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Cardioxyl Pharmaceuticals Presents Data On Its Clinical Candidate, CXL-1020, at the 60th Annual American College of Cardiology Scientific Session
Date:4/4/2011

d unchanged in the urine within 24 hours post-dose.  At the highest dose (30 microgram/kg/min), 33 percent of patients met a pre-specified criterion for termination of treatment due to a fall in systolic blood pressure of greater than or equal to 20 millimeters of mercury. No severe adverse events were observed.

Doug Cowart, Pharm D., FABCP, RAC, Cardioxyl's Executive Vice President, Development and Regulatory Affairs, said, "These initial clinical results are consistent with our preclinical studies and support that CXL-1020 has  a predictable pharmacokinetic profile, an acceptable safety profile and appears to be well tolerated by patients."

About CXL-1020

Cardioxyl has developed a nitroxyl chemistry platform technology that serves as the foundation for the company's drug discovery efforts. In research published by Cardioxyl's scientific founders from Johns Hopkins University, nitroxyl was shown to have positive vasodilatory and direct myocardial effects.  CXL-1020, a proprietary nitroxyl donor, is Cardioxyl's lead compound for the intravenous treatment of acute decompensated heart failure (ADHF).  A prodrug, CXL-1020 once administered, chemically converts into an active nitroxyl (HNO) compound and an organic byproduct.   In pre-clinical models of heart failure, CXL-1020 improves cardiovascular performance by enhancing the contractility (inotropy) and relaxation (lusitropy) of the failing heart and dilating the peripheral vasculature (vasodilation), without increasing heart rate or myocardial oxygen consumption.  Cardioxyl completed a Phase I/IIa safety and dose-escalation study of CXL-1020 in stable chronic heart failure subjects and has announced initiation of a Phase IIa trial. Based on all pre-clinical studies to date, CXL-1020 is anticipated to improve the symptoms, hemodynamics and clinical status of patients with ADHF.

About Cardioxyl Pharmaceuticals

Cardioxyl Pharmaceuticals is
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SOURCE Cardioxyl Pharmaceuticals, Inc.
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