating in Pennsylvania . It is the ... district, with more than 150 people on staff. ...
(Date:12/24/2014)... , Dec. 24, 2014  The International Trade Commission (ITC) ... (RMD) against BMC Medical. In a notice issued on December ... that ResMed,s patent on its humidifier was invalid. ... "monumental win". "We are very excited with the ITC,s decision ... that we have taken since the very beginning on the ...
(Date:12/24/2014)... , December 24, 2014 ... at an average rate of 8.1%. The US has ... knee and spine surgeries are the common orthopedic procedures ... have a lower penetration. Increased number of product recalls ... Non-metallic orthopedic devices have gained popularity in the industry ...
Breaking Medicine Technology:Commonwealth Cornerstone Group Announces $8 Million in Tax Credits to Expand and Consolidate Healthcare Services in Sharon 2Commonwealth Cornerstone Group Announces $8 Million in Tax Credits to Expand and Consolidate Healthcare Services in Sharon 3ITC Final Decision Goes Against ResMed (RMD) Monumental Win for 3B/BMC 2Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 2Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 3
(Date:12/24/2014)... 2014 The federal court overseeing ... blood thinner caused life-threatening episodes of internal bleeding ... for the proceeding, Bernstein Liebhard LLP reports. According ... plans to select lawyers to serve as Liaison ... appointing a Plaintiffs’ Steering Committee, which will coordinate ...
(Date:12/24/2014)... Mike Billings , PT, MS, CEEAA, ... Fenwick, PT, MBA, GCS, Director of Professional Development to ... passing of the Improving Medicare Post-Acute Care Transformation ... of the Infinicast, the two leaders discuss how the ... Act to standardize post-acute assessment data for quality, payment, ...
(Date:12/24/2014)... Dec. 24, 2014 (HealthDay News) -- Hepatitis C infection does ... to a new study. Treatment advances have made it ... many develop memory and thinking problems, mood swings and other ... said. It,s believed that long-term infections with other viruses ... affect the brain. One of the prime suspects has been ...
(Date:12/24/2014)... Tara Haelle HealthDay Reporter ... Teens are more likely to start smoking or drinking ... disorder (ADHD) or conduct disorder, new research suggests. ... about the risk of substance use as [these] children ... director at Cincinnati Pediatric Research Group, which is part ...
(Date:12/24/2014)... For chic ladies, new fashionable outfits are necessary ... their Holiday Wish List, Angeldress.co.uk has chosen some ... accent ladies’ holiday wardrobe by launching a promotion on its ... the discount of 80% off, like a cheap suit. , ... company’s chic wedding dresses are among the hottest items in ...
Breaking Medicine News(10 mins):Health News:Court Overseeing Federal Xarelto Lawsuits Issues Coordination Order, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal Xarelto Lawsuits Issues Coordination Order, Bernstein Liebhard LLP Reports 3Health News:Latest Episode of Infinicast Features Infinity Rehab President Discussing IMPACT Act of 2014 and Changes for Post-Acute Therapy Providers in 2015 2Health News:Hepatitis C Infection Isn't Related to HIV Brain Woes: Study 2Health News:ADHD May Raise Teens' Odds for Smoking, Drinking 2Health News:ADHD May Raise Teens' Odds for Smoking, Drinking 3Health News:Angeldress.co.uk Starts Its Big Sales by Offering Various Kinds of Cheap Clothes and Fashion Accessories 2
... the Cancer and Leukemia Group B (CALGB) and presented ... assessed the effectiveness of reducing the interval between successive ... survival rates in breast cancer// women. This study was ... developed in the 1980s that suggested the value of ...
... are exposed to smoke, as a reason of having parents ... C levels. Earlier studies have however, revealed the same// results ... 2 to 12 years, who were exposed to smoke at ... lower by an average of 3.2 micromoles per litre than ...
... approved GlaxoSmithKline's new drug Lamictal (lamotrigine) as an addition ... their existing therapy. This new indication is an expansion ... with partial seizures, and for the generalized seizures of ... older. ,Partial seizures are the most common type ...
... has been developed to prevent mix-ups over identification of ... newborns as barcodes, has been introduced in the maternity ... ,As soon as babies are born, their fingerprints, and ... which mother and baby wear on their wrists. The ...
... is bad for health is almost an established truth now. ... damage a single serving of pizza could do to our ... group, called the Centre //for Science in the Public Interest ... 15 varieties of pizzas and looked at dietary information provided ...
... often been connected to gaining excess weight. It has ... be related to the hormone leptin, which regulates appetite ... that leptin levels were high during smoking periods, thus ... leptin levels plummet leading to weight gain. ,A ...
Cached Medicine News:Health News:Survival rates in breast cancer patients improved with "Dose Dense Chemotherapy" 2Health News:Pizza is bad for health. But, do you know how bad? 2
The HT-PB is a implantable bipolar tined permanent pacing lead for stimulation of the ventricle....
The Guidant Fineline leads are bipolar endocardial and designed for permanent implantation with pulse generators for cardiac pacing....
Steroid-eluting, screw-in pacing lead...
... The Guidant Flextend ... transvenous pace/sense lead with ... The extendable/retractable helix design ... possibilities for permanent implantation ...
Medicine Products: