Navigation Links
Cara Therapeutics Initiates Phase 1 Clinical Trial of Novel Analgesic, CR845
Date:4/28/2008

SHELTON, Conn., April 28 /PRNewswire/ -- Cara Therapeutics, Inc. today announced that it has initiated a Phase 1 clinical trial of its long-acting peripheral kappa opioid receptor agonist, CR845. The Phase 1a single-center clinical trial will evaluate the safety, tolerability, pharmacokinetic profile, and pharmacological activity of CR845 in a double-blind, randomized, placebo-controlled, single escalating intravenous dose study in 58 healthy male and female volunteers.

The company is also developing oral and subcutaneous formulations of CR845.

About CR845

In preclinical studies, CR845 was highly selective for the peripheral kappa opioid receptor. Animal studies indicate that CR845 is effective in treating pain of inflammatory, neuropathic and visceral origin and exhibits analgesic efficacy for up to 18 hours after a single dose. Analgesic activity was seen after intravenous, subcutaneous, or oral administration. Unlike currently marketed opioids, CR845 did not inhibit intestinal transit (ileus) or elicit signs of addiction in animal models. Preclinical studies also indicate that CR845 possesses anti-itch activity.

About Cara Therapeutics

Cara Therapeutics is a privately held biotechnology company focused on developing novel, superior therapeutics to treat pain and inflammation associated with diverse medical conditions. Cara's current pipeline includes near-term clinical drug candidates identified as mechanistically distinct, peripherally-acting analgesics.

Forward-Looking Statements

Certain statements in this press release are forward-looking statements that involve a number of risks and uncertainties. Such forward-looking statements include statements relating to the therapeutic applications of CR845 and about Cara's strategy, technologies, pre-clinical and clinical programs, and ability to identify and develop drugs, as well as other statements that are not historical facts. Actual events or results may dif
'/>"/>

