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Cardioxyl Pharmaceuticals Presents Data On Its Clinical Candidate, CXL-1020, at the 60th Annual American College of Cardiology Scientific Session
Date:4/4/2011

NEW ORLEANS and CHAPEL HILL, N.C., April 4, 2011 /PRNewswire/ -- Cardioxyl Pharmaceuticals, Inc. announced today that it is presenting two abstracts from studies of its lead clinical candidate, CXL-1020, at the American College of Cardiology's (ACC) 60th Annual Scientific Session & Expo in New Orleans, Louisiana. Preclinical results highlighted in the first abstract demonstrate CXL-1020's ability to work independently from other heart failure therapies, furthering important insights into the cellular mechanism of action of nitroxyl donors. Clinical results presented in the second abstract demonstrate, for the first time, CXL-1020's safety and tolerability in people who have stable congestive heart failure (CHF), a good predictor of safety in people with acute decompensated heart failure (ADHF).  

"Today's research findings provide additional support for the unique mechanism of CXL-1020 and for its strong safety profile and tolerability in patients with stable CHF," said Chris Kroeger, M.D., President and Chief Executive Officer.  "We are currently enrolling a Phase IIa clinical trial to further define safety, tolerability and dosing for CXL-1020 in patients with ADHF, bringing us closer to making this treatment a reality for the millions who suffer from this disease."  

Following are the details of the data presented at ACC Poster Sessions:

CXL-1020, a Novel HNO Donor, Decreases Myocardial Loading and Enhances Load-Independent Lusitropy and Inotropy via a Beta-AR/ACE Independent Mechanism. Monday, April 4, 2011; 1:45 p.m. – 4:45 p.m., Ernest N. Morial Convention Center, Hall F; Poster Board #21

In this preclinical study, Cardioxyl and QTest Labs researchers compared the hemodynamic profile of CXL-1020 with the vasodilator, sodium nitroprusside (SNP).  The results show that under conditions of matched reduction of systolic pressure, CXL-1020 and SNP increased stroke volume without incre
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SOURCE Cardioxyl Pharmaceuticals, Inc.
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