Navigation Links
CeeTox and Cellular Dynamics Collaborate to Offer Predictive In Vitro Test for Cardiotoxicity Using Human iPSC-derived Cells

MADISON, Wis., Aug. 14, 2012 /PRNewswire/ -- CeeTox and Cellular Dynamics International (CDI) today announced the introduction of a new, highly predictive cardiac safety screening service that utilizes human induced pluripotent stem (iPS) cell-derived cardiomyocytes.  The Cardiac Arrhythmia Assessment Screen (CAAS) combines CeeTox's expertise with in vitro toxicity screening and CDI's iCell® Cardiomyocytes to provide a comprehensive profile of drug-induced cardiac toxicity early in the drug development cycle.

Cardiotoxicity is the leading cause for late-stage drug attrition and market withdrawal, and the FDA mandates cardiotoxic safety data on drug candidates prior to entering clinical development. Currently used animal models, non-cardiac cell lines transformed to mimic heart cells, and cadaveric cells do not truly recapitulate human response and are therefore more likely to miss adverse side effects. CDI's iCell Cardiomyocytes are highly pure, fully functional human cardiac cells derived from induced pluripotent stem cells (iPSCs).  They are manufactured in reproducibly high quality and quantity to provide a more reliable, relevant and predictive in vitro model.

CeeTox's CAAS provides a fast, real-time assessment of drug-induced cardiac arrhythmias and biochemical cytotoxicity, thus enabling researchers to monitor both acute and longer-term effects, in contrast to the single time point results obtained with other assays.

Dr. James McKim, Chief Scientific Officer and CeeTox founder, said, "CeeTox's CAAS is an affordable addition to cardiac safety screening panels done during lead optimization, prior to candidate selection. More sensitive, predictable in vitro screens such as this that have direct implications for hazard identification and risk assessment can save drug developers valuable time and money."

"Increasingly researchers are publishing on the more predictive power of our iCell products in safety testing and discovery, and we're working closely with a number of pharma companies to develop assays that will become part of their standard screening platforms," said Chris Parker, Chief Commercial Office. "We're gratified to work with CeeTox as the first CRO to incorporate human iPSC-derived tissue cells as a standard human in vitro model into their screening services, thus reducing the use of animals in testing and providing a more predictive model of in vivo human response."

About CeeTox, Inc.

CeeTox, Inc. was founded in July of 2003 as a Contract Research Organization focused on in vitro toxicity screening of potential drug candidates and chemicals. CeeTox resides in 4,200-square-feet of state-of-the-art laboratory space in the Southwest Michigan Innovation Center (SMIC) (Kalamazoo, MI), a $13 million facility that serves as an incubator for new biotech companies in the Southwest Michigan area. The scientists at CeeTox have a collective experience of more than 100 years in areas of cell culture, biochemistry, and toxicology. The team has analyzed more than 4,000 new chemical entities and has repeatedly demonstrated the value of early in vitro toxicity data in the drug discovery process. See

About Cellular Dynamics International, Inc.

Cellular Dynamics International, Inc. (CDI) is a leading developer of next-generation stem cell technologies for drug development, cell therapy, tissue engineering and organ regeneration. CDI harnesses its unique manufacturing technology to produce differentiated tissue cells from any individual's stem cell line in industrial quality, quantity and purity. CDI is accelerating the adoption of pluripotent stem cell technology, adapting its methods to fit into standard clinical practice by the creation of individual stem cell lines from a standard blood draw. CDI was founded in 2004 by Dr. James Thomson, a pioneer in human pluripotent stem cell research at the University of Wisconsin-Madison. CDI's facilities are located in Madison, Wisconsin. See

SOURCE Cellular Dynamics International, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Life Technologies and Cellular Dynamics International Partner for Global Commercialization of Novel Stem Cell Technologies
2. Cellular Dynamics Launches MyCell™ Services
3. Transonic Systems Selects Infinity Info Systems To Implement Microsoft Dynamics CRM To Drive Business Performance And Operational Excellence
4. Luminex Corporation and University Hospital of Wales Collaborate During Olympic Games
5. Life Technologies and SATuRN Collaborate to Increase Access to HIV Testing in Africa
6. Sanofi US Launches Collaborate Activate Innovation Challenge
7. Carolinas HealthCare System and Edison Nation Collaborate to Drive Medical Innovation and Technology
8. AstraZeneca and Leading Academic Scientists to Collaborate on Alzheimers Disease Research
9. AstraZeneca And Cellworks Collaborate To Find New Treatment For Tuberculosis
10. Optimer Pharmaceuticals and Specialised Therapeutics Australia Collaborate to Commercialize Fidaxomicin for Clostridium difficile Infection in Australia and New Zealand
11. JDRF and BD Collaborate to Develop More Accurate and Reliable Glucose Monitoring Devices for People with Type 1 Diabetes
Post Your Comments:
(Date:11/27/2015)... Nov. 26, 2015 ... of the "2016 Global Tumor Marker ... Volume and Sales Segment Forecasts, Innovative Technologies, ... report to their offering. --> ... the "2016 Global Tumor Marker Testing ...
(Date:11/26/2015)... UTRECHT , Nederland, November 26, 2015 ... --> Een nieuwe aanpak combineert ... van gevorderde kanker. ... -->      (Photo: ... van het Leids Universitair Medisch Centrum (LUMC) ...
(Date:11/26/2015)... , November 26, 2015 ... of the "2016 Future Horizons and ... Abuse Testing Market: Supplier Shares, Country Segment ... to their offering. --> ... "2016 Future Horizons and Growth Strategies ...
Breaking Medicine Technology:
(Date:11/27/2015)... ... ... According to an article published November 15th by ABC News, ... in light of the recent terrorist attacks in Paris, other cities are taking extra ... from reaching U.S. soil. Especially around special events that may be high-profile in nature, ...
(Date:11/27/2015)... CA (PRWEB) , ... November 27, 2015 , ... Lizzie’s ... , The company is offering customers 10% off of their purchase of lice treatment ... treatment at full price. According to a company spokesperson. “Finding lice is a sure ...
(Date:11/27/2015)... ... 2015 , ... Intellitec Solutions announced today that they have ... as Microsoft’s official group for end users of Dynamics SL ERP software, the ... experts and representatives. Intellitec Solutions’ membership status demonstrates their ongoing commitment to the ...
(Date:11/27/2015)... ... 2015 , ... The men and women on this list ... the country. They have overseen financial turnarounds, shown commitment to their community through ... as a whole through their advocacy and professional efforts. , Becker's Hospital Review ...
(Date:11/26/2015)... Las Vegas, NV (PRWEB) , ... November 26, 2015 , ... ... holiday shopping strategy. Many customers choose to buy during the Black Friday and ... holiday gifts. Shoppers don’t need to search the Internet high and low to find ...
Breaking Medicine News(10 mins):