Navigation Links
Cardium Announces New Research Findings: Excellagen Product Candidate Activates Platelet Release of PDGF, an Important Growth Factor Fundamental to the Wound Healing Process
Date:10/13/2010

tive control, Excellagen (2.6% formulated bovine type I collagen) was tested for its ability to activate platelets.

New Preclinical Study and Clinical Implications

For these supplemental studies, the release of PDGF-AB was measured using an Enzyme-Linked Immunosorbent Assay (ELISA).  Data from this study now confirm that Excellagen combined with human platelet concentrate results in clot formation and platelet activation. At 24 hours after clot initiation, comparable levels of released PDGF-AB (~10 ng/mL) were detected in the thrombin- and Excellagen-induced clots. By 48 hours, measurable PDGF-AB was still detectable in the thrombin samples, whereas Excellagen samples had returned to baseline (negative control level).  

The Excellagen product candidate is believed to have several attributes beneficial to the promotion of wound healing, including providing binding sites for growth factors (e.g. PDGF-BB) and a scaffold for migration of cells responsible for generation of granulation tissue. The current findings add to this repertoire of attributes and are consistent with a role of platelet activation and the release of growth factors for 24-48 hours immediately following application of Excellagen to newly-debrided wounds.

Based on the Matrix Phase 2b study protocol, treatment with Excellagen was limited to one application or a second application (if the wound had not healed) four weeks following the initial treatment during the 12 week study period.  Data from this study indicated that the Excellagen product candidate was safe and well-tolerated by all patients receiving one or two treatments.  Based on this safety data and the immediate acceleration of healing, the Company believes that the treatment response observed in the Matrix study offers the potential to be further amplified and sustained in actual clinical practice through multiple treatments with increased frequency.  Cardium's Excellagen fo
'/>"/>

