Navigation Links
Cancer Treatment Centers of America(R) Studies Treatment That Aims Chemotherapy Directly at Ovarian Cancer Cells
Date:6/17/2009

Therapy targets folate receptors found on cancer cells otherwise resistant to standard chemo

ZION, Ill., June 17 /PRNewswire-USNewswire/ -- Cancer Treatment Centers of America (CTCA) at Midwestern Regional Medical Center, a leading provider of innovative cancer care for patients living with complex and advanced-stage disease, is the only hospital in Illinois and Wisconsin to take part in new clinical research involving a treatment designed to target ovarian cancer cells otherwise resistant to standard chemotherapy.

(Logo: http://www.newscom.com/cgi-bin/prnh/20090612/CTCALOGO)

The Phase II clinical study, called "PRECEDENT," is designed to evaluate the safety and efficacy of EC145, a drug currently being studied in the treatment for women with ovarian cancer who develop a resistance to standard platinum-based chemotherapy. EC145 was developed by Endocyte, a privately-held biotechnology company.

"With EC145, we're working to target a powerful chemotherapy drug directly to cancer cells while sparing the healthy cells," says Dr. Sybilann Williams, MD, gynecologic oncologist and surgeon at Cancer Treatment Centers of America at Midwestern Regional Medical Center and principal investigator for the PRECEDENT study. "EC145 is designed to target the folate receptors found in high concentrations on cancer cells," she adds.

In order to be eligible for the PRECEDENT study, patients must have platinum-resistant ovarian cancer where the disease has progressed or recurred within six months of a first or second treatment with a platinum-based chemotherapy drug. Those eligible will be treated with Doxil(R) (pegylated liposomal doxorubicin), an approved drug used to treat ovarian cancer, or with EC145, which combines Doxil with folate (vitamin B-9).

The PRECEDENT study is yet another example of CTCA's commitment to expanding medical treatment options for women battling ovarian cancer. In October 2008, CTCA at Midwestern Regional Medical Center announced a ground-breaking clinical trial of an ovarian cancer vaccine called o-Vax that uses cells taken from an individual patient's tumor to stimulate immune cells to attack the existing cancer. Patients continue to be accepted for this clinical trial.

"CTCA offers a powerful combination of traditional and innovative therapies provided by a team of cancer experts who work with each patient individually, to determine the appropriate combination of therapies to fight cancer," Dr. Williams says.

Ovarian cancer is the ninth most common cancer among women, and the leading cause of death due to cancer of the female reproductive system. According to the American Cancer Society, it is estimated that there will be 21,550 new cases of ovarian cancer in the U.S. in 2009 and 14,600 cancer-related deaths. A woman's risk of getting invasive ovarian cancer during her lifetime is about one out of every 71 women.

Patients interested in the clinical trial may contact a CTCA Oncology Information Specialist at 877-98-TRIAL.

About Cancer Treatment Centers of America

Founded in 1988, Cancer Treatment Centers of America (CTCA) provides a comprehensive, patient-centered treatment model that fully integrates traditional, state-of-the-art medical treatments with scientifically-supported complementary and alternative therapies such as nutrition, naturopathy, psychological counseling, physical therapy and spiritual support to meet the special, whole-person needs of advanced-stage cancer patients. With a network of cancer treatment hospitals and community oncology programs in Illinois, Oklahoma, Pennsylvania and Washington, CTCA encourages patients and their families to participate in treatment decisions with its Patient Empowerment Medicine(SM) model. For more information about Cancer Treatment Centers of America, go to www.cancercenter.com.

About Endocyte

Endocyte is a privately-held biotechnology company with headquarters in the Purdue Research Park of West Lafayette, IN. Based on the applications of Endocyte's advanced proprietary Drug Guidance System (DGS), the Company is working to develop new drugs and diagnostic agents to treat many types of cancer and other serious diseases. The DGS platform makes it possible to use highly-potent drugs on extended and frequent dosing schedules and in combination with other drugs to maximize efficacy. The technology improves drug targeting and reduces the risk of side effects by combining drugs with ligands that are able to identify and attach to receptors found on tumor and other disease cells. Endocyte is currently conducting three separate Phase 2 clinical trials for its lead compound, EC145, together with EC20, a companion molecular imaging agent, for the treatment of ovarian cancer and non-small cell lung cancer. Other clinical-stage products in the Endocyte pipeline include: EC0225, a combination of two potent anticancer drugs; BMS493, a potent drug being developed in partnership with Bristol-Myers Squibb; EC17, a targeted immunotherapy agent; and EC0489, a targeted cancer drug. The Company also has multiple product candidates in pre-clinical stage development.


'/>"/>
SOURCE Cancer Treatment Centers of America
Copyright©2009 PR Newswire.
All rights reserved

Related medicine technology :

1. CuraGen Announces Expansion of CR011-vcMMAE Phase II Trial in Advanced Breast Cancer
2. Study Suggests Vitamin D Screening and Appropriate Supplementation Indicated for All Cancer Patients
3. Researchers Say More Aggressive Vitamin D Supplementation Needed in Obese Cancer Patients
4. Jennerex Therapeutic Research Collaboration With Ottawa Hospital Research Institute Selected for $10 Million Grant From Ontario Institute for Cancer Research
5. Heaviest Smokers Face Greatest Risk of Death After Lung Cancer Diagnosis
6. Advance in Bowel Cancer Test Research
7. Investigational Cancer Drug BSI-201 Showed Clinical Benefit in 62% of Patients with Triple-Negative Metastatic Breast Cancer and Significantly Prolonged Survival
8. Peregrine Pharmaceuticals Highlights Promising Early Data From Its Three Phase II Bavituximab Cancer Trials
9. Paclitaxel Poliglumex (OPAXIO(TM)) Added to Cisplatin and Radiation Produces 45% Pathologic Complete Remissions in Patients With Esophageal Cancer
10. Medivation Announces Positive New Efficacy Data From Phase 1-2 Trial of MDV3100 in Advanced Prostate Cancer Patients
11. Researchers at the Karmanos Cancer Institute in Detroit Discover Feasibility of Chemotherapy Alternative
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... -- The primary goal of this research is to ... usage of liquid biopsy. Key information the survey seeks ... of liquid biopsy adoption amidst future users - Predominantly ... - Sample inflow to conduct liquid biopsy tests - ... so on. - Correlation analysis of sample type and ...
(Date:2/11/2016)... SAN FRANCISCO , Feb. 11, 2016  Kindred ... focused on saving and improving the lives of pets, ... Technical Section of the New Animal Drug Application (NADA) ... the pivotal field study (KB0120) of Zimeta for the ... by the Company. --> ...
(Date:2/11/2016)... Feb. 11, 2016 Potrero Medical, Inc., the developer ... announce the appointment of George M. Rapier, III , ... Antonio, TX , WellMed is one of the nation,s ... and HMO members in Texas and ... out of his own internal medicine practice, he has been ...
Breaking Medicine Technology:
(Date:2/12/2016)... ... February 12, 2016 , ... Each year, the American Physical ... in Anaheim, CA at the Anaheim Convention Center. Almost 10,000 physical therapists across the ... products in action, learn more about their chosen field and network with their colleagues. ...
(Date:2/12/2016)... Atlanta, GA (PRWEB) , ... February 12, 2016 ... ... and relationship-marketing firm announced that nominations have closed for the ISE Southeast Awards ... categories will be announced at the ISE® Southeast Executive Forum and Awards Gala ...
(Date:2/12/2016)... , ... February 12, 2016 , ... Every winter, someone ... This winter the West Penn Burn Center, part of the Allegheny Health ... to bring you the “Space Heaters Need Space” campaign. , “Space ...
(Date:2/12/2016)... ... ... The Jones Agency, a family owned insurance company with offices serving Arlington, Dallas, ... with the Tarrant Area Food Bank in the hopes of alleviating hunger for nearby ... Tarrant County Food Bank offers hope and security to the one in six Texas ...
(Date:2/12/2016)... ... February 12, 2016 , ... Young Asset Protection, a full ... of the latest charity campaign in their community enrichment program. Art Expression utilizes ... worthy cause are currently being accepted at: http://artexpressioninc.org/ . , Art Expression ...
Breaking Medicine News(10 mins):