Navigation Links
CeNeRx Announces FDA IND Approval for its Neuroprotective Agent in Chemotherapy-Induced Neuropathy and Results From First Human Study
Date:2/9/2011

RESEARCH TRIANGLE PARK, N.C., Feb. 9, 2011 /PRNewswire/ -- CeNeRx BioPharma, Inc., a clinical-stage company developing and commercializing innovative treatments for diseases of the central nervous system (CNS), today announced FDA approval of its IND and reported the first clinical results in humans for CXB909, a novel agent that has demonstrated utility in preclinical models of neuroprotection and neurodegenerative disorders.  CXB909 is a small molecule, orally active agent that enhances the effects of nerve growth factor (NGF) and is also believed to promote synthesis of acetylcholine.  CeNeRx is now preparing to launch further Phase I studies of CXB909 targeting chemotherapy-induced peripheral neuropathy as its first potential indication.  

CXB909 appears to enhance cholinergic tone and is a downstream enhancer of the effects of NGF, a naturally occurring neurotrophic factor that is important for the function and survival of several types of neurons.  NGF may help prevent or reverse the neuronal damage that is implicated in the peripheral neuropathies associated with cancer chemotherapy, diabetes, kidney disease, and other conditions. The degeneration of certain neurons associated with Alzheimer's disease and Huntington's disease may also be ameliorated by increased levels of NGF.  

Past attempts to use recombinant versions of NGF to prevent and treat neuron-damaging conditions were stymied by its lack of drug-like properties.  In contrast, CXB909 crosses the blood-brain barrier, has a long half-life and is orally available.  Results from an initial Phase I study in 26 subjects showed that single doses of CXB909 administered orally resulted in good levels of drug exposure and were well-tolerated.

"CXB909 has been shown to increase the action of endogenous NGF and enhance cognition and neuroprotection in multiple preclinical models, and it has demonstrated good safety in animal and early human studies," sa
'/>"/>