SOURCE Cardium Therapeutics
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Cardium and Tissue Repair Companys Excellarate Candidate for Healing Diabetic Wounds Gains Media Focus in Multiple Regions Across U.S.
2. Cardiums Innercool Therapies Unit Announces Publication of Positive Effects of Early and Rapid Hypothermia Following Heart Attack
3. Cardium Announces Appointment of Paul A. Foster, M.D. to Lead Generx and Excellarate Late-Stage Development Activities
4. Cardium Reports on Second Quarter 2008 Highlights and Financial Results
5. Cardiums InnerCool Announces Positive Benefits of Cooling During Robotic-Assisted Prostate Surgery Published in Urology
6. Cardium Reports on Applicability of Corgentin to Stem Cell Therapies: Independent Studies Indicate that Ad5IGF-1 Potentiates Stem Cells to Improve Cardiac Function After Heart Attack
7. Cardium Announces Completion of Patient Recruitment in Phase 2b Clinical Trial of Excellarate(TM) for the Potential Treatment of Diabetic Foot Ulcers
8. Cardium Completes Initial Patient Evaluation Period for MATRIX Phase 2b Excellarate Clinical Study
9. Cardium Reports Non-Healing Wounds Continue to Challenge Patients and Healthcare Providers
10. Cardium Presents at Tenth Annual Wound Healing: Science and Industry Conference on Matrix Wound Healing Clinical Development
11. Cardium Files FDA 510(k) Application for U.S. Marketing Clearance of ExcellagenXL(TM) Topical Gel and ExcellagenFX(TM) Flowable Collagen Protein-Based Matrix for Diabetic, Pressure and Venous Ulcers and Other Dermal Wounds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... Pa. , Sept. 1, 2015 ... fully integrated specialty pharmaceutical company focused on discovering, ... that researchers will be  presenting scientific data on ... an abuse-deterrent, extended-release, oral morphine product candidate, and ... development, at PainWeek 2015 to be ...
(Date:9/1/2015)... - The ... egistry data presented at ESC Congress 2015 ... the evolution of manag ing AF in everyday ...   The first-ever two-year outcomes from the Global Anticoagulant Registry ... that all-cause death was the most frequent major event in more than 17,000 ...
(Date:9/1/2015)... Calif. , Sept. 1, 2015 /PRNewswire/ ... cardiovascular image management market, Frost & Sullivan ... 2015 European Frost & Sullivan Award for ... -based PMI has designed innovative and easy-to-use ... deliver precise and reproducible quantitative results for ...
Breaking Medicine Technology:Egalet Announces Scientific Presentations at PainWeek 2015 Meeting 2Egalet Announces Scientific Presentations at PainWeek 2015 Meeting 3Egalet Announces Scientific Presentations at PainWeek 2015 Meeting 4Egalet Announces Scientific Presentations at PainWeek 2015 Meeting 5Egalet Announces Scientific Presentations at PainWeek 2015 Meeting 6Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 2Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 3Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 4Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 5Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 6Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 7Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 8Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 9Frost & Sullivan Applauds Pie Medical Imaging for Highly Innovative Quantitative Software for Cardiovascular Diagnosis 2Frost & Sullivan Applauds Pie Medical Imaging for Highly Innovative Quantitative Software for Cardiovascular Diagnosis 3Frost & Sullivan Applauds Pie Medical Imaging for Highly Innovative Quantitative Software for Cardiovascular Diagnosis 4Frost & Sullivan Applauds Pie Medical Imaging for Highly Innovative Quantitative Software for Cardiovascular Diagnosis 5
... organizer UBM Live announced strong booking levels ... buyers and sellers of high value chemistry. 248 exhibitors ... takes place from February 19th to 22nd of 2013 ... fine and specialty chemical companies that have signed up ...
... 15, 2012  Adamas Pharmaceuticals, Inc., a privately held ... End-of-Phase 2 meeting with the FDA to discuss ... conducted for the registration of Arimenda (memantine HCl ... once-daily fixed dose combination of extended release memantine ...
Cached Medicine Technology:Strong Booking Levels For Informex 2013 2Strong Booking Levels For Informex 2013 3Adamas Pharmaceuticals Announces Successful End-of-Phase 2 Meeting with FDA for Arimenda™ 2Adamas Pharmaceuticals Announces Successful End-of-Phase 2 Meeting with FDA for Arimenda™ 3
(Date:9/1/2015)... ... September 01, 2015 , ... ... Nurse Scholar-in Residence at the Institute of Medicine (IOM) of the National Academies. ... at Columbia University School of Nursing. A member of the Institute of Medicine ...
(Date:9/1/2015)... ... September 01, 2015 , ... USA Medical Card, a leading ... to coincide with back-to-school and the start of “sick season” for many households ... school children are sick an average of 8 to 12 times each school ...
(Date:9/1/2015)... ... September 01, 2015 , ... ... Recovery Network, the Premier Outcomes-Driven Provider Network. It is the first-ever, standardized, ... to the provision of quality addiction treatment and the utilization of resources ...
(Date:9/1/2015)... Buffalo, New York (PRWEB) , ... September 01, 2015 , ... ... as one of the Super Lawyers 2015 for his third consecutive year in a ... his achievements and accomplishments of helping people. , Born in Niagara Falls, New York, ...
(Date:9/1/2015)... ... September 01, 2015 , ... Specialty Technical Publishers (STP) ... Audit Protocol Consortium (IAPC) EHS audit protocol for the European Union. Leading companies ... their EHS regulatory obligations and rapidly collect, share, archive, and export audit findings ...
Breaking Medicine News(10 mins):Health News:Columbia Nursing’s Suzanne Bakken Named Distinguished Institute of Medicine Nurse Scholar-in-Residence 2Health News:USA Medical Card Launches New FAQ Video During Back-to-School 2Health News:MAP Health Management Launches the MAP Recovery Network 2Health News:Specialty Technical Publishers (STP) and Specialty Technical Consultants(STC) Publish Environmental, Health & Safety (EHS) Audit Protocol for the European Union 2Health News:Specialty Technical Publishers (STP) and Specialty Technical Consultants(STC) Publish Environmental, Health & Safety (EHS) Audit Protocol for the European Union 3Health News:Specialty Technical Publishers (STP) and Specialty Technical Consultants(STC) Publish Environmental, Health & Safety (EHS) Audit Protocol for the European Union 4
... 10 ThirdForce, the UK,s leading,e-learning provider, now acts as ... care home companies in the UK, Barchester Healthcare.,ThirdForce will support ... Barchester,s quality provision of care and customer,service. , ... the success of the,Barchester business; a group that currently cares ...
... bacteria,s structure, , WEDNESDAY, June 10 (HealthDay News) -- ... a vacation. , Now, researchers have figured out how ... coli, or ETEC -- are able to make ... or "fimbriae" to attach, or bind, to the intestinal ...
... billion kilograms of toxic pollutant releases and transfers reported ... just 30 substances from 15 industrial sectors across the ... tri-national pollution report from the Commission for Environmental Cooperation ... most complete picture of pollution reporting from North American ...
... to teenagers after their sixteenth birthdays and French children ... U.S. parents who follow this relaxed European example, believing ... careful -- it may increase the likelihood that their ... Abar, graduate student, human development and family studies and ...
... Can $167 million in provincial funding make a difference ... results from the Systems Enhancement Evaluation Initiative (SEEI), the ... appropriate community mental health services. But, the research also ... in need. Led by the Centre for ...
... diagnosed in the late and irreversible stages, when treatment ... progression of disease. Because osteoarthritis is a widespread problem ... a precise way to diagnose the disease early and ... biomarkers in dogs for early diagnosis of osteoarthritis, which ...
Cached Medicine News:Health News:Barchester Healthcare Gains Skills for Life With ThirdForce 2Health News:Barchester Healthcare Gains Skills for Life With ThirdForce 3Health News:Finding May Lead to Vaccine for Traveler's Diarrhea 2Health News:Latest trinational report presents most complete picture of North American industrial pollution 2Health News:Latest trinational report presents most complete picture of North American industrial pollution 3Health News:Zero tolerance alcohol policy good choice for parents 2Health News:Evaluation shows $167 million investment improves community mental health system, but many still in need 2Health News:Early detection of osteoarthritis in dogs could open doors for a cure 2
... All Infectious Disease ELISA ... well format. Also included ... positive and negative controls, ... stop solution. Use an ...
InBios' Trypanosoma cruzi (chagas disease) is an ELISA system for the detection of antibodies to T.cruzi derived TcF antigen in human serum or plasma This test is intended for professional in vitro d...
... chain reaction (PCR) technology, the worlds leading ... component of Roches blood screening assays and ... of selected unique regions of genetic material ... (that is, to detectable levels) in only ...
The OneTouch Flexx Professional Blood Glucose Monitoring System with OneTouchPro Test Strips sets the standard for safety and convenience with unique off-meter sample application and a wide range of ...
Medicine Products: