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Cardioxyl Pharmaceuticals Initiates Dose-Defining Phase IIa Study of Its Lead Candidate, CXL-1020, in Heart Failure Patients
Date:8/26/2010

atabase of safety information for CXL-1020. Further information on this trial can be found at www.clinicaltrials.gov at reference number NCT01096043.

Juan Aranda, M.D., Professor of Medicine, Director of Cardiac Transplantation at The University of Florida, Gainesville, who is an investigator in the Phase IIa study commented, "Based on Phase I/IIa clinical results with CXL-1020, we have reason to believe this cardiovascular drug will be an important new option in the treatment of patients with ADHF. This Phase IIa study will provide additional valuable insight into the potential benefits of CXL-1020 for these seriously ill patients."

About CXL-1020Cardioxyl has developed a nitroxyl chemistry platform technology that serves as the foundation for the company's drug discovery efforts. In research published by Cardioxyl's scientific founders from Johns Hopkins University, nitroxyl was shown to have positive vasodilatory and direct myocardial effects.  CXL-1020, a proprietary nitroxyl donor, is Cardioxyl's lead compound for the intravenous treatment of acute decompensated heart failure (ADHF).  In pre-clinical models of heart failure, CXL-1020 improves cardiovascular performance by enhancing the contractility (inotropy) and relaxation (lusitropy) of the failing heart and dilating the peripheral vasculature (vasodilation), without increasing heart rate or myocardial oxygen consumption.  Cardioxyl completed a Phase I/IIa safety and dose-escalation study of CXL-1020 in stable chronic heart failure subjects and has announced initiation of a Phase IIa trial. Based on all pre-clinical studies to date, CXL-1020 is anticipated to improve the symptoms, hemodynamics and clinical status of patients with ADHF.  

About Acute Decompensated Heart Failure (ADHF) & Current T
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SOURCE Cardioxyl Pharmaceuticals, Inc.
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