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Cardium Announces New Research Findings: Excellagen Product Candidate Activates Platelet Release of PDGF, an Important Growth Factor Fundamental to the Wound Healing Process
Date:10/13/2010

t, and researchers believe that the interplay of Cardium's formulated collagen with platelets triggers the release of endogenous PDGF and potentially other growth factors, and that this effect may be a significant contributing factor promoting the immediate accelerated wound healing observed in the Matrix study.  

Background

In Cardium's controlled, double blind Matrix Phase 2b clinical study of chronic diabetic lower extremity ulcers, wounds treated with the Excellagen formulated collagen product candidate showed a statistically significant acceleration of wound healing during the first week following a one-time application compared to patients receiving standard of care therapy, a response that was sustained over a 14 day period.  In accordance with the study protocol, wounds were debrided prior to application of Excellagen, thus removing necrotic tissue and wound debris and causing an influx of blood (including platelets) into the wound bed. In light of the immediate and rapid healing response following Excellagen application, it was reasoned that localized platelet activation by Excellagen formulated collagen and the corresponding release of a cascade of endogenous growth factors at the wound site may  be a  contributing factor to the early accelerated healing response observed in the study.    

Generally, platelet activation results in the release of an array of cytokines and growth factors including platelet-derived growth factors (PDGF), vascular endothelial growth factors (VEGF), and transforming growth factor-Beta (TGF-Beta) which are essential for the initiation and progression of the wound healing process.  Activation of platelets can be replicated in vitro by combining bovine thrombin and human platelet concentrate with resultant clot formation and secretion of growth factors into the surrounding media. Using bovine thrombin as a positive control, and buffered saline as a nega
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SOURCE Cardium Therapeutics
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