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Cardioxyl Pharmaceuticals Presents Data On Its Clinical Candidate, CXL-1020, at the 60th Annual American College of Cardiology Scientific Session
Date:4/4/2011

a clinical-stage pharmaceutical company focused on the discovery and development of new classes of safe and effective therapeutic agents for the treatment of cardiovascular disease. Cardioxyl has developed industry-leading expertise in the chemistry, biology and clinical applications of nitroxyl (HNO) technology. The company's core HNO platform has generated several pre-clinical and clinical candidates, including the company's lead compound, CXL-1020, currently in clinical development for ADHF. Cardioxyl is a privately held company financed by life science venture investors, including the Aurora Funds and New Enterprise Associates.

Editor's Note

About Acute Decompensated Heart Failure (ADHF) & Current Treatment Options

ADHF is the leading diagnosis at the time of discharge from U.S. hospitals and the most common cause of hospitalization for patients over 65 years of age.(i) Well over $39 billion was spent in the U.S. in 2009 for the medical care of heart failure patients. ADHF is a deadly condition, with in-hospital mortality rates of two to six percent and six-month readmission rates as high as 30 to 60 percent.  Episodes of ADHF are marked by a severe reduction of cardiac function that typically results in fluid accumulation in the lungs (pulmonary edema) and consequent severe shortness of breath.  There were 1.1 million hospitalizations for acute heart failure in the U.S. in 2006.  Among patients hospitalized with ADHF, the 30-day mortality rate is approximately 11 percent and the one-year mortality rate is 34 percent.  These poor outcomes indicate the clear need for better therapies to treat this patient population.

Despite the severity of the condition, the treatment options available for patients with ADHF remain limited.  Current first-line treatments target the removal of excess fluid (diuresis) and preload and afterload reduction (vasodilation).  In order to improve the hemodynamic
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SOURCE Cardioxyl Pharmaceuticals, Inc.
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