SOURCE Cara Therapeutics, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. PTC Therapeutics Announces Initiation of Phase 2b Registration-Directed Clinical Trial of PTC124 in Duchenne/Becker Muscular Dystrophy
2. Halozyme Therapeutics Presents Findings on Combinations of rHuPH20 Enzyme With Bisphosphonates at the American Association for Cancer Research Conference
3. Halozyme Therapeutics Presents Pre-Clinical Studies of Systemic Delivery of Pegylated rHuPH20 Enyzme in Prostate Cancer Models at American Association for Cancer Research Conference
4. Nektar Therapeutics to Present Positive Data at Upcoming Medical and Scientific Meetings
5. Echo Therapeutics Announces Positive Results with the Prelude(TM) SkinPrep System, the Next-Generation Skin Permeation Medium for its Symphony(TM) Transdermal Continuous Glucose Monitoring System
6. Recent siRNA Research Publications Support Silence Therapeutics Combined Development Approach
7. European Regulatory Agency Accepts Cell Therapeutics, Inc.s Marketing Authorization Application for XYOTAX(TM) for Lung Cancer for Review
8. CV Therapeutics Anti-Ischemic Therapy Ranexa(R) Significantly Reduces Cardiac Chest Pain Symptoms and Recurrent Ischemia in MERLIN-TIMI 36 Patients With Angina
9. Michael J. Fox Foundation Commits up to $10 Million for Pre-Clinical Drug Development Under Therapeutics Development Initiative
10. Synvista Therapeutics Presents New Preclinical Data Demonstrating the Value of Haptoglobin Genotype Testing In Diabetes at ACC Scientific Sessions
11. Cell Therapeutics, Inc. (CTI) Announces Enrollment Complete in Phase III EXTEND (PIX301) Clinical Trial of Pixantrone in Patients With Second or Greater Relapse of Diffuse Large B Cell NHL
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)...  Decision Resources Group finds that over ... currently treated with Biogen Idec,s oral disease-modify ... and/or gastrointestinal events while on the therapy. ... these side effects, signifying either their transient ... such events. In the end, fewer than ...
(Date:7/22/2014)... 22, 2014 BiologicTx ® today announced ... 3-way Kidney Paired Donation transplant exchange utilizing BiologicTx,s proprietary ... July 9 at the Miami Transplant Institute, located at ... Kidney Paired Donation (KPD) is ... for kidney transplant with one another due to incompatible ...
(Date:7/22/2014)... Wis. , July 22, 2014  PuraMed ... marketer of over-the-counter (OTC) medicinal and healthcare products, ... sponsor of Operation Troop Aid. "We ... Russell Mitchell , CEO and Chairman of ... and women in combat zones experience migraines much ...
Breaking Medicine Technology:Over Half of Audited Multiple Sclerosis Patients Currently Treated with Biogen Idec's Tecfidera Have Experienced Minor Side Effects Although Impact on Use Appears Muted 2Over Half of Audited Multiple Sclerosis Patients Currently Treated with Biogen Idec's Tecfidera Have Experienced Minor Side Effects Although Impact on Use Appears Muted 3BiologicTx Paired Donation Aids In Successful Kidney Transplants 2BiologicTx Paired Donation Aids In Successful Kidney Transplants 3PuraMed BioScience Partners with Operation Troop Aid to Sponsor Care Packages 2PuraMed BioScience Partners with Operation Troop Aid to Sponsor Care Packages 3
... Eli Lilly and Company (NYSE: LLY ) ... cost-effectiveness of insulin lispro mix 75/25 and insulin lispro mix ... analysis indicated that for patients with type 2 diabetes who ... are likely to be cost-effective when compared to LAIA in ...
... Sanofi (EURONEXT: SAN and NYSE: SNY ... once-daily GLP-1 receptor agonist Lyxumia® (lixisenatide) that  is in ... results in type 2 diabetes patients not at goal ... are being presented or published at the American Diabetes ...
Cached Medicine Technology:Analysis Compares Cost-Effectiveness of Premixed Insulin Analogs to Long-Acting Insulin Analogs in the Long-Term Treatment of Type 2 Diabetes in the U.S. 2Analysis Compares Cost-Effectiveness of Premixed Insulin Analogs to Long-Acting Insulin Analogs in the Long-Term Treatment of Type 2 Diabetes in the U.S. 3Analysis Compares Cost-Effectiveness of Premixed Insulin Analogs to Long-Acting Insulin Analogs in the Long-Term Treatment of Type 2 Diabetes in the U.S. 4Analysis Compares Cost-Effectiveness of Premixed Insulin Analogs to Long-Acting Insulin Analogs in the Long-Term Treatment of Type 2 Diabetes in the U.S. 5Analysis Compares Cost-Effectiveness of Premixed Insulin Analogs to Long-Acting Insulin Analogs in the Long-Term Treatment of Type 2 Diabetes in the U.S. 6Analysis Compares Cost-Effectiveness of Premixed Insulin Analogs to Long-Acting Insulin Analogs in the Long-Term Treatment of Type 2 Diabetes in the U.S. 7Positive Results for Investigational Compound Lyxumia® (Lixisenatide) Presented at American Diabetes Association's 71st Annual Scientific Sessions 2Positive Results for Investigational Compound Lyxumia® (Lixisenatide) Presented at American Diabetes Association's 71st Annual Scientific Sessions 3Positive Results for Investigational Compound Lyxumia® (Lixisenatide) Presented at American Diabetes Association's 71st Annual Scientific Sessions 4Positive Results for Investigational Compound Lyxumia® (Lixisenatide) Presented at American Diabetes Association's 71st Annual Scientific Sessions 5Positive Results for Investigational Compound Lyxumia® (Lixisenatide) Presented at American Diabetes Association's 71st Annual Scientific Sessions 6Positive Results for Investigational Compound Lyxumia® (Lixisenatide) Presented at American Diabetes Association's 71st Annual Scientific Sessions 7Positive Results for Investigational Compound Lyxumia® (Lixisenatide) Presented at American Diabetes Association's 71st Annual Scientific Sessions 8