SOURCE CeNeRx BioPharma, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. CeNeRx Initiates Phase II Trial of TriRima™ as Monotherapy in Treatment Resistant Depression
2. CeNeRx BioPharma Completes $13 Million Series C Financing
3. CeNeRx BioPharma Obtains Rights to Novel Drug Candidate for Prevention and Treatment of Neurodegeneration Disorders
4. CeNeRx BioPharma Initiates Phase II Clinical Trial of Its Novel Antidepressant Agent Tyrima(TM)
5. CeNeRx BioPharma Finalizes Plans to Initiate Phase II Trials for Its Novel Antidepressant Agent Tyrima(TM) Using Innovative Brain Imaging Study
6. CeNeRx BioPharma Announces Successful Completion of Phase l Clinical Program for Novel Antidepressant Agent Tyrima(TM)
7. Concentric Medical Announces First Patients Enrolled In TREVO 2 Clinical Trial
8. Telik Announces Presentation and Webcast at 13th Annual BIO CEO & Investor Conference
9. DURECT Announces Launch of First FDA Approved SABER™-Injectable Peptide Product
10. Genomic Health Announces Year-End 2010 Financial Results, Provides 2011 Financial Outlook
11. Ulthera Announces $10.5 Million in Series C Venture Capital Funding
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... ANGELES , Aug. 27, 2014   Los ... now offers AcceleDent® Aura to patients who want to ... orthodontic care available at the OrthoSpaceship, all patients have ... better-looking teeth. This system can be used by most ... their rate of progress by using the AcceleDent® Aura ...
(Date:8/27/2014)... 2014 Reportlinker.com announces that a new ... Global Heart Valve Repair and Replacement ... About Heart Valve Repair and Replacement ... which control the flow of blood during the ... diseases such as valvular stenosis, valvular insufficiency or ...
(Date:8/27/2014)... Aug. 27, 2014 Reportlinker.com announces that ... its catalogue: Global Animal Health Market ... About Animal Health Animal health refers to ... treat animals to enhance their quality of life, ... animal food. The Global Animal Health market covers ...
Breaking Medicine Technology:Los Angeles Orthodontist, Dr. Isaac Hakim, is Now Offering AcceleDent Aura 2Global Heart Valve Repair and Replacement Market 2014-2018 2Global Heart Valve Repair and Replacement Market 2014-2018 3Global Heart Valve Repair and Replacement Market 2014-2018 4Global Animal Health Market 2014-2018 2Global Animal Health Market 2014-2018 3Global Animal Health Market 2014-2018 4Global Animal Health Market 2014-2018 5Global Animal Health Market 2014-2018 6Global Animal Health Market 2014-2018 7
... M. Bergman, Chairman and Chief Executive Officer of ... the largest provider of health care products and ... impact of a world without effective antibiotics before ... leaders of society at the World Economic Forum,s ...
... 2012  Vision-Sciences, Inc. (NASDAQ:  VSCI), a leading provider ... disposable EndoSheath® technology, today announced its participation at ... TIME: 2:30 PM EST ... "register/ watch event now" button. This ...
Cached Medicine Technology:Henry Schein's Chairman and CEO Addresses the World Economic Forum 2Henry Schein's Chairman and CEO Addresses the World Economic Forum 3Vision-Sciences, Inc. to Webcast, Live, at RetailInvestorConferences.com on February 2nd 2
(Date:8/27/2014)... What’s next for 14 year old Sriram ... National Spelling Bee? Sririam will visit Philadelphia on Friday, ... Wills Eye Hospital.     , The teen from Painted Post, ... day. , Wills Eye Ophthalmologist-in-Chief, Dr. Julia Haller will ... visual diagnostic testing. He will also tour historic ...
(Date:8/27/2014)... The newest Abington Health Center ... 2014. This new 15,000 square foot, $5 million project ... practices and walk-in laboratory services. , “Adding ... for Abington Health as the healthcare landscape changes,” said ... a location in Lower Gwynedd allows us to consolidate ...
(Date:8/27/2014)... -- Overconfident people are better at convincing others that ... are more likely to get promotions and reach high-level ... that these "self-deceived" people are also more likely to ... And finally, people who underestimate themselves are regarded ... British researchers. Their findings were published Aug. 27 in ...
(Date:8/27/2014)... Recent growth in health care spending for commercially insured ... medical services, rather than increased use, according to a ... for Health Policy & Clinical Practice, published in the ... Care . , There is increasing concern that consolidation ... prices faced by payers and, ultimately, consumers," said Carrie ...
(Date:8/27/2014)... August 27, 2014 Driven by the ... is expected to grow steadily during the next few ... reach 1.381 billion meters by end-2017. Tightness is an ... are one of the most-used parts in an automobile. ... stood at 995 million meters, up just under 15% ...
Breaking Medicine News(10 mins):Health News:Scripps National Spelling Bee Co-Champion and Aspiring Ophthalmologist Coming to Wills Eye Hospital in Philadelphia 2Health News:Abington Health Opens New Health Center in Lower Gwynedd 2Health News:Overconfident Folks May Blind Others to Their Real Abilities 2Health News:Tracking spending among the commercially insured 2Health News:Automobile Weatherstrip Sector in China Analysed in New SinoMarketInsight Research Study Published at MarketPublishers.com 2Health News:Automobile Weatherstrip Sector in China Analysed in New SinoMarketInsight Research Study Published at MarketPublishers.com 3
... , TUESDAY, June 7 (HealthDay News) -- ... among children, teens and young adults worldwide, according to ... collected in 2004 found that neuropsychiatric disorders -- including ... for 45 percent of the disease burden among those ...
... will test parts of Galveston Bay for toxic chemicals ... best way to handle those pollutants., Hanadi Rifai will ... Commission on Environmental Quality (TCEQ) grant that is an ... similar research in the Houston Ship Channel. The latest ...
... Reporter , MONDAY, June 6 (HealthDay News) -- There,s ... localized prostate cancer with radiation is a better option ... a study funded by the Agency for Healthcare Research ... available literature on radiation and prostate cancer, including 10 ...
... , TUESDAY, June 7 (HealthDay News) -- Being in a ... from infection with HIV, new research suggests. In fact, ... gay couples are six times more likely to have unprotected ... gay men account for nearly 70 percent of all new ...
... is, in fact, one of the central questions in biochemistry. ... long, coiled strings of amino acids that make up proteins ... By understanding how proteins fold, and what structures they are ... able to move closer to predicting their function. ...
... meet this week to review progress and chart the future ... General Assembly High-Level Meeting on AIDS (UNGASS 2011) in New ... ensure the inclusion of HIV cure research and its global ... political decisions and funding strategies. In this historic ...
Cached Medicine News:Health News:Study Ranks Mental Health as Young People's Top Health Problem 2Health News:University of Houston researcher receives grant to study water pollutants 2Health News:Jury Still Out on Radiation for Early Prostate Cancer 2Health News:Jury Still Out on Radiation for Early Prostate Cancer 3Health News:For Gay Men, Serious Relationships Still Harbor Risks for HIV 2Health News:Protein folding made easy 2Health News:International AIDS Society urges world leaders at UN General Assembly High-Level Meeting on HIV/AIDS to integrate a fourth pillar -- HIV cure research -- into the global response to the epidemic 2Health News:International AIDS Society urges world leaders at UN General Assembly High-Level Meeting on HIV/AIDS to integrate a fourth pillar -- HIV cure research -- into the global response to the epidemic 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: