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Cara Therapeutics Announces Appointment of James B. Jones, M.D., Pharm.D., as Chief Medical Officer
Date:3/30/2011

in and chronic pain conditions."

About CR845

CR845 is a highly selective, peripherally restricted kappa opioid receptor agonist currently in Phase 2 clinical development for the treatment of post-operative pain.  A randomized, placebo-controlled Phase 2 study has provided evidence of analgesic efficacy of CR845 administered as a single intravenous dose to women following laparoscopic hysterectomy.  In this study, in addition to decreases in reported pain levels, patients receiving CR845 required substantially lower amounts of post-operative opioids and showed a significant reduction in the incidence of post-operative nausea. Cara recently completed a Phase 1b repeat dose safety study of intravenous CR845 and plans to initiate additional Phase 2 efficacy studies of the drug in 2011. In addition, the Company plans to initiate a phase 1 safety and pharmacokinetic study of an oral capsule formulation of CR845 shortly. More than 140 human subjects have been exposed to CR845 to date.  The safety profile of the drug has been excellent with no cases of dysphoric reactions or hallucinations as seen previously with centrally-acting kappa opioids.  

About Cara Therapeutics

Cara Therapeutics is a privately held biotechnology company focused on developing novel, superior therapeutics to treat pain and inflammation associated with diverse medical conditions. In addition to CR845, Cara's current pipeline includes near-term clinical development candidates within multiple proprietary classes of peripherally restricted cannabinoids with preclinical analgesic and anti-inflammatory activity. Cara also plans to develop entirely novel classes of analgesics that emerge from its proprietary GPCR DimerScreen™ technology.

Forward-Looking Statements

Certain statements in this press release are forward-looking statements that involve a number of risks and uncertainties. Such forward-looking statements include
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SOURCE Cara Therapeutics, Inc.
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