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Cardium Reports Non-Healing Wounds Continue to Challenge Patients and Healthcare Providers
Date:8/27/2009

to 20 weeks, and (2) enhance acceptance by the medical community due to improved ease of use (as a pre-filled syringe, requiring only standard refrigeration and a 15-18 month shelf life), when compared to other treatment options.

With this targeted registration profile, Cardium believes that Excellarate offers the unique potential to become an important new therapeutic class that, in certain cases, may supplant the use of current healing agents and medical devices, and, in certain wounds and under various medical conditions, may be used in concert with other agents and current therapies within an expanding spectrum of advanced wound care solutions. The Company believes that, because of the complex nature of lower extremity diabetic ulcers, patients will benefit from the availability of a multitude of wound healing agents and therapies that can be tailored to appropriately address their specific medical conditions.

Benchmarks with Current Therapy

Regranex Topical Gel - As referenced in JAAPA, current therapy includes the use of a topical protein-based growth factor gel, Regranex (becaplermin; 0.01% recombinant platelet-derived growth factor-B). Regranex is currently the only FDA-approved advanced care biologic topical agent for the treatment of patients with lower extremity neuropathic diabetic foot ulcers. It was initially developed by Johnson & Johnson and is currently marketed by Systagenix. Regranex which is patient administered, requires daily application followed by a daily cleansing 12 hours after the drug treatment over a 20-week period. As a result, during the prescribed 20-week treatment period, Regranex patients are required to undertake approximately 280 interventions (drug administrations and cleansings) to achieve the potential maximum healing effect.

Bioengineered Skin Substitutes - In addition to protein-based therapy, the JA
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SOURCE Cardium Therapeutics
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Related medicine technology :

1. Cardium Completes Initial Patient Evaluation Period for MATRIX Phase 2b Excellarate Clinical Study
2. Cardium Announces Completion of Patient Recruitment in Phase 2b Clinical Trial of Excellarate(TM) for the Potential Treatment of Diabetic Foot Ulcers
3. Cardium Reports on Applicability of Corgentin to Stem Cell Therapies: Independent Studies Indicate that Ad5IGF-1 Potentiates Stem Cells to Improve Cardiac Function After Heart Attack
4. Cardiums InnerCool Announces Positive Benefits of Cooling During Robotic-Assisted Prostate Surgery Published in Urology
5. Cardium Reports on Second Quarter 2008 Highlights and Financial Results
6. Cardium Announces Appointment of Paul A. Foster, M.D. to Lead Generx and Excellarate Late-Stage Development Activities
7. Cardiums Innercool Therapies Unit Announces Publication of Positive Effects of Early and Rapid Hypothermia Following Heart Attack
8. Cardium and Tissue Repair Companys Excellarate Candidate for Healing Diabetic Wounds Gains Media Focus in Multiple Regions Across U.S.
9. Wyoming Department of Healths Pay-for-Participation Program Reports Positive Clinical Outcomes
10. Isis Reports Strong Financial Results and Highlights for Second Quarter of 2009
11. Nektar Therapeutics Reports Second Quarter 2009 Financial Results
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