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Cardiovascular Drug Delivery - Technologies, Markets and Companies
Date:11/30/2011

Stenosis associated with stents 115

Absorbable metal stents 115

Drug-eluting stents 115

Various types of DES 116

CYPHER® sirolimus-eluting coronary stent 116

Dexamethasone-eluting stents 116

NO-generating stents 117

Paclitaxel-eluting stents 117

Sirolimus-eluting vs paclitaxel-eluting stents 118

Novel technologies for DES 118

Absorbable DES 118

Bio-absorbable low-dose DES 119

Drug-eluting stents coated with polymer surfaces 119

Endeavour DES 119

Stents for delivery of gene therapy 120

Stem cell-based stents 121

VAN 10-4 DES 121

Nanotechnology-based stents 122

Drugs encapsulated in biodegradable nanoparticles 122

Magnetic nanoparticle-coated DES 122

Magnetic nanoparticles encapsulating paclitaxel targeted to stents 123

Nanocoated DES 123

Nanopores to enhance compatibility of DES 124

The ideal DES 124

Companies developing drug-eluting stents 124

Clinical trials of drug-eluting stents 125

Measurements used in clinical trials of DES 125

TAXUS paclitaxel-eluting stents 126

XIENCE™ V everolimus-eluting coronary stent 127

COSTAR II clinical trial 127

Endeavor RESOLUTE zotarolimus-eluting stent system 128

CUSTOM I clinical trial 128

NOBORI CORE Trial 129

LEADERS trial 129

Comparison of DES in clinical trials 130

Comparison of DES with competing technologies 130

DES versus coronary artery bypass graft 130

DES versus bare metal stents 131

Guidelines for DES vs BMS 133

DES vs BMS for off-label indications 133

Role of DES in cases of bare-metal in-stent restenosis 134

DES versus balloon catheter coated with paclitaxel 134

DES versus intracoronary radiation therapy for recurrent stenosis 134

Cost-effectiveness of DES 135

Safety issues of DES 136

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