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Carbylan BioSurgery Completes Enrollment in Key Clinical Feasibility Study of Hydros and Hydros TA in Patients With Pain From Knee Osteoarthritis; Core Patent Issued
Date:1/5/2011

on November 9, 2010 the US Patent Office issued a key Carbylan patent covering novel modified hyaluronic acid polymer compositions and methods (US Pat. 7,829,118). This patent protects the composition of matter for Hydros and Hydros TA as well as the proprietary chemistry used to trap the steroidal suspension inside the hydrogel component for Hydros TA from generic competition until 2030.

About Hydros and Hydros TA Joint Therapies

Hydros Joint Therapy ("Hydros") is an intra-articular injection therapy comprised of non-animal sourced hyaluronic acid (HA) which is chemically modified to form hydrogel beads.   Hydros is biodegradable and resides in the joint for up to thirty days and is expected to provide sustained pain relief for up to six months with a single injection. Traditional viscosupplements are cleared from the joint in less than a week.  Hydros TA Joint Therapy ("Hydros TA") is a novel dual mode viscosupplement which traps 10mg of triamcinolone acetonide (corticosteroid) inside the Hydros hydrogel beads. Hydros TA is expected to provide faster acting, longer lasting pain relief than either viscosupplements or steroids alone.  Hydros TA allows for sustained local delivery of a low dose steroid reducing the risk of systemic steroid exposure and the potential cartilage degradation associated with steroid injections in the knee.  There is currently no similar viscosupplement/steroid combination product available to treat the pain associated with osteoarthritis.  

About Osteoarthritis

Osteoarthritis (OA), also known as degenerative arthritis or degenerative joint disease, is a group of mechanical abnormalities involving degradation of joints.   Knee osteoarthritis is the most common type of osteoarthritis. More than 10 million Americans have knee osteoarthritis. It is also the most common cause of disability in the United States.

About Carbylan BioSurgery

Carbylan was founded in 2005 to deve
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SOURCE Carbylan BioSurgery, Inc.
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