(Date:7/22/2014)... Washington, DC (PRWEB) July 22, 2014 Ticket ... vs. Inter Milan tickets at Fedex Field in Landover, MD. ... Sates to be a fan of international soccer. After the success ... in Brazil, soccer fever is alive and well. One way that ... hunger for the sport is with the 2014 Guinness International Champions ...
(Date:7/22/2014)... 2014 The park is the heart ... Kendalltown Homeowners Association, Inc., made a recent investment ... with the purchase of playground equipment from American Parks ... beautiful Miami Florida, and is a 475-unit community that ... surrounding landscape has created a tropical paradise with lush ...
(Date:7/22/2014)... By Kathleen Doheny ... -- Removing the uterus with a minimally invasive procedure known ... now a new study pinpoints the likelihood more clearly. ... undetected uterine cancer at the time of the procedure, researchers ... age of 65. Surgeons performing a hysterectomy with morcellation ...
(Date:7/22/2014)... (PRWEB) July 22, 2014 CarePoint Health is ... elected as the President of the medical staff at Bayonne ... will serve as President, as voted on by the physicians ... the medical staff in relation to the administration at Bayonne ... of physicians and to work to make the Medical Center ...
(Date:7/22/2014)... Latin America Drilling fluid and Completion fluid Market Report defines ... Latin America with analysis and forecast of revenue. The drilling ... to grow from around $0.93 billion in 2013 to $1.45 ... given period. , Browse through the TOC of the Latin ... an idea of the in-depth analysis provided. This also provides ...
Breaking Medicine News(10 mins):Health News:Manchester United vs. Inter Milan Tickets Fedex Field Landover: Ticket Down Slashes Ticket Prices for Inter Milan ManU International Champions Cup Match in Washington, DC 2Health News:Manchester United vs. Inter Milan Tickets Fedex Field Landover: Ticket Down Slashes Ticket Prices for Inter Milan ManU International Champions Cup Match in Washington, DC 3Health News:Fun in the Florida Sun: Kendalltown Homeowners Association Inc. Expands Outdoor Recreation with American Parks Company™ 2Health News:Fun in the Florida Sun: Kendalltown Homeowners Association Inc. Expands Outdoor Recreation with American Parks Company™ 3Health News:Technique Used in Some Hysterectomies May Help Spread Cancer: Study 2Health News:Technique Used in Some Hysterectomies May Help Spread Cancer: Study 3Health News:Dr. Howard Levine Elected President of the Medical Staff at Bayonne Medical Center 2Health News:Latin America Drilling Fluid & Completion Fluid Market is Expected to Reach $1.45 Billion in 2018 - New Report by MicroMarket Monitor 2Health News:Latin America Drilling Fluid & Completion Fluid Market is Expected to Reach $1.45 Billion in 2018 - New Report by MicroMarket Monitor 3Health News:Latin America Drilling Fluid & Completion Fluid Market is Expected to Reach $1.45 Billion in 2018 - New Report by MicroMarket Monitor 4Health News:Latin America Drilling Fluid & Completion Fluid Market is Expected to Reach $1.45 Billion in 2018 - New Report by MicroMarket Monitor 5Health News:Latin America Drilling Fluid & Completion Fluid Market is Expected to Reach $1.45 Billion in 2018 - New Report by MicroMarket Monitor 6
... 59 feet-long articulated vehicle using the latest satellite technology developed ... year.// ,The unit will conduct the high-speed transfer of ... Cancer. Besides this, health check ups for men and support ... first of its kind in Europe. ,According to Action ...
... most rural counties of the United States are hospitalized ... //by HHS Agency for Healthcare Research and Quality and ... Ambulatory Pediatrics. ,The study, which was led by ... of health care, health status, and other measures for ...
... organization, National Dairy Development Board (NDDB), is like the ... rolled out its batch of DNA Hepatitis –B Vaccine//, ... compared to the other brands in the market. ... at its facility in Gachibowli, will be sold under ...
... Alcohol consumption has been linked with violence and increased homicide ... increased, there has been a decrease in the number of ... has brought done the violence as well as homicide, a ... October issue of Alcoholism: Clinical & Experimental Research. ...
... endeavour to run 24-half marathons in 24 consecutive days will ... also give// publicity to his employer. ,Young ran ... and took another step towards the noble cause. ... supported me in my endeavour to raise 100,000 pounds for ...
... Pradesh may raise the retirement age of medical specialists and ... order to provide due healthcare to people. , ,"Providing ... of the state government and for this the government will ... needed, special allowance will also be provided to them," Chief ...
Cached Medicine News:Health News:Big Bus, the ?1.5m Cancer Bus Hits the roa 2Health News:Local Health Care Limited for Rural Children 2Health News:Alcoholics Anonymous: A Blessing For The Addicted 2Health News:Alcoholics Anonymous: A Blessing For The Addicted 3Health News:Cancer Survivor Runs Half-marathon 2
ACMI™ COAG Bipolar Laparoscopy Probes provide 360 of hemostatis, bipolar safety, blunt dissection, irrigation, and suction in one instrument....
... An in vitro Nucleic Acid ... using Microplate Chemiluminescence for the ... (HPV) Types 6,11,16,18,31,33,35,39,42,43,44,45,51,52,56,58,59 and 68 ... Lowand High-Risk Groups in Cervical ...
An In Vitro Nucleic Acid Hybridization Assay with Signal Amplification using Microplate Chemiluminescence for the Qualitative Detection of Human Papillomavirus (HPV) Types 16, 18, 31, 33, 35, 39, 45,...
... AS100 Analyzer is designed ... regardless of the sample ... launched in December 2004, ... in May 2005. Assays ...
Medicine Products: