Navigation Links
Carolus Therapeutics and The Alpha-1 Project Collaborate to Validate CT-2009 Target as Important in Human Disease
Date:8/27/2013

pathological processes leading to COPD for over 35 years, and based on the data available thus far, I see great potential in this 'anti-platelet' approach," said Robert A. Stockley, MD, DSc, Professor of Medicine at the University Hospital Birmingham and one of the scientists who will study the samples in collaboration with the Carolus team. "If we are successful in our efforts to link the heteromer to AAT COPD, we could open up a completely new way to treat both the rare, genetic form of COPD as well as the more common type, which is the fourth leading cause of death worldwide."

Carolus' lead compound, CT-2009, selectively targets the heteromer, which has been shown in preclinical efforts to be present and elevated in AAT and COPD patient samples. The goals of the collaborative effort between Carolus and TAP will be to understand, among other things, whether the concentration of the heteromer is related to the severity and progression of disease, and eventually whether heteromer levels can be successfully modulated by CT-2009 in patients.

"Novel targets for disease present significant opportunities for more effective and safer treatments for patients. However, they may represent risky, unproven territory," noted Court R. Turner, CEO of Carolus Therapeutics. "Validating such targets in humans is a significant milestone to building value in the compounds. With this collaboration, we will have the opportunity to validate the heteromer as a target for AATD COPD specifically, and, perhaps, COPD in general."

About CT-2009

CT-2009, is an IND-ready molecule that selectively disrupts the RANTES:PF4 heteromer with potential therapeutic utility in respiratory, pulmonary, cardiovascular and other indications. Initial focus with CT-2009 has been on Alpha-1 Antitrypsin Deficiency (and COPD) and Cystic Fibrosis. CT-2009 has demonstrated robust preclinical efficacy in relevant animals models of these diseases.

