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Carolus Therapeutics and The Alpha-1 Project Collaborate to Validate CT-2009 Target as Important in Human Disease
Date:8/27/2013

SAN DIEGO, Aug. 27, 2013 /PRNewswire/ -- Carolus Therapeutics, Inc. and The Alpha-1 Project, Inc. (TAP), a wholly-owned subsidiary of the Alpha-1 Foundation, today announced that they are collaborating to characterize human biological samples for the presence of the novel target, RANTES:PF4 heterodimer (the heteromer), a soluble protein complex that is secreted by activated platelets and implicated in many inflammation-related diseases, including genetic emphysema and COPD (chronic obstructive pulmonary disease). As a part of the collaboration, TAP is making an equity investment in Carolus. Terms of the collaboration and equity investment were not disclosed.

"COPD is a major and growing cause of death in the United States, and treatment approaches are generally limited to bronchodilators and anti-inflammatory agents," said John Walsh, Co-founder, President and CEO of the Alpha-1 Foundation and Co-founder and President of the COPD Foundation. "Those of us with Alpha-1 are among a small minority with a specific treatment. But clearly, all patients need more and better ways to manage these diseases. Creatively investing in potential new therapies is exactly the reason TAP was created. Carolus is approaching COPD treatment from a completely novel mechanism, which we hope will open up new ways to help patients, and we are committed to supporting their work."

Genetic emphysema is caused by a deficiency in alpha-1 antitrypsin (AAT), a protein that protects tissues such as lung from the destructive enzymes of inflammatory cells. In people who have AAT deficiencies, these inflammatory enzymes cause excessive breakdown of lung tissue, resulting in emphysema – also a key feature of a syndrome known as COPD (chronic obstructive pulmonary disease).

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SOURCE Carolus Therapeutics, Inc.
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