Date:5/29/2012

human health. The endocannabinoid system formally evolved with the appearance of vertebrates, with the development of receptors that specifically bind to the lipid derived endocannabinoids. Surprisingly, the endocannabinoid system is a global, multi-scaled, homeostatic regulator of all body systems. Thus, the cardiovascular, digestive, endocrine, immune, musculoskeletal, nervous, reproductive, and tegumentary systems are all kept in dynamic balance by the endocannabinoid system through its ability to regulate mass and energy flow (the munchies). All cells can only survive by extracting what they need from their environment in order to maintain their internal organization. Cannabinoids, including those derived from the plant (phytocannabinoids), those produced by our bodies (endocannabinoids), and those synthesized by man (synthetics) can very powerfully promote the death of cancer cells by disrupting their internal organization while minimizing the ability of the environment to support them. Thus, unlike conventional pharmaceuticals and anticancer agents that typically target a single pathway (the magic bullet approach), cannabinoids impact many aspects of cellular and organismic biochemistry to kill cancers. The chemical complexity of concentrated cannabis extracts holistically decreases the probability that a cancer cell can survive while at the same time promoting general health, as evidenced by the anti-aging and health promoting properties that arise from stimulating the endocannabinoids system.

Melamede, R. Harm reduction--the cannabis paradox. Harm Reduct J 2, 17 (2005).

Sarfaraz, S., Adhami, V. M., Syed, D. N., Afaq, F. & Mukhtar, H. Cannabinoids for cancer treatment: progress and promise. Cancer Res 68, 339-342 (2008).

Massi, P., Solinas, M., Cinquina, V. & Parolaro, D. CANNABIDIOL AS POTENTIAL ANTICANCER DRUG. Br J Clin Pharmacol (2012).

Hermanson, D. J. & Marnett, L. J. Cannabinoids, endocannabinoids, and cancer
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SOURCE Cannabis Science, Inc. Copyright©2010 PR Newswire. All rights reserved

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