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Cardium Reports Non-Healing Wounds Continue to Challenge Patients and Healthcare Providers
Date:8/27/2009

APA article discusses other advanced wound healing approaches for the treatment of diabetic foot ulcers that include bioengineered skin substitutes, as well as medical devices that provide negative pressure wound therapy. Bioengineered skin substitutes represent an important class of products that include two FDA-approved dermal graft substitutes: Apligraf(R) a combination of human fibroblasts and keratinocytes and Dermagraft(R), consisting of human fibroblasts alone. Based on product labeling and usage instructions, both products require multiple grafting procedures by physicians into the wound area (and may require the use of sutures) on a weekly or bi-weekly basis, by physicians over a 12-week period. Some products in this class require low temperature storage (-70 degrees Celsius) or need to be special ordered by a physician immediately prior to patient treatment because of a very limited shelf life (approximately 10 days).

Negative Pressure Wound Therapy - Negative pressure wound therapy for the treatment of diabetic ulcers consists of medical devices employing the use of specialized wound dressings connected to an air supply line linked to a microprocessor-controlled air pump to create a healing environment around the wound. These systems are designed to create a moist wound environment, reduce edema and promote formation and perfusion of granulation tissue. They have been proven to be safe and effective, accommodate a wide range of wound sizes, and are used in a broad range of other types of wounds including surgical as well as trauma wounds. However, effective therapy generally requires that these systems be used by patients on a 24/7 basis for up to 16 weeks (based on recently published studies). As a result, they are complex and challenging for patients to use over extended periods of time, impair patient mobility, and require repeated physician visits, equipment cleansings and dressing changes.

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SOURCE Cardium Therapeutics
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