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Cardium's Innercool Therapies Unit Announces Publication of Positive Effects of Early and Rapid Hypothermia Following Heart Attack
Date:4/15/2008

SAN DIEGO, April 15 /PRNewswire-FirstCall/ -- Cardium Therapeutics (Amex: CXM) and its operating unit InnerCool Therapies announced today that positive findings from a preclinical study, demonstrating a new and expanded benefit of early rapid hyperthermia (cooling) for the potential treatment of acute myocardial infarction (heart attack), has been published online by BioMed Central (BMC) Cardiovascular Disorders (2008, 8:7, April 10, 2008).

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The study, conducted by a team of interventional cardiologists at the Lund University Hospital, Sweden, evaluated the effect of early and rapid cooling induced by a combination of cold saline infusion along with InnerCool's endovascular Celsius Control(TM) System, before or immediately after reperfusion when coronary blood flow was restored in the heart in a porcine heart attack model. Results from this study demonstrated that rapid cooling (to <35 degrees Celsius) prior to reperfusion significantly reduced overall myocardial infarct size (a measure of tissue damage in the heart) and protected the heart from other injury.

"We believe that InnerCool's low-profile, high-performance endovascular cooling system has the capacity to achieve rapid cooling within the short time available before coronary reperfusion must occur in order to potentially limit the amount of damage due to reperfusion injury following heart attack," stated Christopher J. Reinhard, Chairman and Chief Executive Officer of
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SOURCE Cardium Therapeutics, Inc.
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