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Cannabis Science announces preclinical development program for CS-TATI-I, commencing EU operations in the Netherlands and sourcing proprietary material for pharmacokinetic characterization
Date:4/26/2013

Dr. Richard Ogden and Dr. Ron Sekura and other prestigious members of the Company's Scientific Advisory Board, has prepared us to initiate preclinical characterization studies that will provide Cannabis Science with the pathway to our first-in-class, first-in-man studies of CS-TATI-I.  By establishing a corporate presence with the Amsterdam Life Science Cluster, the Company is able to aggressively move forward with the research necessary to progress to human trials."

"Initial studies will be followed by investigation of full exposure response curves, enzyme expression, QSAR analysis, in vitro-in vivo extrapolation, optimization of release rates and full exposure response curves, among others," said Roscoe M. Moore, Jr. , DVM, PhD, MPH, Chair of the Company's Scientific Advisory Board. "We are exploring further optimization of semisolid topical and transdermal drug product physiochemical composition, physical performance and delivery of CS-TATI-I via validated methods and procedures in preparation for Phase I trials through the use of electroporation, product quality testing, product performance evaluation and topical dose control dispensement."

Cannabis Science plans to announce the results of these studies at significant conference venues, including HIV DART 2013, 27th International Conference on Antiviral Research (ICAR), 15th International Workshop on the Clinical Pharmacology of HIV Therapy and International Symposium on HIV and Emerging Infectious Diseases (ISHEID 2014).

Peer-reviewed studies validate Cannabis Science's approach to commercializing the antiviral potential of cannabinoid-based therapeutics as a viable target for addressing the Kaposi's Sarcoma-associated herpesvirus (KSHV) and HIV Tat inhibition.  A study published in 2012 by researchers from Harvard Medical School found that cannabidiol (CBD) inhibits t
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