About
'/>"/>

SOURCE Carolus Therapeutics, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Echo Therapeutics Announces Management Changes
2. aTyr Pharma Awarded Two Patents from USPTO to Support Development of New Therapeutics Based on Physiocrine Biology
3. aTyr Pharma Expands Executive Leadership Team to Support Development of New Therapeutics Based on Physiocrine Biology
4. Arcturus Therapeutics Acquires Cutting-Edge UNA Patent Estate from Marina Biotech
5. PTC Therapeutics Reports Second Quarter 2013 Financial and Corporate Results
6. Aratana Therapeutics Reports Second Quarter 2013 Financial Results
7. Breckenridge Enters Into Agreement to Acquire Certain Cypress Assets from Pernix Therapeutics
8. Northwest Biotherapeutics Announces Registered Direct Offering
9. Nektar Therapeutics Reports Financial Results for the Second Quarter of 2013
10. Echo Therapeutics Announces Second Quarter 2013 Financial Results
11. Pain Therapeutics - Drugs, Markets and Companies - 2013 Report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... -- Research and Markets  has announced the addition of ... report to their offering. The Central Nervous ... largest segments of pharmaceuticals industry. The numbers of CNS disorders ... were unable to meet the market requirements. There has been ... especially over the past two decades. The market for CNS ...
(Date:8/29/2014)... Aug. 29, 2014   Vittamed Corporation , a neurodiagnostics ... announced today that T. (Teo) Forcht Dagi , MD, ... Board of Directors. " Teo Forcht Dagi ... neurosurgery, medical innovation and venture capital," said Remis Bistras ... to add his clinical, strategic, and entrepreneurial expertise to our ...
(Date:8/29/2014)... , Aug. 29, 2014 Research ... "Global Multiple Sclerosis Drugs Market 2014-2018" report ... a chronic, inflammatory medical condition that results in demyelination, ... because of an abnormal response by the immune system, ... It is a potentially debilitating disease in which the ...
Breaking Medicine Technology:US CNS Disorders Drug Pipeline Insight 2014 2Vittamed Adds Prominent Neurosurgeon and Venture Capitalist T. Forcht Dagi to Board of Directors 2Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 2Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 3
(Date:8/30/2014)... 30, 2014 Serving contented clients since ... Profit By Outsourcing is now offering discount for ... company gives emphasize on putting forward the best of ... clients. Their dedicated team of professionals and web developers ... can handle even the critical issues of web development ...
(Date:8/30/2014)... Saturday 30 August 2014: Transvenous lead extraction (TLE) ... according to data from the European Lead Extraction ConTRolled ... ESC Congress 2014 by Dr Maria Grazia Bongiorni, chair ... "The number of cardiac implantable electronic devices (CIED) implant ... technology the number of complications has increased and leads ...
(Date:8/30/2014)... (PRWEB) August 30, 2014 Top10BestSEOHosting.com ... experienced researchers have announced that HostGator.com http://secure.hostgator.com/~affiliat/cgi-bin/affiliates/clickthru.cgi?id=seohosts ... the current market. Also, they has announced that ... webmasters. , Hostgator, one of the Top ... supplier of cheap Windows hosting, and it offers ...
(Date:8/30/2014)... LiveStreamingFitness.com, a company dedicated to providing live at home fitness ... to announce it has been recognized as one of the ... ABC’s Good Morning America. , As aired ... “Live Streaming Fitness is the hottest new trend in fitness. ... workout…to boot camp at Life Streaming Fitness for less than ...
(Date:8/30/2014)... (PRWEB) August 30, 2014 McLeod's Sunset ... service auto repair shop with strong ties to the community ... is happy to announce they have been chosen by ... pick for auto repair. , Tim McLeod’s father, Norris ... Service sixty years ago. Although his son, Tim runs the ...
Breaking Medicine News(10 mins):Health News:Profit By Outsourcing Offering Discount for Labor Day on all Web Development Services 2Health News:Transvenous lead extraction clinically successful in 98 percent of cases 2Health News:Transvenous lead extraction clinically successful in 98 percent of cases 3Health News:Top10BestSEOHosting.com: HostGator.com Is The Best Windows Hosting Supplier 2Health News:LiveStreamingFitness.com is New Trend In Fitness 2Health News:McLeod's Sunset Park Auto Service Celebrates 60 Years Honored with Best of South Tampa 2
... Team Health Inc.,s parent,company, Team Finance LLC ("TeamHealth" ... year and the fourth quarter ended December 31, ... to exit the anesthesia,management services business line. During ... within this operation and the final,phase of this ...
... by Dennis Carson M.D., professor of medicine and director of ... University of California, San Diego (UCSD) has identified a potent ... in the South Pacific. The properties of somocystinamide A ... online in Proceedings of the National Academy of Science the ...
... 11 iCAD, Inc. (Nasdaq:,ICAD), an industry-leading provider ... of cancer, today announced that the,Company,s fourth quarter ... before market open on Thursday, March 6, 2008. ... call scheduled for 10:00 am,ET., Shareholders and ...
... Fla., Feb. 11 Lincare Holdings,Inc. (Nasdaq: LNCR ... services delivered to patients in the home, today announced,financial ... 31, 2007., For the quarter ended December 31, ... of $368.1 million for the fourth quarter of,2006. The ...
... Less than one fourth of physicians specializing in geriatrics, ... accurately predict the whether patients with heart failure are ... found. , The ability to determine whether patients ... clinical care, impacting key patient-care decisions such as therapeutic ...
... 11 Internationally renowned health,professionals are joining forces ... Truth of Health Conference, April 3-6, 2008 in,Taos, ... presented on some,of today,s most pertinent health issues ... and spiritual health., Based on extensive medical ...
Cached Medicine News:Health News:Team Finance LLC Announces Fiscal 2007 Results 2Health News:Team Finance LLC Announces Fiscal 2007 Results 3Health News:Team Finance LLC Announces Fiscal 2007 Results 4Health News:Team Finance LLC Announces Fiscal 2007 Results 5Health News:Team Finance LLC Announces Fiscal 2007 Results 6Health News:Team Finance LLC Announces Fiscal 2007 Results 7Health News:Team Finance LLC Announces Fiscal 2007 Results 8Health News:Team Finance LLC Announces Fiscal 2007 Results 9Health News:Team Finance LLC Announces Fiscal 2007 Results 10Health News:UCSD research team identifies novel anticancer drug from the sea 2Health News:iCAD To Release Fourth Quarter and Year End 2007 Financial Results on Thursday, March 6, 2008 2Health News:iCAD To Release Fourth Quarter and Year End 2007 Financial Results on Thursday, March 6, 2008 3Health News:Lincare Holdings Inc. Announces Fourth Quarter and Year Ended 2007 Financial Results 2Health News:Lincare Holdings Inc. Announces Fourth Quarter and Year Ended 2007 Financial Results 3Health News:Lincare Holdings Inc. Announces Fourth Quarter and Year Ended 2007 Financial Results 4Health News:Lincare Holdings Inc. Announces Fourth Quarter and Year Ended 2007 Financial Results 5Health News:Lincare Holdings Inc. Announces Fourth Quarter and Year Ended 2007 Financial Results 6Health News:Lincare Holdings Inc. Announces Fourth Quarter and Year Ended 2007 Financial Results 7Health News:Doctors uncertain about approaches to care for heart failure patients, SLU study finds 2Health News:Conference to Explore America's Health Challenges 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: