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Cardium Announces New Research Findings: Excellagen Product Candidate Activates Platelet Release of PDGF, an Important Growth Factor Fundamental to the Wound Healing Process
Date:10/13/2010

tive control, Excellagen (2.6% formulated bovine type I collagen) was tested for its ability to activate platelets.

New Preclinical Study and Clinical Implications

For these supplemental studies, the release of PDGF-AB was measured using an Enzyme-Linked Immunosorbent Assay (ELISA).  Data from this study now confirm that Excellagen combined with human platelet concentrate results in clot formation and platelet activation. At 24 hours after clot initiation, comparable levels of released PDGF-AB (~10 ng/mL) were detected in the thrombin- and Excellagen-induced clots. By 48 hours, measurable PDGF-AB was still detectable in the thrombin samples, whereas Excellagen samples had returned to baseline (negative control level).  

The Excellagen product candidate is believed to have several attributes beneficial to the promotion of wound healing, including providing binding sites for growth factors (e.g. PDGF-BB) and a scaffold for migration of cells responsible for generation of granulation tissue. The current findings add to this repertoire of attributes and are consistent with a role of platelet activation and the release of growth factors for 24-48 hours immediately following application of Excellagen to newly-debrided wounds.

Based on the Matrix Phase 2b study protocol, treatment with Excellagen was limited to one application or a second application (if the wound had not healed) four weeks following the initial treatment during the 12 week study period.  Data from this study indicated that the Excellagen product candidate was safe and well-tolerated by all patients receiving one or two treatments.  Based on this safety data and the immediate acceleration of healing, the Company believes that the treatment response observed in the Matrix study offers the potential to be further amplified and sustained in actual clinical practice through multiple treatments with increased frequency.  Cardium's Excellagen fo
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SOURCE Cardium Therapeutics
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