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CardioMind Launches First-in-Human Trial of Small Vessel, Drug-Eluting Stent
Date:3/31/2008

o offers more flexibility than current stents, making it especially adaptable to treatment of the small, tortuous blood vessels often associated with diabetes.

To coat the Sparrow stent, CardioMind has licensed the rights to the SynBiosys(TM) biodegradable polymer system from SurModics, Inc. (Nasdaq: SRDX). "The SynBiosys polymer allows the Sparrow stent to gradually return to a bare metal state, where we as an industry have 15 years of data showing no increase in late stent thrombosis," says Maroney.

Clinical Trials

The multi-site CARE II study, which will eventually enroll 220 patients, is a randomized trial of three different stents -- both bare-metal and drug-eluting versions of the Sparrow, plus a competitive stent.

According to Dr. Robert Whitbourn, associate professor and director of the Cardiovascular Research Center at St. Vincent's Hospital and one of the study's lead investigators: "Thus far, the first cases in this study are very encouraging. All our implanted patients are doing well, and I am impressed with the overall deliverability and performance of this new stent delivery system." Dr. Whitbourn expects to report first full follow-up results in eight months.

Overall, says Dr. Whitbourn, "The CardioMind Sparrow System represents a promising technology in interventional cardiology. The concept of a true guidewire-delivered stent opens up the possibilities of stenting in small vessels, branch vessels and other difficult-to-access vessels. It could, thus, expand the types of lesions in coronary artery disease that can be treated in more difficult patient populations."

Venture Funding

By reaching its First-in-Human milestone, CardioMind triggered the second tranche closing of a $33-million venture capital round raised in June 2007. That round, CardioMind's third since it was founded in 2003, included an initial $11-million for research and development and the just-released $22-million for completion of the
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SOURCE CardioMind, Inc.
Copyright©2008 PR Newswire.
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