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Cardium Reports on Applicability of Corgentin to Stem Cell Therapies: Independent Studies Indicate that Ad5IGF-1 Potentiates Stem Cells to Improve Cardiac Function After Heart Attack
Date:3/27/2009

vivo before reintroduction into the body, tend to loose certain capabilities required for effective binding and retention within injured heart tissue such as that occurring after a heart attack. We believe that the effectiveness of these stem cells can be substantially improved through a targeting mechanism that involves the binding of the CXC chemokine receptor 4 (found on these stem cells in the bone marrow but reduced after ex vivo expansion) with the stromal-derived factor-1 alpha ligand that is expressed in ischemic heart tissue following a heart attack. This suggests that treatment of mesenchymal stem cells ex vivo with an Ad5IGF-1 biologic, such as Cardium's Corgentin product candidate, will lead to local production of insulin-like growth factor-1 protein to enhance this process and amplify the delivery and retention of stem cells within injured heart tissue. The recently-published research findings from the University of Cincinnati provide independent support of this possible mechanism of action and underscore the potential use of Cardium's Corgentin candidate in stem cell therapies aimed at the treatment of heart attack and other indications," stated Cardium's Chief Scientific Officer, Gabor M. Rubanyi, M.D., Ph.D.

"Cardium has been developing a portfolio of innovative DNA-based growth factor therapeutics for cardiovascular and related applications. Our Corgentin (Ad5IGF-1) product candidate is designed to lessen tissue injury and promote myocardial repair and restoration following a heart attack," noted Christopher J. Reinhard, Cardium's Chief Executive Officer. "The well-documented biological properties of IGF-1 protein include the inhibition of programmed cell death or apoptosis, adaptive cardiomyocyte hypertrophy, proliferation of cardiac progenitor cells and angiogenesis. These observations provide a strong scientific rationale for the clinical development of an IGF-1 based therapy.

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SOURCE Cardium Therapeutics
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