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Cardiac Dimensions® Announces Presentation of 12-Month Follow-up Data of TITAN™ Trial at European Society of Cardiology Meeting
Date:8/18/2010

ix month) data revealed a 68 percent implant rate for the TITAN™ trial.  An important feature of the CARILLON® device is the ability to be recaptured, if necessary, peri-procedurally.  Fifteen percent of patients were not implanted because of transient coronary occlusion observed during the procedure allowing the device to be safely removed.  The device was also recaptured if significant FMR reduction could not be confirmed at the time of the procedure. There was one peri-procedural contrast related death in a non-implanted patient resulting in a 1.9 percent one month MAE rate.  Acute peri-procedural FMR reduction was confirmed by the echo core lab at 1 month.  By six months, the average reduction among four quantitative echo measures of FMR was 35 percent.  These hemodynamic results corresponded with an improvement in six-minute walk distance of greater than 100 meters and a one grade reduction in the NYHA class at six months in the implanted patient cohort.  

About the CARILLON® Mitral Contour SystemThe investigational CARILLON® Mitral Contour System™ combines a proprietary implantable device and delivery system. The implant consists of a shaping ribbon between distal and proximal anchors. It is delivered percutaneously via jugular vein access under fluoroscopic guidance. The implant is designed to be positioned, adjusted and gently anchored in the coronary sinus/great cardiac vein to reshape the annulus around the mitral valve, thereby reducing mitral regurgitation. Multiple clinical studies have shown that the reduction in mitral regurgitation is associated with improvements in other key functional parameters including NYHA class, 6 Minute Walk distances, and Quality of Life.

About Cardiac Dimensions®, Inc.Cardiac Dimensions, based in Kirkland, Washington, develops and manufactures devices designed for treating functional mitral regurgitation, heart failure and related condit
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SOURCE Cardiac Dimensions, Inc.
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